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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp1
Name: caspase 1
Acc ID: CHEBI:46666
Term: crocidolite asbestos
Definition: null
Chemical ID: MESH:D017638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp1increases activityISOCASP1 (Homo sapiens)6480464CTDAsbestos, Crocidolite results in increased activity of CASP1 proteinPMID:23937860 PMID:25351596
Casp1increases cleavageISOCasp1 (Mus musculus)6480464CTDAsbestos, Crocidolite results in increased cleavage of CASP1 proteinPMID:18403674
Casp1increases cleavageISOCASP1 (Homo sapiens)6480464CTDAsbestos, Crocidolite results in increased cleavage of CASP1 proteinPMID:18403674
Casp1increases expressionISOCASP1 (Homo sapiens)6480464CTDAsbestos, Crocidolite results in increased expression of CASP1 mRNA; Asbestos, Crocidolite results in increased expression of CASP1 protein modified formPMID:23937860 PMID:24885895 PMID:25351596
Casp1increases secretionISOCASP1 (Homo sapiens)6480464CTDAsbestos, Crocidolite results in increased secretion of CASP1 protein modified formPMID:24760326
Casp1multiple interactionsISOCasp1 (Mus musculus)6480464CTD[CASP1 protein affects the susceptibility to Asbestos, Crocidolite] which affects the expression of FGF2 protein; [CASP1 protein affects the susceptibility to Asbestos, Crocidolite] which affects the expression of TFPI2 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of CASP1 protein]; CASP1 protein affects the reaction [Asbestos, Crocidolite results in increased expression of IL18 protein]; NLRP3 protein affects the reaction [Asbestos, Crocidolite results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [Asbestos, Crocidolite results in increased cleavage of CASP1 protein]; Silicon Dioxide analog inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of CASP1 protein]PMID:18403674 PMID:28056339
Casp1multiple interactionsISOCASP1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of CASP1 protein modified form]; CASP1 protein affects the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [Asbestos, Crocidolite results in increased cleavage of CASP1 protein]; Y 27632 inhibits the reaction [Asbestos, Crocidolite results in increased secretion of CASP1 protein modified form]PMID:18403674 PMID:24760326 PMID:24885895
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