Nlrp1a (NLR family, pyrin domain containing 1A) - Rat Genome Database

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Gene: Nlrp1a (NLR family, pyrin domain containing 1A) Rattus norvegicus
Analyze
Symbol: Nlrp1a
Name: NLR family, pyrin domain containing 1A
RGD ID: 1310963
Description: Enables scaffold protein binding activity. Involved in negative regulation of cellular defense response and positive regulation of pyroptotic inflammatory response. Located in neuronal cell body. Part of protein-containing complex. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1); PARTICIPATES IN interleukin-1 signaling pathway; NOD-like receptor signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC360557; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD domains-containing protein 1; NACHT, LRR and PYD domains-containing protein 1 allele 2; NACHT, LRR and PYD domains-containing protein 1a; NACHT, LRR and PYD domains-containing protein 1a allele 1; NACHT, LRR and PYD domains-containing protein 1a allele 3; NACHT, LRR and PYD domains-containing protein 1a allele 4; NACHT, LRR and PYD domains-containing protein 1a allele 5; Nalp1; NLR family protein 1; NLR family, pyrin domain containing 1; Nlrp1; resistant anthrax lethal toxin
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81056,277,134 - 56,332,229 (-)NCBIGRCr8
mRatBN7.21055,778,560 - 55,833,639 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,778,560 - 55,825,180 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1060,458,304 - 60,504,924 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,946,824 - 59,993,447 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01055,445,908 - 55,492,512 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,692,474 - 57,747,608 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,692,474 - 57,822,498 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01057,437,815 - 57,492,207 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,963,708 - 58,007,925 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11057,960,835 - 58,122,088 (-)NCBI
Celera1054,924,259 - 54,970,955 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii. Cirelli KM, etal., PLoS Pathog. 2014 Mar 13;10(3):e1003927. doi: 10.1371/journal.ppat.1003927. eCollection 2014 Mar.
2. Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury. de Rivero Vaccari JP, etal., J Cereb Blood Flow Metab. 2009 Jul;29(7):1251-61. Epub 2009 Apr 29.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. The inflammasomes. Schroder K and Tschopp J, Cell. 2010 Mar 19;140(6):821-32. doi: 10.1016/j.cell.2010.01.040.
9. The pannexin 1 channel activates the inflammasome in neurons and astrocytes. Silverman WR, etal., J Biol Chem. 2009 Jul 3;284(27):18143-51. Epub 2009 May 5.
Additional References at PubMed
PMID:11076957   PMID:12191486   PMID:15212762   PMID:16429160   PMID:16575408   PMID:17164409   PMID:18068672   PMID:18511561   PMID:20502689   PMID:22133203   PMID:22479187   PMID:24014157  
PMID:24076348   PMID:24699513   PMID:25024200   PMID:27662089   PMID:30120609   PMID:33731929   PMID:35951283   PMID:38976128  


Genomics

Comparative Map Data
Nlrp1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81056,277,134 - 56,332,229 (-)NCBIGRCr8
mRatBN7.21055,778,560 - 55,833,639 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,778,560 - 55,825,180 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1060,458,304 - 60,504,924 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,946,824 - 59,993,447 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01055,445,908 - 55,492,512 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,692,474 - 57,747,608 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,692,474 - 57,822,498 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01057,437,815 - 57,492,207 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,963,708 - 58,007,925 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11057,960,835 - 58,122,088 (-)NCBI
Celera1054,924,259 - 54,970,955 (-)NCBICelera
Cytogenetic Map10q24NCBI
NLRP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38175,501,396 - 5,584,509 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl175,499,415 - 5,619,424 (-)EnsemblGRCh38hg38GRCh38
GRCh37175,404,716 - 5,487,829 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36175,345,443 - 5,428,556 (-)NCBINCBI36Build 36hg18NCBI36
Celera175,421,095 - 5,503,841 (-)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef175,294,862 - 5,377,604 (-)NCBIHuRef
CHM1_1175,414,362 - 5,497,490 (-)NCBICHM1_1
T2T-CHM13v2.0175,395,133 - 5,478,273 (-)NCBIT2T-CHM13v2.0
Nlrp1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,982,023 - 71,035,780 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,983,062 - 71,035,530 (-)EnsemblGRCm39 Ensembl
