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Gene: Casp1 (caspase 1) Mus musculus
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Symbol: Casp1
Name: caspase 1
Description: Exhibits cysteine-type endopeptidase activity. Involved in several processes, including membrane hyperpolarization; mitochondrial depolarization; and positive regulation of interleukin-1 secretion. Localizes to the IPAF inflammasome complex and extracellular region. Is expressed in knee joint and metanephros. Orthologous to human CASP1 (caspase 1); PARTICIPATES IN interleukin-1 signaling pathway; type II interferon signaling pathway; amyotrophic lateral sclerosis pathway; INTERACTS WITH (+)-dexrazoxane; 1,1-dichloroethene; 1,4-benzoquinone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CASP-1; caspase-1; ICE; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL-1BC; Il1bc; interleukin 1 beta-converting enzyme; interleukin-1 beta convertase; interleukin-1 beta-converting enzyme; p45
Orthologs:
Homo sapiens (human) : CASP1 (caspase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Casp1 (caspase 1)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CASP1 (caspase 1)
Sus scrofa (pig) : CASP1 (caspase 1, apoptosis-related cysteine peptidase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3895,298,517 - 5,307,281 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3795,298,517 - 5,307,281 (+)NCBIGRCm37mm9NCBIm37
MGSCv3695,298,517 - 5,307,281 (+)NCBImm8
Celera3117,396,675 - 117,405,459 (-)NCBICelera
Cytogenetic Map9 A1NCBI
cM Map92.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Casp1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731729
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.