Casp1 (caspase 1) - Rat Genome Database

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Gene: Casp1 (caspase 1) Mus musculus
Analyze
Symbol: Casp1
Name: caspase 1
RGD ID: 731729
MGI Page MGI
Description: Enables cysteine-type endopeptidase activity. Involved in several processes, including positive regulation of interleukin-1 beta production; positive regulation of release of cytochrome c from mitochondria; and protein autoprocessing. Acts upstream of or within several processes, including membrane hyperpolarization; mitochondrial depolarization; and positive regulation of cytokine production. Located in extracellular region. Part of IPAF inflammasome complex. Is expressed in knee joint and metanephros. Orthologous to human CASP1 (caspase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Casp; CASP-1; caspase-1; IC; ICE; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL-1BC; Il1; Il1bc; interleukin 1 beta-converting enzyme; interleukin-1 beta convertase; interleukin-1 beta-converting enzyme; p45
RGD Orthologs
Human
Rat
Bonobo
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3995,298,517 - 5,307,281 (+)NCBIGRCm39mm39
GRCm39 Ensembl95,298,508 - 5,307,290 (+)Ensembl
GRCm3895,298,517 - 5,307,281 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl95,298,508 - 5,307,290 (+)EnsemblGRCm38mm10GRCm38
MGSCv3795,298,517 - 5,307,281 (+)NCBIGRCm37mm9NCBIm37
MGSCv3695,298,517 - 5,307,281 (+)NCBImm8
Celera3117,396,675 - 117,405,459 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (EXP)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (EXP,ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-benzoquinone  (EXP)
1,4-dithiothreitol  (EXP)
1,4-phenylenediamine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (ISO)
2,5-hexanedione  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-mercaptopropanoic acid  (EXP)
3-methyladenine  (EXP,ISO)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (EXP)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (EXP)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
7-ketocholesterol  (EXP)
acetamide  (ISO)
acetic acid  (ISO)
aclacinomycin A  (EXP)
aconitine  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allicin  (EXP)
allopurinol  (ISO)
alpha-pinene  (ISO)
aluminium hydroxide  (EXP,ISO)
aluminium sulfate (anhydrous)  (EXP)
AM-251  (ISO)
amitriptyline  (EXP)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
apocynin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
ATP  (EXP,ISO)
atrazine  (EXP,ISO)
aurantio-obtusin  (EXP)
Belnacasan  (EXP,ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Bergenin  (ISO)
beta-eudesmol  (EXP)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A5  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP,ISO)
CCCP  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chloroethene  (EXP)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
chrysin  (ISO)
cimetidine  (ISO)
cisplatin  (EXP,ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP,ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
dextran sulfate  (EXP,ISO)
diallyl disulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
dibutylstannane  (ISO)
dichloromethane  (EXP)
dichlorvos  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (EXP)
dimethylarsinous acid  (ISO)
dimethyldithiocarbamate  (EXP)
dioxygen  (ISO)
diprotium oxide  (EXP)
dipyridamole  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
emodin  (EXP)
endosulfan  (EXP)
ergosterol  (ISO)
Erionite  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylenediaminetetraacetic acid  (EXP)
fluoxetine  (ISO)
fluvastatin  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
Fraxinellone  (ISO)
fructose  (ISO)
furan  (EXP,ISO)
furosemide  (ISO)
Fusaric acid  (ISO)
galangin  (ISO)
gefitinib  (ISO)
genistein  (ISO)
genkwanin  (ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
glyburide  (EXP,ISO)
glycidol  (ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (EXP,ISO)
homocysteine  (EXP)
HU-308  (EXP)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
ifosfamide  (EXP)
imiquimod  (ISO)
immunological adjuvant  (ISO)
indometacin  (ISO)
irinotecan  (EXP,ISO)
isoprenaline  (ISO)
kaempferol  (ISO)
L-1,4-dithiothreitol  (EXP)
lead diacetate  (EXP)
leflunomide  (ISO)
lenalidomide  (ISO)
leptomycin B  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP)
luteolin  (ISO)
LY294002  (EXP,ISO)
magnesium dihydroxide  (EXP,ISO)
maneb  (EXP)
melatonin  (EXP,ISO)
memantine  (EXP)
mercaptoethanol  (EXP)
mercury atom  (EXP)
mercury dichloride  (EXP)
mercury(0)  (EXP)
metformin  (ISO)
methamphetamine  (EXP)
methyl beta-cyclodextrin  (EXP)
methyl methanesulfonate  (ISO)
microcystin-LR  (EXP)
minocycline  (EXP,ISO)
Mitotane  (ISO)
morphine  (ISO)
mycophenolic acid  (EXP)
mycotoxin  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-ethyl-5'-carboxamidoadenosine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
niclosamide  (EXP,ISO)
nicotine  (ISO)
nigericin  (EXP,ISO)
nimustine  (EXP)
nitrates  (ISO)
nitric oxide  (EXP)
nitroflurbiprofen  (EXP)
nitroglycerin  (ISO)
NMN zwitterion  (EXP,ISO)
Nonidet P-40  (ISO)
ochratoxin A  (EXP)
octanoic acid  (ISO)
oxidopamine  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
Palbinone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phencyclidine  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