GRCm381171,091,197 - 71,144,969 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,092,236 - 71,144,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv371170,904,699 - 70,958,206 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,908,431 - 70,958,561 (-)NCBIMGSCv36mm8
Celera1178,634,796 - 78,688,328 (-)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1143.21NCBI
NLRP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21913,096,919 - 13,194,847 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11715,079,526 - 15,162,296 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0175,562,129 - 5,667,765 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1175,541,559 - 5,623,659 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl175,542,007 - 5,623,091 (-)Ensemblpanpan1.1panPan2
NLRP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,264,554 - 31,299,538 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,266,621 - 31,299,304 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha531,399,983 - 31,440,503 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0531,369,269 - 31,407,109 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl531,370,391 - 31,404,052 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1531,334,819 - 31,372,650 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0531,293,857 - 31,331,580 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0531,467,813 - 31,507,973 (+)NCBIUU_Cfam_GSD_1.0
Nlrp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560253,611,186 - 53,653,113 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366772,248,903 - 2,289,151 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366772,248,153 - 2,290,802 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLRP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11251,479,968 - 51,495,540 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NLRP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,930,643 - 4,983,378 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605916,600,759 - 16,674,092 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:78
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000037546
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105269900459876693Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105429622758944345Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001145755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ665183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM060628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM060629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM060630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM060631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM060632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM060633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM060634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM060635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM060636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM060637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM060638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM060639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000037546   ⟹   ENSRNOP00000034130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1055,781,885 - 55,825,138 (-)Ensembl
Rnor_6.0 Ensembl1057,695,802 - 57,822,498 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082171   ⟹   ENSRNOP00000073609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1055,778,560 - 55,825,180 (-)Ensembl
Rnor_6.0 Ensembl1057,692,474 - 57,739,109 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093906   ⟹   ENSRNOP00000089800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1055,781,885 - 55,825,180 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094927   ⟹   ENSRNOP00000091173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1055,778,560 - 55,825,138 (-)Ensembl
RefSeq Acc Id: NM_001145755   ⟹   NP_001139227
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81056,277,134 - 56,323,756 (-)NCBI
mRatBN7.21055,778,560 - 55,825,180 (-)NCBI
Rnor_6.01057,692,474 - 57,739,109 (-)NCBI
Rnor_5.01057,437,815 - 57,492,207 (-)NCBI
RGSC_v3.41057,963,708 - 58,007,925 (-)RGD
Celera1054,924,259 - 54,970,955 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246755   ⟹   XP_006246817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81056,277,134 - 56,332,229 (-)NCBI
mRatBN7.21055,778,560 - 55,833,639 (-)NCBI
Rnor_6.01057,692,474 - 57,747,608 (-)NCBI
Rnor_5.01057,437,815 - 57,492,207 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086323   ⟹   XP_038942251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81056,277,134 - 56,332,229 (-)NCBI
mRatBN7.21055,781,483 - 55,833,639 (-)NCBI
RefSeq Acc Id: XM_039086324   ⟹   XP_038942252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81056,277,134 - 56,332,202 (-)NCBI
mRatBN7.21055,781,483 - 55,824,986 (-)NCBI
RefSeq Acc Id: XM_039086325   ⟹   XP_038942253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81056,306,215 - 56,332,225 (-)NCBI
mRatBN7.21055,807,638 - 55,833,639 (-)NCBI
RefSeq Acc Id: XR_005489886
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81056,281,155 - 56,332,225 (-)NCBI
mRatBN7.21055,782,581 - 55,833,639 (-)NCBI
RefSeq Acc Id: NP_001139227   ⟸   NM_001145755
- UniProtKB: D9I2G3 (UniProtKB/Swiss-Prot),   A0A0G2QC28 (UniProtKB/Swiss-Prot),   F1LPA5 (UniProtKB/Swiss-Prot),   D9I2F9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246817   ⟸   XM_006246755
- Peptide Label: isoform X1
- UniProtKB: D9I2G3 (UniProtKB/Swiss-Prot),   A0A0G2QC28 (UniProtKB/Swiss-Prot),   F1LPA5 (UniProtKB/Swiss-Prot),   D9I2F9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073609   ⟸   ENSRNOT00000082171
Ensembl Acc Id: ENSRNOP00000034130   ⟸   ENSRNOT00000037546
RefSeq Acc Id: XP_038942251   ⟸   XM_039086323
- Peptide Label: isoform X2
- UniProtKB: D9I2H0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038942252   ⟸   XM_039086324
- Peptide Label: isoform X3
- UniProtKB: D9I2G3 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038942253   ⟸   XM_039086325
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000091173   ⟸   ENSRNOT00000094927
Ensembl Acc Id: ENSRNOP00000089800   ⟸   ENSRNOT00000093906
Protein Domains
CARD   FIIND   NACHT

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310963 AgrOrtholog
BioCyc Gene G2FUF-24410 BioCyc
Ensembl Genes ENSRNOG00000023143 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037546.7 UniProtKB/TrEMBL
  ENSRNOT00000082171.2 UniProtKB/TrEMBL
  ENSRNOT00000093906.1 UniProtKB/TrEMBL
  ENSRNOT00000094927.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARD8/ASC/NALP1_CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FIIND_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NLRP_HD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NLRP_Inflammasome UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOD2_WH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:360557 UniProtKB/Swiss-Prot
NCBI Gene 360557 ENTREZGENE
PANTHER NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 UniProtKB/Swiss-Prot
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 UniProtKB/Swiss-Prot
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
Pfam CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FIIND UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NLRC4_HD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOD2_WH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nlrp1a PhenoGen
PRINTS DISEASERSIST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FIIND UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023143 RatGTEx
SMART LRR_RI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RNI-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2QC28 ENTREZGENE
  A0A805TYK3_RAT UniProtKB/TrEMBL
  A0A8I6ACH1_RAT UniProtKB/TrEMBL
  A0A8I6AFM6_RAT UniProtKB/TrEMBL
  A0A8L2R8A1_RAT UniProtKB/TrEMBL
  D9I2F9 ENTREZGENE
  D9I2G1 ENTREZGENE
  D9I2G3 ENTREZGENE
  D9I2G4 ENTREZGENE
  D9I2H0 ENTREZGENE
  F1LPA5 ENTREZGENE
  NL1A1_RAT UniProtKB/Swiss-Prot
  NL1A2_RAT UniProtKB/Swiss-Prot
  NL1A3_RAT UniProtKB/Swiss-Prot
  NL1A4_RAT UniProtKB/Swiss-Prot
  NL1A5_RAT UniProtKB/Swiss-Prot
UniProt Secondary A0A0G2QC28 UniProtKB/Swiss-Prot
  F1LPA5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-02-18 Nlrp1a  NLR family, pyrin domain containing 1A  Nlrp1  NLR family, pyrin domain containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-15 Nlrp1  NLR family, pyrin domain containing 1  LOC687766  similar to NACHT, leucine rich repeat and PYD containing 1  Data merged from RGD:1597519 1643240 APPROVED
2009-06-15 Nlrp1  NLR family, pyrin domain containing 1  LOC687763  similar to NACHT, leucine rich repeat and PYD containing 1  Data merged from RGD:1597522 1643240 APPROVED
2008-09-26 Nlrp1  NLR family, pyrin domain containing 1  Nlrp1a  NLR family, pyrin domain containing 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Nlrp1a  NLR family, pyrin domain containing 1A  Nalp1_predicted  NACHT, leucine rich repeat and PYD containing 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC687763  similar to NACHT, leucine rich repeat and PYD containing 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC687766  similar to NACHT, leucine rich repeat and PYD containing 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Nalp1_predicted  NACHT, leucine rich repeat and PYD containing 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED