PYCARD (PYD and CARD domain containing) - Rat Genome Database

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Pathways
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Gene: PYCARD (PYD and CARD domain containing) Sus scrofa
Analyze
Symbol: PYCARD
Name: PYD and CARD domain containing
RGD ID: 14292619
Description: ENCODES a protein that exhibits protease binding (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN defense response to Gram-positive bacterium (ortholog); inflammatory response (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Albuminuria (ortholog); branched-chain keto acid dehydrogenase kinase deficiency (ortholog); FOUND IN AIM2 inflammasome complex (ortholog); canonical inflammasome complex (ortholog); IkappaB kinase complex (ortholog); INTERACTS WITH dextran sulfate; N-acetyl-L-cysteine; ochratoxin A
Type: protein-coding
RefSeq Status: MODEL
Previously known as: apoptosis-associated speck-like protein containing a CARD; ASC; LOC100522011
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,306,099 - 17,307,786 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,305,921 - 17,307,521 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,564,758 - 17,566,360 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (IEA)
cellular response to interleukin-1  (IEA)
cellular response to lipopolysaccharide  (IEA)
cellular response to tumor necrosis factor  (IEA)
defense response to Gram-negative bacterium  (IEA)
defense response to Gram-positive bacterium  (IEA,ISO)
defense response to virus  (IEA)
inflammatory response  (IEA,ISO)
innate immune response  (IEA)
intrinsic apoptotic signaling pathway by p53 class mediator  (IEA)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA)
macropinocytosis  (IEA)
myeloid dendritic cell activation  (IEA)
myeloid dendritic cell activation involved in immune response  (IEA)
negative regulation of canonical NF-kappaB signal transduction  (IEA)
negative regulation of cytokine production involved in inflammatory response  (IEA)
negative regulation of interferon-beta production  (IEA)
NLRP3 inflammasome complex assembly  (IEA)
positive regulation of actin filament polymerization  (IEA)
positive regulation of activated T cell proliferation  (IEA)
positive regulation of adaptive immune response  (IEA)
positive regulation of antigen processing and presentation of peptide antigen via MHC class II  (IEA)
positive regulation of apoptotic process  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of chemokine production  (IEA)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of defense response to virus by host  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of extrinsic apoptotic signaling pathway  (IEA)
positive regulation of inflammatory response  (IEA)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of interleukin-10 production  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of interleukin-8 production  (IEA)
positive regulation of JNK cascade  (IEA)
positive regulation of macrophage cytokine production  (IEA,ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA)
positive regulation of phagocytosis  (IEA)
positive regulation of release of cytochrome c from mitochondria  (IEA)
positive regulation of T cell activation  (IEA)
positive regulation of T cell migration  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of type II interferon production  (IEA)
protein homooligomerization  (IEA)
regulation of apoptotic process  (IEA,ISO)
regulation of autophagy  (IEA,ISO)
regulation of inflammatory response  (IEA,ISO)
regulation of intrinsic apoptotic signaling pathway  (IEA)
regulation of protein stability  (IEA)
regulation of tumor necrosis factor-mediated signaling pathway  (IEA)
response to bacterium  (IEA,ISO)
tumor necrosis factor-mediated signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:27236661  


Genomics

Comparative Map Data
PYCARD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,306,099 - 17,307,786 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,305,921 - 17,307,521 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,564,758 - 17,566,360 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PYCARD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,201,486 - 31,202,760 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,201,486 - 31,203,450 (-)EnsemblGRCh38hg38GRCh38
GRCh371631,212,807 - 31,214,081 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,120,308 - 31,121,752 (-)NCBINCBI36Build 36hg18NCBI36
Celera1629,083,777 - 29,085,221 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,774,423 - 28,775,713 (-)NCBIHuRef
CHM1_11632,530,520 - 32,531,810 (-)NCBICHM1_1
T2T-CHM13v2.01631,588,907 - 31,590,181 (-)NCBIT2T-CHM13v2.0
Pycard
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,590,545 - 127,593,039 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,588,880 - 127,593,039 (-)EnsemblGRCm39 Ensembl
GRCm387127,991,373 - 127,993,867 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,989,708 - 127,993,867 (-)EnsemblGRCm38mm10GRCm38
MGSCv377135,134,887 - 135,137,381 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,783,251 - 127,784,895 (-)NCBIMGSCv36mm8
Celera7127,826,342 - 127,828,839 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.88NCBI
Pycard
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,032,124 - 192,033,419 (-)NCBIGRCr8
mRatBN7.21182,601,657 - 182,603,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,601,174 - 182,602,955 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,952,277 - 190,953,310 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,138,364 - 198,139,397 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,808,830 - 190,809,863 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,438,029 - 199,439,062 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,437,832 - 199,439,210 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,460,883 - 206,461,916 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,276,089 - 187,277,122 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,425,969 - 187,427,003 (-)NCBI
Celera1180,252,771 - 180,253,804 (-)NCBICelera
Cytogenetic Map1q37NCBI
PYCARD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,409,182 - 34,410,910 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,210,581 - 39,211,917 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,764,386 - 23,765,732 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,572,332 - 31,573,828 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,571,363 - 31,573,828 (-)Ensemblpanpan1.1panPan2
PYCARD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,049,352 - 17,051,348 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,049,705 - 17,051,240 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,624,878 - 18,626,631 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,180,447 - 17,182,202 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,180,546 - 17,182,254 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,980,664 - 16,982,415 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,899,792 - 16,901,536 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,211,709 - 17,213,472 (+)NCBIUU_Cfam_GSD_1.0
Pycard
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,452,827 - 125,454,078 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650113,550,679 - 13,552,805 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650113,550,702 - 13,552,774 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PYCARD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,892,332 - 27,894,386 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,889,230 - 27,893,697 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660681,569,924 - 1,571,817 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pycard
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,247,864 - 14,249,000 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478214,247,333 - 14,249,861 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PYCARD
30 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2
Low 8 3 3 5 2 23 1 3 3
Below cutoff 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000054028   ⟹   ENSSSCP00000048640
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl317,306,179 - 17,307,512 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000103784   ⟹   ENSSSCP00000074832
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl317,306,099 - 17,307,786 (+)Ensembl
RefSeq Acc Id: XM_003124468   ⟹   XP_003124516
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1317,305,921 - 17,307,521 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003124516   ⟸   XM_003124468
- UniProtKB: K7GQI7 (UniProtKB/TrEMBL),   A0A0B8RTB5 (UniProtKB/TrEMBL),   A0A4X1TCM8 (UniProtKB/TrEMBL),   A0A8D0J464 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000048640   ⟸   ENSSSCT00000054028
RefSeq Acc Id: ENSSSCP00000074832   ⟸   ENSSSCT00000103784
Protein Domains
CARD   Pyrin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000040811 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005018824 UniProtKB/TrEMBL
  ENSSSCG00015016703 UniProtKB/TrEMBL
  ENSSSCG00025044442 UniProtKB/TrEMBL
  ENSSSCG00030065138 UniProtKB/TrEMBL
  ENSSSCG00035080142 UniProtKB/TrEMBL
  ENSSSCG00040041837 UniProtKB/TrEMBL
  ENSSSCG00045037020 UniProtKB/TrEMBL
  ENSSSCG00055029449 UniProtKB/TrEMBL
  ENSSSCG00060023897 UniProtKB/TrEMBL
  ENSSSCG00065078543 UniProtKB/TrEMBL
  ENSSSCG00070008756 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000054028 ENTREZGENE
  ENSSSCT00000054028.2 UniProtKB/TrEMBL
  ENSSSCT00000103784.1 UniProtKB/TrEMBL
  ENSSSCT00005029678.1 UniProtKB/TrEMBL
  ENSSSCT00015022104.1 UniProtKB/TrEMBL
  ENSSSCT00025060321.1 UniProtKB/TrEMBL
  ENSSSCT00030091006.1 UniProtKB/TrEMBL
  ENSSSCT00035109711.1 UniProtKB/TrEMBL
  ENSSSCT00040056037.1 UniProtKB/TrEMBL
  ENSSSCT00045063818.1 UniProtKB/TrEMBL
  ENSSSCT00055058469.1 UniProtKB/TrEMBL
  ENSSSCT00060032429.1 UniProtKB/TrEMBL
  ENSSSCT00065108925.1 UniProtKB/TrEMBL
  ENSSSCT00070016969.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  CARD8/ASC/NALP1_CARD UniProtKB/TrEMBL
  DAPIN UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:100522011 UniProtKB/TrEMBL
NCBI Gene LOC100522011 ENTREZGENE
PANTHER APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD UniProtKB/TrEMBL
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
  PYRIN UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
  DAPIN UniProtKB/TrEMBL
SMART PYRIN UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
UniProt A0A0B8RTB5 ENTREZGENE
  A0A4X1TCM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0J464 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4F6Q5_PIG UniProtKB/TrEMBL
  K7GQI7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:110705 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-12-12 PYCARD  PYD and CARD domain containing  LOC100522011  apoptosis-associated speck-like protein containing a CARD  Symbol and/or name change 19259463 PROVISIONAL