phosphoramide mustard  (ISO)
pirinixic acid  (ISO)
Polpunonic acid  (EXP)
potassium atom  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probenecid  (EXP)
procyanidin B2  (ISO)
propylparaben  (ISO)
pterostilbene  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quinolin-8-ol  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
rimonabant  (ISO)
ritonavir  (ISO)
rotenone  (EXP,ISO)
rutin  (ISO)
S-allylcysteine  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
salicylic acid  (ISO)
Salidroside  (EXP,ISO)
sanguinarine  (ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
Sodium salicylate  (ISO)
sorafenib  (ISO)
staurosporine  (ISO)
sterigmatocystin  (EXP)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulfur dioxide  (ISO)
suramin  (ISO)
taurine  (EXP,ISO)
tellurium atom  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP,ISO)
thiram  (EXP)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
toluene 2,4-diisocyanate  (EXP)
Tributyltin oxide  (EXP)
triclosan  (EXP)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
verapamil  (EXP)
vinclozolin  (ISO)
vincristine  (ISO)
water  (EXP)
wortmannin  (EXP)
Y-27632  (ISO)
zearalenone  (EXP,ISO)
zinc atom  (EXP)
zinc oxide  (EXP)
zinc pyrithione  (ISO)
zinc(0)  (EXP)
ziram  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IBA)
apoptotic process  (IBA,ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to organic substance  (ISO)
cellular response to type II interferon  (ISO)
cytokine precursor processing  (ISO)
defense response to Gram-negative bacterium  (IMP)
defense response to virus  (IC)
lung development  (ISO)
membrane hyperpolarization  (IMP)
memory  (ISO)
microglial cell activation  (ISO)
midgut development  (ISO)
mitochondrial depolarization  (IMP)
myoblast fusion  (ISO)
osmosensory signaling pathway  (IC)
pattern recognition receptor signaling pathway  (IC,IDA)
positive regulation of apoptotic process  (ISO)
positive regulation of circadian sleep/wake cycle, non-REM sleep  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of cytokine production  (IDA,ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IDA,ISO)
positive regulation of inflammatory response  (IC,IDA,ISO)
positive regulation of interleukin-1 alpha production  (IMP)
positive regulation of interleukin-1 beta production  (IC,IDA,IMP,ISO)
positive regulation of macrophage cytokine production  (IMP)
positive regulation of neuron apoptotic process  (IDA)
positive regulation of release of cytochrome c from mitochondria  (IDA)
positive regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
programmed necrotic cell death  (IDA)
protein autoprocessing  (IDA,ISO)
protein processing  (IDA,IMP)
proteolysis  (ISO)
pyroptosis  (IC,IDA,IMP,ISO)
regulation of apoptotic process  (IEA)
regulation of autophagy  (IMP)
regulation of inflammatory response  (IBA,IMP,ISO)
response to ATP  (IMP)
response to bacterium  (IMP)
response to hypoxia  (IMP,ISO)
response to lipopolysaccharide  (IDA,ISO)
response to organic cyclic compound  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (ISO)
signaling receptor ligand precursor processing  (ISO)
toxin transport  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal apoptosis  (IAGP)
abnormal cell migration  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal gut flora balance  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal response to infection  (IAGP)
cecum inflammation  (IAGP)
decreased apoptosis  (IAGP)
decreased circulating interferon-gamma level  (IAGP)
decreased circulating interleukin-1 alpha level  (IAGP)
decreased circulating interleukin-1 beta level  (IAGP)
decreased circulating interleukin-18 level  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased circulating tumor necrosis factor level  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased inflammatory response  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-1 alpha secretion  (IAGP)
decreased interleukin-1 beta secretion  (IAGP)
decreased interleukin-18 secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased macrophage apoptosis  (IAGP)
decreased metastatic potential  (IAGP)
decreased neuron apoptosis  (IAGP)
decreased renal glomerular filtration rate  (IAGP)
decreased sensitivity to induced morbidity/mortality  (IAGP)
decreased sensitivity to xenobiotic induced morbidity/mortality  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased susceptibility to ischemic brain injury  (IAGP)
decreased T cell apoptosis  (IAGP)
decreased thymocyte apoptosis  (IAGP)
decreased tumor growth/size  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
growth/size/body region phenotype  (IAGP)
homeostasis/metabolism phenotype  (IAGP)
impaired neutrophil chemotaxis  (IAGP)
increased circulating interleukin-18 level  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to induced colitis  (IAGP)
kidney failure  (IAGP)
renal tubular necrosis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on IL-1 beta, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia. Boost KA, etal., Intensive Care Med. 2007 May;33(5):863-71. Epub 2007 Mar 24.
2. A molecular platform in neurons regulates inflammation after spinal cord injury. de Rivero Vaccari JP, etal., J Neurosci. 2008 Mar 26;28(13):3404-14.
3. [Expression and significance of caspase-1 in benign hyperplastic prostate tissues] Deng CH, etal., Zhonghua Nan Ke Xue. 2005 Nov;11(11):810-2.
4. Immunological and inflammatory functions of the interleukin-1 family. Dinarello CA Annu Rev Immunol. 2009;27:519-50.
5. Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism. Eisenberg SP, etal., Proc Natl Acad Sci U S A 1991 Jun 15;88(12):5232-6.
6. Increased apoptosis of peripheral blood mononuclear cells in patients with perennial allergic asthma/rhinitis: relation to serum markers of apoptosis. Grzegorczyk J, etal., Mediators Inflamm. 2002 Aug;11(4):225-33.
7. Inflammatory markers in nondiabetic and diabetic rat retinas exposed to ischemia followed by reperfusion. Gustavsson C, etal., Retina. 2008 Apr;28(4):645-52.
8. Role of caspases on cell death, inflammation, and cell cycle in glycerol-induced acute renal failure. Homsi E, etal., Kidney Int. 2006 Apr;69(8):1385-92.
9. Role of proinflammatory cytokines IL-18 and IL-1beta in bleomycin-induced lung injury in humans and mice. Hoshino T, etal., Am J Respir Cell Mol Biol. 2009 Dec;41(6):661-70. Epub 2009 Mar 5.
10. Role of epigenetic regulatory mechanisms in neonatal hypoxic-ischemic brain injury. Kumral A, etal., Early Hum Dev. 2013 Mar;89(3):165-73. doi: 10.1016/j.earlhumdev.2012.09.016. Epub 2012 Oct 6.
11. The NALP1 inflammasome controls cytokine production and nociception in a rat fracture model of complex regional pain syndrome. Li WW, etal., Pain. 2009 Dec 15;147(1-3):277-86. Epub 2009 Oct 22.
12. A role for caspase-1 in heart failure. Merkle S, etal., Circ Res. 2007 Mar 16;100(5):645-53. Epub 2007 Feb 15.
13. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
14. MGDs mouse GO annotations MGD data from the GO Consortium
15. MGD IEA MGD IEA
16. Beneficial effects of chelidonic acid on a model of allergic rhinitis. Oh HA, etal., Int Immunopharmacol. 2011 Jan;11(1):39-45. Epub 2010 Oct 23.
17. Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1beta converting enzyme cDNA. Oshikawa K, etal., Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13351-6.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease. Pompl PN, etal., Arch Neurol. 2003 Mar;60(3):369-76.
21. MOLECULAR CLASSIFICATION OF BREAST CARCINOMA IN SITU. Raju U, etal., Curr Genomics. 2006 Dec;7(8):523-532.
22. Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy. Ravizza T, etal., Epilepsia. 2006 Jul;47(7):1160-8.
23. Mouse MP Annotation Import Pipeline RGD automated import pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Lymphocyte apoptosis in acute respiratory syncytial virus bronchiolitis. Roe MF, etal., Clin Exp Immunol. 2004 Jul;137(1):139-45.
26. A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat. Ross J, etal., Neuropharmacology. 2007 Oct;53(5):638-42. Epub 2007 Aug 10.
27. The inflammasomes. Schroder K and Tschopp J, Cell. 2010 Mar 19;140(6):821-32. doi: 10.1016/j.cell.2010.01.040.
28. Activation of caspase-1 dependent interleukins in developmental brain trauma. Sifringer M, etal., Neurobiol Dis. 2007 Mar;25(3):614-22. Epub 2006 Dec 22.
29. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Thomas PG, etal., Immunity. 2009 Apr 17;30(4):566-75. Epub 2009 Apr 9.
30. Up-regulation of microRNA-223 inhibits brain injury and hippocampal neuron apoptosis of rats after febrile seizure through the NLRP3-Caspase-1 signaling pathway. Wang B, etal., Biomed Pharmacother. 2019 Jun;114:108683. doi: 10.1016/j.biopha.2019.108683. Epub 2019 Apr 1.
31. Loss of caspase-1 and caspase-3 protein expression in human prostate cancer. Winter RN, etal., Cancer Res. 2001 Feb 1;61(3):1227-32.
32. Therapeutic effects of caspase-1 inhibitors on acute lung injury in experimental severe acute pancreatitis. Zhang XH, etal., World J Gastroenterol. 2007 Jan 28;13(4):623-7.
Additional References at PubMed
PMID:1431103   PMID:2788176   PMID:7498492   PMID:7535475   PMID:7610484   PMID:7654317   PMID:7798197   PMID:7822802   PMID:7859282   PMID:8034321   PMID:8242740   PMID:8242741  
PMID:8446594   PMID:8565829   PMID:8613694   PMID:8670890   PMID:8905663   PMID:8977187   PMID:8999548   PMID:9015751   PMID:9029121   PMID:9038361   PMID:9047242   PMID:9120399  
PMID:9299161   PMID:9315289   PMID:9317135   PMID:9427519   PMID:9469161   PMID:9490698   PMID:9565639   PMID:9654089   PMID:9723184   PMID:9771644   PMID:9809553   PMID:9837723  
PMID:9878059   PMID:10051653   PMID:10069384   PMID:10087912   PMID:10101687   PMID:10208603   PMID:10222134   PMID:10329594   PMID:10349636   PMID:10353238   PMID:10353249   PMID:10377054  
PMID:10403638   PMID:10452974   PMID:10491411   PMID:10514014   PMID:10532634   PMID:10532635   PMID:10564217   PMID:10618441   PMID:10620118   PMID:10639148   PMID:10671365   PMID:10679104  
PMID:10739653   PMID:10810251   PMID:10869851   PMID:10890909   PMID:10899911   PMID:10899963   PMID:10948135   PMID:11016935   PMID:11042159   PMID:11076861   PMID:11160328   PMID:11217851  
PMID:11238606   PMID:11298831   PMID:11342578   PMID:11376856   PMID:11418486   PMID:11526440   PMID:11536150   PMID:11547333   PMID:11606779   PMID:11684016   PMID:11907086   PMID:12193723  
PMID:12244184   PMID:12393844   PMID:12438367   PMID:12444148   PMID:12466851   PMID:12477932   PMID:12480175   PMID:12650962   PMID:12706898   PMID:12718436   PMID:12788386   PMID:12920043  
PMID:14645573   PMID:14662878   PMID:14663141   PMID:14670305   PMID:14673996   PMID:14693703   PMID:14734619   PMID:15075209   PMID:15128825   PMID:15157512   PMID:15190255   PMID:15489334  
PMID:15507117   PMID:15534227   PMID:15545923   PMID:15569309   PMID:15590467   PMID:15644489   PMID:15695506   PMID:15858021   PMID:15880263   PMID:15963782   PMID:16081822   PMID:16116221  
PMID:16141072   PMID:16141073   PMID:16230474   PMID:16272344   PMID:16301671   PMID:16301672   PMID:16380090   PMID:16407888   PMID:16407889   PMID:16407890   PMID:16429160   PMID:16444259  
PMID:16546100   PMID:16552444   PMID:16565512   PMID:16585594   PMID:16717117   PMID:16861683   PMID:16908867   PMID:16920334   PMID:16974082   PMID:16983331   PMID:16984919   PMID:17004992  
PMID:17008311   PMID:17013693   PMID:17015716   PMID:17087731   PMID:17122101   PMID:17192486   PMID:17255124   PMID:17360653   PMID:17393315   PMID:17403772   PMID:17409187   PMID:17420236  
PMID:17452523   PMID:17491021   PMID:17506816   PMID:17572686   PMID:17599095   PMID:17600714   PMID:17641058   PMID:17878154   PMID:17878377   PMID:17935074   PMID:17959595   PMID:17984289  
PMID:18003616   PMID:18025098   PMID:18070936   PMID:18081695   PMID:18195026   PMID:18227170   PMID:18250441   PMID:18256184   PMID:18268032   PMID:18288107   PMID:18299270   PMID:18322214  
PMID:18322222   PMID:18329368   PMID:18337499   PMID:18374640   PMID:18411310   PMID:18490713   PMID:18490757   PMID:18493980   PMID:18495787   PMID:18496530   PMID:18497737   PMID:18511561  
PMID:18523249   PMID:18566365   PMID:18604209   PMID:18604212   PMID:18667412   PMID:18671821   PMID:18724372   PMID:18725521   PMID:19001420   PMID:19039317   PMID:19050265   PMID:19074813  
PMID:19075245   PMID:19130485   PMID:19131592   PMID:19139171   PMID:19158675   PMID:19158679   PMID:19164858   PMID:19168786   PMID:19179418   PMID:19218193   PMID:19222370   PMID:19237518  
PMID:19339971   PMID:19343209   PMID:19362020   PMID:19465481   PMID:19487481   PMID:19494813   PMID:19521510   PMID:19559631   PMID:19576795   PMID:19587006   PMID:19596996   PMID:19652710  
PMID:19683679   PMID:19696895   PMID:19703976   PMID:19717512   PMID:19734227   PMID:19749746   PMID:19783673   PMID:19801895   PMID:19805629   PMID:19812205   PMID:19918053   PMID:19933859  
PMID:20048047   PMID:20177071   PMID:20194588   PMID:20197547   PMID:20200276   PMID:20226691   PMID:20303296   PMID:20348425   PMID:20351693   PMID:20368281   PMID:20383149   PMID:20385749  
PMID:20428172   PMID:20457908   PMID:20473309   PMID:20495560   PMID:20566831   PMID:20574004   PMID:20585036   PMID:20595632   PMID:20668698   PMID:20671924   PMID:20722078   PMID:20802146  
PMID:20808838   PMID:20814576   PMID:20823203   PMID:20855874   PMID:20876354   PMID:20920345   PMID:20937702   PMID:20940146   PMID:20962258   PMID:20974980   PMID:21037094   PMID:21057511  
PMID:21059925   PMID:21084753   PMID:21106820   PMID:21109192   PMID:21118981   PMID:21147462   PMID:21170027   PMID:21170303   PMID:21178113   PMID:21182088   PMID:21182089   PMID:21248260  
PMID:21267068   PMID:21270263   PMID:21270399   PMID:21282379   PMID:21282498   PMID:21357720   PMID:21396389   PMID:21421853   PMID:21464320   PMID:21471445   PMID:21474346   PMID:21484785  
PMID:21487011   PMID:21533069   PMID:21565393   PMID:21622869   PMID:21666957   PMID:21677131   PMID:21677750   PMID:21681738   PMID:21683629   PMID:21687424   PMID:21708993   PMID:21731762  
PMID:21746921   PMID:21765404   PMID:21771913   PMID:21804020   PMID:21844393   PMID:21856950   PMID:21873635   PMID:21874021   PMID:21876127   PMID:21892172   PMID:21918512   PMID:21930960  
PMID:21940680   PMID:21957143   PMID:22002608   PMID:22046355   PMID:22058415   PMID:22079982   PMID:22101787   PMID:22106299   PMID:22109549   PMID:22143773   PMID:22163019   PMID:22195745  
PMID:22207130   PMID:22213227   PMID:22215738   PMID:22234969   PMID:22235111   PMID:22258606   PMID:22265992   PMID:22286270   PMID:22297845   PMID:22306056   PMID:22308473   PMID:22342844  
PMID:22345669   PMID:22361326   PMID:22365665   PMID:22387558   PMID:22403439   PMID:22411067   PMID:22415881   PMID:22444631   PMID:22461621   PMID:22464733   PMID:22520462   PMID:22541070  
PMID:22555457   PMID:22634614   PMID:22647887   PMID:22658523   PMID:22723524   PMID:22733741   PMID:22753929   PMID:22768222   PMID:22801494   PMID:22802353   PMID:22817986   PMID:22819845  
PMID:22837397   PMID:22840842   PMID:22883230   PMID:22885697   PMID:22902502   PMID:22911706   PMID:22914048   PMID:22940097   PMID:22945633   PMID:22948816   PMID:22980983   PMID:22981536  
PMID:23024281   PMID:23028046   PMID:23035103   PMID:23075849   PMID:23090995   PMID:23115038   PMID:23143333   PMID:23144495   PMID:23148704   PMID:23160218   PMID:23209292   PMID:23209411  
PMID:23219391   PMID:23226472   PMID:23245324   PMID:23254930   PMID:23264657   PMID:23267025   PMID:23297192   PMID:23297415   PMID:23303804   PMID:23307811   PMID:23348507   PMID:23355222  
PMID:23356698   PMID:23371061   PMID:23395675   PMID:23409132   PMID:23427254   PMID:23449592   PMID:23460746   PMID:23487794   PMID:23529619   PMID:23547112   PMID:23589298   PMID:23619996  
PMID:23630357   PMID:23630667   PMID:23644505   PMID:23645208   PMID:23686480   PMID:23716698   PMID:23812099   PMID:23812211   PMID:23887873   PMID:23904166   PMID:23942110   PMID:23942123  
PMID:23964013   PMID:23966627   PMID:23975862   PMID:23977202   PMID:23995233   PMID:24007300   PMID:24022484   PMID:24031018   PMID:24058709   PMID:24078693   PMID:24084736   PMID:24098823  
PMID:24120862   PMID:24123685   PMID:24157462   PMID:24158569   PMID:24185614   PMID:24194505   PMID:24218483   PMID:24312444   PMID:24388751   PMID:24395792   PMID:24395802   PMID:24411736  
PMID:24412611   PMID:24442437   PMID:24449582   PMID:24453255   PMID:24453977   PMID:24481253   PMID:24484406   PMID:24489101   PMID:24492532   PMID:24516390   PMID:24528867   PMID:24581500  
PMID:24595140   PMID:24630989   PMID:24638169   PMID:24696236   PMID:24699513   PMID:24715728   PMID:24739961   PMID:24743949   PMID:24769733   PMID:24789624   PMID:24799700   PMID:24827856  
PMID:24850431   PMID:24875775   PMID:24879791   PMID:24882010   PMID:24919149   PMID:24952429   PMID:24990442   PMID:25017793   PMID:25036629   PMID:25043000   PMID:25075770   PMID:25121752  
PMID:25127135   PMID:25162221   PMID:25166912   PMID:25193701   PMID:25198773   PMID:25225402   PMID:25240383   PMID:25268644   PMID:25274309   PMID:25295542   PMID:25313054   PMID:25367751  
PMID:25372293   PMID:25404286   PMID:25405767   PMID:25405768   PMID:25422455   PMID:25437548   PMID:25452302   PMID:25473914   PMID:25481711   PMID:25501827   PMID:25524927   PMID:25562666  
PMID:25599590   PMID:25605870   PMID:25605939   PMID:25607459   PMID:25628461   PMID:25633245   PMID:25681338   PMID:25684123   PMID:25689249   PMID:25693118   PMID:25704009   PMID:25705884  
PMID:25705917   PMID:25714839   PMID:25715986   PMID:25738962   PMID:25744023   PMID:25774716   PMID:25793272   PMID:25793779   PMID:25795756   PMID:25815426   PMID:25817537   PMID:25848020  
PMID:25855746   PMID:25862090   PMID:25862092   PMID:25879281   PMID:25908663   PMID:25929181   PMID:25959047   PMID:26008898   PMID:26037927   PMID:26038565   PMID:26060214   PMID:26067604  
PMID:26074074   PMID:26091541   PMID:26098997   PMID:26100631   PMID:26119741   PMID:26147228   PMID:26158519   PMID:26173909   PMID:26203636   PMID:26216893   PMID:26232428   PMID:26253163  
PMID:26253422   PMID:26269257   PMID:26320999   PMID:26349656   PMID:26367131   PMID:26375003   PMID:26375259   PMID:26384545   PMID:26405027   PMID:26449474   PMID:26466953   PMID:26516283  
PMID:26536497   PMID:26567013   PMID:26572062   PMID:26572063   PMID:26582949   PMID:26602597   PMID:26611636   PMID:26638072   PMID:26655906   PMID:26676570   PMID:26682985   PMID:26686473  
PMID:26687278   PMID:26689285   PMID:26690700   PMID:26742834   PMID:26810037   PMID:26814970   PMID:26832955   PMID:26877061   PMID:26907476   PMID:26928596   PMID:26968342   PMID:26978520  
PMID:26989816   PMID:26998763   PMID:27006116   PMID:27006445   PMID:27007676   PMID:27015566   PMID:27053298   PMID:27062120   PMID:27071119   PMID:27084336   PMID:27102485   PMID:27103670  
PMID:27108091   PMID:27139490   PMID:27170638   PMID:27251848   PMID:27270401   PMID:27318131   PMID:27339879   PMID:27339979   PMID:27362650   PMID:27365531   PMID:27371534   PMID:27374331  
PMID:27374884   PMID:27402835   PMID:27408775   PMID:27419363   PMID:27450556   PMID:27462105   PMID:27509078   PMID:27524612   PMID:27532042   PMID:27573815   PMID:27589872   PMID:27607578  
PMID:27617861   PMID:27643624   PMID:27692610   PMID:27702746   PMID:27708283   PMID:27732661   PMID:27760760   PMID:27800616   PMID:27803035   PMID:27808091   PMID:27846608   PMID:27869651  
PMID:27882934   PMID:27894300   PMID:27911804   PMID:27912060   PMID:27917412   PMID:27926940   PMID:27939674   PMID:27998728   PMID:28002730   PMID:28032341   PMID:28040362   PMID:28056339  
PMID:28087651   PMID:28087670   PMID:28096356   PMID:28096401   PMID:28126413   PMID:28153878   PMID:28159904   PMID:28249154   PMID:28263976   PMID:28273457   PMID:28314590   PMID:28345580  
PMID:28378742   PMID:28396236   PMID:28404595   PMID:28407357   PMID:28410990   PMID:28410991   PMID:28423682   PMID:28436935   PMID:28442553   PMID:28473584   PMID:28493895   PMID:28537251  
PMID:28614717   PMID:28636595   PMID:28660207   PMID:28662171   PMID:28686578   PMID:28729291   PMID:28739881   PMID:28771586   PMID:28784846   PMID:28790324   PMID:28801921   PMID:28923684  
PMID:28951422   PMID:28961278   PMID:28968459   PMID:28974683   PMID:28990935   PMID:29030458   PMID:29033131   PMID:29045901   PMID:29097366   PMID:29099934   PMID:29100888   PMID:29130929  
PMID:29146733   PMID:29176737   PMID:29196474   PMID:29196621   PMID:29250536   PMID:29255077   PMID:29255148   PMID:29262324   PMID:29274245   PMID:29281832   PMID:29281837   PMID:29358279  
PMID:29396289   PMID:29414788   PMID:29432122   PMID:29458437   PMID:29459437   PMID:29491424   PMID:29500178   PMID:29520027   PMID:29539421   PMID:29558368   PMID:29576451   PMID:29588315  
PMID:29590614   PMID:29653983   PMID:29661823   PMID:29681442   PMID:29695416   PMID:29728534   PMID:29734365   PMID:29735414   PMID:29737568   PMID:29754819   PMID:29774028   PMID:29775594  
PMID:29789522   PMID:29842985   PMID:29866702   PMID:29873075   PMID:29887864   PMID:29891920   PMID:29937272   PMID:29937375   PMID:29957081   PMID:29957172   PMID:29958799   PMID:29972777  
PMID:29996103   PMID:30051912   PMID:30065070   PMID:30089254   PMID:30133699   PMID:30170814   PMID:30254377   PMID:30266768   PMID:30276509   PMID:30388107   PMID:30392787   PMID:30392956  
PMID:30404813   PMID:30409904   PMID:30413620   PMID:30451870   PMID:30485804   PMID:30485805   PMID:30518876   PMID:30571969   PMID:30582442   PMID:30590393   PMID:30596885   PMID:30626747  
PMID:30673616   PMID:30692621   PMID:30718379   PMID:30735126   PMID:30739075   PMID:30748031   PMID:30799265   PMID:30908936   PMID:30930743   PMID:30962463   PMID:30982580   PMID:31015500  
PMID:31029578   PMID:31036765   PMID:31038471   PMID:31063608   PMID:31064994   PMID:31076358   PMID:31085177   PMID:31085641   PMID:31088976   PMID:31108171   PMID:31110285   PMID:31130511  
PMID:31169521   PMID:31251782   PMID:31315440   PMID:31367214   PMID:31379813   PMID:31392775   PMID:31420376   PMID:31430539   PMID:31439870   PMID:31526348   PMID:31533918   PMID:31544965  
PMID:31586037   PMID:31719183   PMID:31723262   PMID:31748744   PMID:31848486   PMID:31923399   PMID:31923400   PMID:31959973   PMID:31967646   PMID:31998283   PMID:32002713   PMID:32032542  
PMID:32041990   PMID:32101731   PMID:32122970   PMID:32129540   PMID:32234476   PMID:32268091   PMID:32282854   PMID:32290861   PMID:32315377   PMID:32345661   PMID:32385413   PMID:32400277  
PMID:32428502   PMID:32515732   PMID:32555186   PMID:32561755   PMID:32595041   PMID:32613271   PMID:32622701   PMID:32641037   PMID:32668247   PMID:32703941   PMID:32726624   PMID:32758418  
PMID:32763970   PMID:32855216   PMID:32989095   PMID:33097533   PMID:33125053   PMID:33135636   PMID:33208362   PMID:33268895   PMID:33278357   PMID:33305736   PMID:33308446   PMID:33398185  
PMID:33414187   PMID:33437899   PMID:33579897   PMID:33623143   PMID:33667383   PMID:33731931   PMID:33761363   PMID:33932961   PMID:33971110   PMID:33976225   PMID:33990906   PMID:33991613  
PMID:34003868   PMID:34038731   PMID:34097907   PMID:34102208   PMID:34188052   PMID:34233954   PMID:34288031   PMID:34315884   PMID:34353890   PMID:34383769   PMID:34437534   PMID:34486483  
PMID:34502478   PMID:34625662   PMID:34648590   PMID:34671981   PMID:34686350   PMID:34715018   PMID:34755743   PMID:34912336   PMID:34929351   PMID:35069570   PMID:35089485   PMID:35143023  
PMID:35281062   PMID:35462787  


Genomics

Comparative Map Data
Casp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3995,298,517 - 5,307,281 (+)NCBIGRCm39mm39
GRCm39 Ensembl95,298,508 - 5,307,290 (+)Ensembl
GRCm3895,298,517 - 5,307,281 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl95,298,508 - 5,307,290 (+)EnsemblGRCm38mm10GRCm38
MGSCv3795,298,517 - 5,307,281 (+)NCBIGRCm37mm9NCBIm37
MGSCv3695,298,517 - 5,307,281 (+)NCBImm8
Celera3117,396,675 - 117,405,459 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
CASP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811105,025,443 - 105,036,686 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11105,025,397 - 105,035,250 (-)EnsemblGRCh38hg38GRCh38
GRCh3711104,896,170 - 104,905,871 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611104,401,445 - 104,411,067 (-)NCBINCBI36hg18NCBI36
Build 3411104,401,448 - 104,411,067NCBI
Celera11102,060,400 - 102,070,022 (-)NCBI
Cytogenetic Map11q22.3NCBI
HuRef11100,827,223 - 100,836,872 (-)NCBIHuRef
CHM1_111104,779,164 - 104,788,813 (-)NCBICHM1_1
T2T-CHM13v2.011105,029,522 - 105,039,223 (-)NCBI
Casp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.282,587,812 - 2,597,403 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl82,587,831 - 2,597,383 (+)Ensembl
Rnor_6.082,605,743 - 2,614,637 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl82,604,962 - 2,614,631 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.082,627,976 - 2,636,870 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.482,027,976 - 2,036,872 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.182,027,975 - 2,036,866 (+)NCBI
Celera82,455,483 - 2,464,376 (+)NCBICelera
Cytogenetic Map8q11NCBI
CASP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111103,448,497 - 103,468,367 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11103,467,368 - 103,468,288 (-)Ensemblpanpan1.1panPan2
PanPan1.1 Ensembl11103,448,497 - 103,458,149 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01199,965,964 - 99,975,640 (-)NCBIMhudiblu_PPA_v0panPan3
CASP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl935,186,420 - 35,200,328 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1935,188,066 - 35,199,364 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2939,210,251 - 39,221,559 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CASP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1196,389,697 - 96,400,610 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl196,389,657 - 96,400,849 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604329,497,194 - 29,506,147 (+)NCBIVero_WHO_p1.0

Position Markers
Casp1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv3795,299,310 - 5,299,865UniSTSGRCm37
Celera3117,404,091 - 117,404,646UniSTS
Cytogenetic Map9A1UniSTS
cM Map91.0UniSTS
cM Map91.0UniSTS
cM Map91.0UniSTS
PMC27008P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3895,303,230 - 5,303,766UniSTSGRCm38
MGSCv3795,303,230 - 5,303,766UniSTSGRCm37
Celera3117,400,190 - 117,400,726UniSTS
Cytogenetic Map9A1UniSTS
cM Map91.0UniSTS
Casp1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3895,299,310 - 5,299,865UniSTSGRCm38
MGSCv3795,299,310 - 5,299,865UniSTSGRCm37
Celera3117,404,091 - 117,404,646UniSTS
Cytogenetic Map9A1UniSTS
Casp1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A1UniSTS
cM Map91.0UniSTS
Casp1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A1UniSTS
cM Map91.0UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142326Tgq19_mtriglyceride QTL 19 (mouse)Not determined121060750Mouse
1300899Chol6_mcholesterol 6 (mouse)Not determined9129902913Mouse
13434920Dcollq1_mdifferential colonization level QTL 1 (mouse)9130341840Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:48
Interacting mature miRNAs:49
Transcripts:ENSMUST00000027015
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000027015   ⟹   ENSMUSP00000027015
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl95,298,508 - 5,307,290 (+)Ensembl
GRCm38.p6 Ensembl95,298,508 - 5,307,290 (+)Ensembl
RefSeq Acc Id: ENSMUST00000238348
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl95,298,686 - 5,307,273 (+)Ensembl
GRCm38.p6 Ensembl95,298,686 - 5,307,273 (+)Ensembl
RefSeq Acc Id: ENSMUST00000238505   ⟹   ENSMUSP00000158737
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl95,298,701 - 5,303,132 (+)Ensembl
GRCm38.p6 Ensembl95,298,701 - 5,303,132 (+)Ensembl
RefSeq Acc Id: ENSMUST00000238546
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl95,298,687 - 5,304,014 (+)Ensembl
GRCm38.p6 Ensembl95,298,687 - 5,304,014 (+)Ensembl
RefSeq Acc Id: ENSMUST00000238730   ⟹   ENSMUSP00000158725
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl95,303,038 - 5,307,203 (+)Ensembl
GRCm38.p6 Ensembl95,303,038 - 5,307,203 (+)Ensembl
RefSeq Acc Id: NM_009807   ⟹   NP_033937
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3995,298,517 - 5,307,281 (+)NCBI
GRCm3895,298,517 - 5,307,281 (+)ENTREZGENE
MGSCv3795,298,517 - 5,307,281 (+)RGD
Celera3117,396,675 - 117,405,459 (-)NCBI
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033937   ⟸   NM_009807
- UniProtKB: P29452 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000027015   ⟸   ENSMUST00000027015
RefSeq Acc Id: ENSMUSP00000158737   ⟸   ENSMUST00000238505
RefSeq Acc Id: ENSMUSP00000158725   ⟸   ENSMUST00000238730
Protein Domains
CARD   CASPASE_P20

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29452-F1-model_v2 AlphaFold P29452 1-402 view protein structure

Promoters
RGD ID:6844283
Promoter ID:MM_KWN:56299
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:NM_009807
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3695,298,386 - 5,298,886 (+)MPROMDB
RGD ID:8668730
Promoter ID:EPDNEW_M12396
Type:multiple initiation site
Name:Casp1_1
Description:Mus musculus caspase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3895,298,687 - 5,298,747EPDNEW
RGD ID:6849287
Promoter ID:MM_XEF:7308
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour
Transcripts:NM_001003125,   NM_001007232,   NM_001009365,   NM_001017534,   NM_001081842,   NM_001223,   NM_012762,   NM_033292,   NM_052889,   NM_214162
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3695,298,826 - 5,299,326 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96544 AgrOrtholog
Ensembl Genes ENSMUSG00000025888 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000027015 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000158725.2 UniProtKB/TrEMBL
  ENSMUSP00000158737.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027015 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000238505.2 UniProtKB/TrEMBL
  ENSMUST00000238730.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caspase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/Swiss-Prot
  Caspase_his_AS UniProtKB/Swiss-Prot
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/Swiss-Prot
  Pept_C14_p20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12362 UniProtKB/Swiss-Prot
MGD MGI:96544 ENTREZGENE
NCBI Gene 12362 ENTREZGENE
PANTHER PTHR10454 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Casp1 PhenoGen
PRINTS IL1BCENZYME UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASPASE_CYS UniProtKB/Swiss-Prot
  CASPASE_HIS UniProtKB/Swiss-Prot
  CASPASE_P10 UniProtKB/Swiss-Prot
  CASPASE_P20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CARD UniProtKB/Swiss-Prot
  CASc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52129 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A571BDI1_MOUSE UniProtKB/TrEMBL
  A0A571BF22_MOUSE UniProtKB/TrEMBL
  CASP1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE