Symbol:
Nlrp1a
Name:
NLR family, pyrin domain containing 1A
RGD ID:
1310963
Description:
Enables scaffold protein binding activity. Involved in negative regulation of cellular defense response and positive regulation of pyroptotic inflammatory response. Located in neuronal cell body. Part of protein-containing complex. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1); PARTICIPATES IN interleukin-1 signaling pathway; NOD-like receptor signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC360557; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD domains-containing protein 1; NACHT, LRR and PYD domains-containing protein 1 allele 2; NACHT, LRR and PYD domains-containing protein 1a; NACHT, LRR and PYD domains-containing protein 1a allele 1; NACHT, LRR and PYD domains-containing protein 1a allele 3; NACHT, LRR and PYD domains-containing protein 1a allele 4; NACHT, LRR and PYD domains-containing protein 1a allele 5; Nalp1; NLR family protein 1; NLR family, pyrin domain containing 1; Nlrp1; resistant anthrax lethal toxin
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 10 56,277,134 - 56,332,229 (-) NCBI GRCr8 mRatBN7.2 10 55,778,560 - 55,833,639 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 10 55,778,560 - 55,825,180 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 10 60,458,304 - 60,504,924 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 10 59,946,824 - 59,993,447 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 10 55,445,908 - 55,492,512 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 10 57,692,474 - 57,747,608 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 10 57,692,474 - 57,822,498 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 10 57,437,815 - 57,492,207 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 10 57,963,708 - 58,007,925 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 10 57,960,835 - 58,122,088 (-) NCBI Celera 10 54,924,259 - 54,970,955 (-) NCBI Celera Cytogenetic Map 10 q24 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Only show annotations with direct experimental evidence (0 objects hidden)
Nlrp1a Rat 1,2-dichloroethane increases expression ISO RGD:1623841 6480464 ethylene dichloride results in increased expression of NLRP1A mRNA CTD PMID:28960355 Nlrp1a Rat 17beta-estradiol multiple interactions ISO RGD:1322162 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of NLRP1 mRNA CTD PMID:30165855 Nlrp1a Rat 17beta-estradiol multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of NLRP1A mRNA CTD PMID:32741896 Nlrp1a Rat 17beta-estradiol 3-benzoate multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of NLRP1A mRNA CTD PMID:32741896 Nlrp1a Rat 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) multiple interactions ISO RGD:1322162 6480464 [CYP3A4 protein affects the susceptibility to 2,2'-methylenebis(4-methyl-6-tert-butylphenol)] which affects the expression of NLRP1 mRNA CTD PMID:38160208 Nlrp1a Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1623841 6480464 Tetrachlorodibenzodioxin affects the expression of NLRP1A mRNA CTD PMID:21570461 Nlrp1a Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of NLRP1A mRNA CTD PMID:33387578 Nlrp1a Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of NLRP1A mRNA CTD PMID:34747641 Nlrp1a Rat 4,4'-sulfonyldiphenol decreases methylation ISO RGD:1322162 6480464 bisphenol S results in decreased methylation of NLRP1 gene CTD PMID:31601247 Nlrp1a Rat 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ... CTD PMID:36041667 Nlrp1a Rat acetamide increases expression EXP 6480464 acetamide results in increased expression of NLRP1A mRNA CTD PMID:31881176 Nlrp1a Rat acrolein multiple interactions ISO RGD:1322162 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of more ... CTD PMID:32699268 Nlrp1a Rat acrylamide decreases expression ISO RGD:1322162 6480464 Acrylamide results in decreased expression of NLRP1 mRNA CTD PMID:32763439 Nlrp1a Rat actinomycin D multiple interactions ISO RGD:1322162 6480464 [Dactinomycin co-treated with nutlin 3] results in increased expression of NLRP1 mRNA CTD PMID:38460933 Nlrp1a Rat Aflatoxin B2 alpha increases methylation ISO RGD:1322162 6480464 aflatoxin B2 results in increased methylation of NLRP1 intron CTD PMID:30157460 Nlrp1a Rat alpha-pinene multiple interactions ISO RGD:1322162 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of more ... CTD PMID:32699268 Nlrp1a Rat aristolochic acid A increases expression ISO RGD:1322162 6480464 aristolochic acid I results in increased expression of NLRP1 mRNA CTD PMID:33212167 Nlrp1a Rat arsane multiple interactions ISO RGD:1322162 6480464 [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NLRP1 more ... CTD PMID:39836092 Nlrp1a Rat arsenic atom multiple interactions ISO RGD:1322162 6480464 [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NLRP1 more ... CTD PMID:39836092 Nlrp1a Rat arsenite(3-) affects expression ISO RGD:1322162 6480464 arsenite affects the expression of NLRP1 mRNA CTD PMID:22959463 Nlrp1a Rat arsenous acid multiple interactions ISO RGD:1322162 6480464 [sanguinarine co-treated with Arsenic Trioxide] results in increased expression of NLRP1 mRNA CTD PMID:24345465 Nlrp1a Rat arsenous acid increases expression ISO RGD:1322162 6480464 Arsenic Trioxide results in increased expression of NLRP1 mRNA CTD PMID:24345465 Nlrp1a Rat ATP multiple interactions ISO RGD:1322162 6480464 [Lipopolysaccharides co-treated with Adenosine Triphosphate co-treated with resveratrol] results in increased expression of NLRP1 mRNA CTD PMID:24149798 Nlrp1a Rat Azoxymethane multiple interactions ISO RGD:1623841 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of NLRP1A more ... CTD PMID:29950665 Nlrp1a Rat beauvericin increases expression ISO RGD:1322162 6480464 beauvericin results in increased expression of NLRP1 mRNA CTD PMID:29203277 Nlrp1a Rat benzo[a]pyrene affects methylation ISO RGD:1322162 6480464 Benzo(a)pyrene affects the methylation of NLRP1 intron; Benzo(a)pyrene affects the methylation of NLRP1 promoter CTD PMID:27901495|PMID:30157460 Nlrp1a Rat benzo[a]pyrene increases expression ISO RGD:1322162 6480464 Benzo(a)pyrene results in increased expression of NLRP1 mRNA CTD PMID:32234424 Nlrp1a Rat benzo[a]pyrene diol epoxide I increases expression ISO RGD:1322162 6480464 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NLRP1 mRNA CTD PMID:20382639 Nlrp1a Rat benzo[e]pyrene increases methylation ISO RGD:1322162 6480464 benzo(e)pyrene results in increased methylation of NLRP1 intron CTD PMID:30157460 Nlrp1a Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of NLRP1 mRNA; bisphenol A results in decreased expression more ... CTD PMID:25181051|PMID:30816183|PMID:34947998 Nlrp1a Rat bisphenol A increases expression ISO RGD:1623841 6480464 bisphenol A results in increased expression of NLRP1A mRNA CTD PMID:32156529 Nlrp1a Rat bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ... CTD PMID:36041667 Nlrp1a Rat bisphenol A decreases methylation ISO RGD:1322162 6480464 bisphenol A results in decreased methylation of NLRP1 gene CTD PMID:31601247 Nlrp1a Rat bisphenol F multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ... CTD PMID:36041667 Nlrp1a Rat calcitriol increases expression ISO RGD:1322162 6480464 Calcitriol results in increased expression of NLRP1 mRNA CTD PMID:16002434 Nlrp1a Rat cantharidin increases expression ISO RGD:1623841 6480464 Cantharidin results in increased expression of NLRP1A mRNA CTD PMID:36907384 Nlrp1a Rat carbon nanotube decreases expression ISO RGD:1623841 6480464 Nanotubes, Carbon results in decreased expression of NLRP1A mRNA CTD PMID:25554681 Nlrp1a Rat CGP 52608 multiple interactions ISO RGD:1322162 6480464 CGP 52608 promotes the reaction [RORA protein binds to NLRP1 gene] CTD PMID:28238834 Nlrp1a Rat cisplatin multiple interactions ISO RGD:1322162 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of NLRP1 mRNA; [Cisplatin co-treated with Panobinostat] more ... CTD PMID:21791302|PMID:27392435 Nlrp1a Rat cisplatin increases expression ISO RGD:1322162 6480464 Cisplatin results in increased expression of NLRP1 mRNA CTD PMID:27392435 Nlrp1a Rat cobalt dichloride decreases expression ISO RGD:1322162 6480464 cobaltous chloride results in decreased expression of NLRP1 mRNA CTD PMID:19320972 Nlrp1a Rat copper atom multiple interactions ISO RGD:1322162 6480464 [NSC 689534 binds to Copper] which results in increased expression of NLRP1 mRNA CTD PMID:20971185 Nlrp1a Rat copper(0) multiple interactions ISO RGD:1322162 6480464 [NSC 689534 binds to Copper] which results in increased expression of NLRP1 mRNA CTD PMID:20971185 Nlrp1a Rat copper(II) sulfate decreases expression ISO RGD:1322162 6480464 Copper Sulfate results in decreased expression of NLRP1 mRNA CTD PMID:19549813 Nlrp1a Rat dextran sulfate multiple interactions ISO RGD:1623841 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of NLRP1A more ... CTD PMID:29950665 Nlrp1a Rat diarsenic trioxide multiple interactions ISO RGD:1322162 6480464 [sanguinarine co-treated with Arsenic Trioxide] results in increased expression of NLRP1 mRNA CTD PMID:24345465 Nlrp1a Rat diarsenic trioxide increases expression ISO RGD:1322162 6480464 Arsenic Trioxide results in increased expression of NLRP1 mRNA CTD PMID:24345465 Nlrp1a Rat diazinon affects expression EXP 6480464 Diazinon affects the expression of NLRP1A mRNA CTD PMID:22546817 Nlrp1a Rat Dibutyl phosphate affects expression ISO RGD:1322162 6480464 di-n-butylphosphoric acid affects the expression of NLRP1 mRNA CTD PMID:37042841 Nlrp1a Rat diclofenac multiple interactions EXP 6480464 Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of NLRP1A protein] CTD PMID:25450234 Nlrp1a Rat dicrotophos increases expression ISO RGD:1322162 6480464 dicrotophos results in increased expression of NLRP1 mRNA CTD PMID:28302478 Nlrp1a Rat doxorubicin increases expression ISO RGD:1322162 6480464 Doxorubicin results in increased expression of NLRP1 mRNA CTD PMID:29803840 Nlrp1a Rat gallic acid increases expression ISO RGD:1322162 6480464 Gallic Acid results in increased expression of NLRP1 mRNA CTD PMID:34408198 Nlrp1a Rat gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of NLRP1A mRNA CTD PMID:33387578 Nlrp1a Rat lipopolysaccharide multiple interactions ISO RGD:1322162 6480464 [Lipopolysaccharides co-treated with Adenosine Triphosphate co-treated with resveratrol] results in increased expression of NLRP1 mRNA CTD PMID:24149798 Nlrp1a Rat lipopolysaccharide increases expression ISO RGD:1623841 6480464 Lipopolysaccharides results in increased expression of NLRP1A mRNA CTD PMID:22147977 Nlrp1a Rat luteolin multiple interactions EXP 6480464 Luteolin inhibits the reaction [Freund's Adjuvant results in increased expression of NLRP1A protein] CTD PMID:25450234 Nlrp1a Rat mercury atom decreases expression ISO RGD:1322162 6480464 Mercury results in decreased expression of NLRP1 mRNA CTD PMID:19937285 Nlrp1a Rat mercury(0) decreases expression ISO RGD:1322162 6480464 Mercury results in decreased expression of NLRP1 mRNA CTD PMID:19937285 Nlrp1a Rat methapyrilene increases methylation ISO RGD:1322162 6480464 Methapyrilene results in increased methylation of NLRP1 intron CTD PMID:30157460 Nlrp1a Rat Nutlin-3 multiple interactions ISO RGD:1322162 6480464 [Dactinomycin co-treated with nutlin 3] results in increased expression of NLRP1 mRNA CTD PMID:38460933 Nlrp1a Rat okadaic acid decreases expression ISO RGD:1322162 6480464 Okadaic Acid results in decreased expression of NLRP1 mRNA CTD PMID:38832940 Nlrp1a Rat ozone multiple interactions ISO RGD:1322162 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of more ... CTD PMID:32699268|PMID:35430440 Nlrp1a Rat p-menthan-3-ol increases expression ISO RGD:1322162 6480464 Menthol results in increased expression of NLRP1 mRNA CTD PMID:26760959 Nlrp1a Rat panobinostat multiple interactions ISO RGD:1322162 6480464 [Cisplatin co-treated with panobinostat] affects the expression of NLRP1 mRNA CTD PMID:21791302 Nlrp1a Rat paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of NLRP1A mRNA CTD PMID:33387578 Nlrp1a Rat pinostrobin increases expression ISO RGD:1322162 6480464 pinostrobin results in increased expression of NLRP1 mRNA CTD PMID:37777166 Nlrp1a Rat resveratrol multiple interactions ISO RGD:1322162 6480464 [Lipopolysaccharides co-treated with Adenosine Triphosphate co-treated with resveratrol] results in increased expression of NLRP1 mRNA CTD PMID:24149798 Nlrp1a Rat resveratrol increases expression ISO RGD:1322162 6480464 resveratrol results in increased expression of NLRP1 mRNA CTD PMID:25436977 Nlrp1a Rat sanguinarine multiple interactions ISO RGD:1322162 6480464 [sanguinarine co-treated with arsenic trioxide] results in increased expression of NLRP1 mRNA CTD PMID:24345465 Nlrp1a Rat sanguinarine increases expression ISO RGD:1322162 6480464 sanguinarine results in increased expression of NLRP1 mRNA CTD PMID:24345465 Nlrp1a Rat silver atom increases expression ISO RGD:1623841 6480464 Silver results in increased expression of NLRP1A mRNA CTD PMID:27131904 Nlrp1a Rat silver(0) increases expression ISO RGD:1623841 6480464 Silver results in increased expression of NLRP1A mRNA CTD PMID:27131904 Nlrp1a Rat sodium arsenite affects methylation ISO RGD:1322162 6480464 sodium arsenite affects the methylation of NLRP1 gene CTD PMID:28589171 Nlrp1a Rat sodium arsenite multiple interactions ISO RGD:1322162 6480464 [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NLRP1 more ... CTD PMID:39836092 Nlrp1a Rat sodium arsenite increases expression ISO RGD:1322162 6480464 sodium arsenite results in increased expression of NLRP1 mRNA CTD PMID:38568856 Nlrp1a Rat sotorasib multiple interactions ISO RGD:1322162 6480464 [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NLRP1 mRNA CTD PMID:36139627 Nlrp1a Rat testosterone multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of NLRP1A mRNA CTD PMID:32741896 Nlrp1a Rat thiram increases expression ISO RGD:1322162 6480464 Thiram results in increased expression of NLRP1 mRNA CTD PMID:38568856 Nlrp1a Rat titanium dioxide multiple interactions ISO RGD:1623841 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of NLRP1A more ... CTD PMID:29950665 Nlrp1a Rat titanium dioxide increases expression ISO RGD:1623841 6480464 titanium dioxide results in increased expression of NLRP1A mRNA CTD PMID:35295148 Nlrp1a Rat trametinib multiple interactions ISO RGD:1322162 6480464 [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NLRP1 mRNA CTD PMID:36139627 Nlrp1a Rat triphenyl phosphate affects expression ISO RGD:1322162 6480464 triphenyl phosphate affects the expression of NLRP1 mRNA CTD PMID:37042841 Nlrp1a Rat valproic acid increases methylation ISO RGD:1322162 6480464 Valproic Acid results in increased methylation of NLRP1 gene CTD PMID:29154799 Nlrp1a Rat valproic acid increases expression ISO RGD:1322162 6480464 Valproic Acid results in increased expression of NLRP1 mRNA CTD PMID:19101580|PMID:24935251 Nlrp1a Rat valproic acid affects expression ISO RGD:1322162 6480464 Valproic Acid affects the expression of NLRP1 mRNA CTD PMID:25979313 Nlrp1a Rat zinc atom increases expression ISO RGD:1322162 6480464 Zinc deficiency results in increased expression of NLRP1 mRNA CTD PMID:22171008 Nlrp1a Rat zinc(0) increases expression ISO RGD:1322162 6480464 Zinc deficiency results in increased expression of NLRP1 mRNA CTD PMID:22171008
Biological Process
Only show annotations with direct experimental evidence (0 objects hidden)
Nlrp1a Rat activation of innate immune response involved_in IBA MGI:1931465|PANTHER:PTN005327833|UniProtKB:Q9C000|UniProtKB:Q9ULZ3|UniProtKB:Q9Y2G2 1600115 GO_REF:0000033 GO_Central GO_REF:0000033 Nlrp1a Rat antiviral innate immune response involved_in ISO RGD:1322162 1624291 PMID:33093214 RGD PMID:33093214 Nlrp1a Rat cellular response to UV-B involved_in ISO RGD:1322162 1624291 PMID:30096351 RGD PMID:30096351 Nlrp1a Rat defense response to bacterium acts_upstream_of_or_within ISO RGD:1623841 1624291 PMID:16429160 RGD PMID:16429160 Nlrp1a Rat defense response to virus involved_in ISO RGD:1322162 1624291 PMID:33093214, PMID:33243852 RGD PMID:33093214|PMID:33243852 Nlrp1a Rat immune system process involved_in IEA UniProtKB-KW:KW-0391 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Nlrp1a Rat inflammatory response involved_in IBA MGI:1931465|MGI:3582959|PANTHER:PTN005327833|UniProtKB:Q9C000|UniProtKB:Q9ULZ3|UniProtKB:Q9Y2G2 1600115 GO_REF:0000033 GO_Central GO_REF:0000033 Nlrp1a Rat inflammatory response involved_in IEA UniProtKB-KW:KW-0395 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Nlrp1a Rat inflammatory response involved_in IEA InterPro:IPR033516 1600115 GO_REF:0000002 InterPro GO_REF:0000002 Nlrp1a Rat innate immune response involved_in IEA UniProtKB-KW:KW-0399 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Nlrp1a Rat innate immune response involved_in IEA InterPro:IPR033516 1600115 GO_REF:0000002 InterPro GO_REF:0000002 Nlrp1a Rat intrinsic apoptotic signaling pathway involved_in IBA PANTHER:PTN005327833|UniProtKB:Q9ULZ3 1600115 GO_REF:0000033 GO_Central GO_REF:0000033 Nlrp1a Rat negative regulation of cellular defense response IMP 38549348 RGD Nlrp1a Rat negative regulation of cellular defense response involved_in IEA ARBA:ARBA00034579 1600115 GO_REF:0000117 UniProt GO_REF:0000117 Nlrp1a Rat neuron apoptotic process involved_in ISO RGD:1322162 1624291 PMID:15212762 RGD PMID:15212762 Nlrp1a Rat NLRP1 inflammasome complex assembly involved_in ISO RGD:1322162 1624291 PMID:22665479, PMID:27662089, PMID:31484767, PMID:33243852, PMID:33420028, PMID:33420033, PMID:33852854, PMID:35594856 RGD PMID:22665479|PMID:27662089|PMID:31484767|PMID:33243852|PMID:33420028|PMID:33420033|PMID:33852854|PMID:35594856 Nlrp1a Rat positive regulation of inflammatory response involved_in ISO RGD:1322162 1624291 PMID:12191486 RGD PMID:12191486 Nlrp1a Rat positive regulation of interleukin-1 beta production involved_in ISO RGD:1322162 1624291 PMID:33243852, PMID:7642516 RGD PMID:33243852|PMID:7642516 Nlrp1a Rat positive regulation of interleukin-1 beta production involved_in ISO RGD:1623841 1624291 PMID:18511561 RGD PMID:18511561 Nlrp1a Rat positive regulation of pyroptotic inflammatory response IMP 38549348 RGD Nlrp1a Rat positive regulation of pyroptotic inflammatory response involved_in IEA ARBA:ARBA00034588 1600115 GO_REF:0000117 UniProt GO_REF:0000117 Nlrp1a Rat programmed cell death involved_in IEA UniProtKB-KW:KW-1210 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Nlrp1a Rat programmed necrotic cell death acts_upstream_of_or_within ISO RGD:1623841 1624291 PMID:16429160 RGD PMID:16429160 Nlrp1a Rat protein homooligomerization involved_in ISS UniProtKB:Q9C000 1600115 GO_REF:0000024 UniProt GO_REF:0000024 Nlrp1a Rat protein homooligomerization involved_in ISO RGD:1322162,UniProtKB:Q9C000-PRO_0000452852 1624291 PMID:33731929 RGD PMID:33731929 Nlrp1a Rat protein homooligomerization involved_in ISO RGD:1322162 1624291 PMID:33420028, PMID:33420033 RGD PMID:33420028|PMID:33420033 Nlrp1a Rat proteolysis involved_in IEA UniProtKB-KW:KW-0645 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Nlrp1a Rat pyroptotic inflammatory response involved_in ISO RGD:1322162 1624291 PMID:33093214 RGD PMID:33093214 Nlrp1a Rat pyroptotic inflammatory response involved_in ISO RGD:1322162,UniProtKB:Q9C000-PRO_0000452852 1624291 PMID:33731929 RGD PMID:33731929 Nlrp1a Rat regulation of apoptotic process involved_in IEA InterPro:IPR001315 1600115 GO_REF:0000002 InterPro GO_REF:0000002 Nlrp1a Rat regulation of inflammatory response involved_in ISO RGD:1322162 1624291 PMID:15212762 RGD PMID:15212762 Nlrp1a Rat response to muramyl dipeptide involved_in ISO RGD:1623841 1624291 PMID:18511561 RGD PMID:18511561 Nlrp1a Rat self proteolysis involved_in ISO RGD:1322162 1624291 PMID:33093214 RGD PMID:33093214 Nlrp1a Rat signal transduction involved_in ISO RGD:1322162 1624291 PMID:30096351 RGD PMID:30096351
Molecular Function
Only show annotations with direct experimental evidence (0 objects hidden)
Nlrp1a Rat ATP binding enables IEA UniProtKB-KW:KW-0067 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Nlrp1a Rat ATP binding enables ISO RGD:1322162 1624291 PMID:15212762, PMID:33243852 RGD PMID:15212762|PMID:33243852 Nlrp1a Rat ATP hydrolysis activity enables ISO RGD:1322162 1624291 PMID:33243852 RGD PMID:33243852 Nlrp1a Rat cysteine-type endopeptidase activator activity enables ISS UniProtKB:Q9C000 1600115 GO_REF:0000024 UniProt GO_REF:0000024 Nlrp1a Rat cysteine-type endopeptidase activator activity enables ISO RGD:1322162 1624291 PMID:22665479, PMID:30291141, PMID:33852854, PMID:35594856 RGD PMID:22665479|PMID:30291141|PMID:33852854|PMID:35594856 Nlrp1a Rat cysteine-type endopeptidase activator activity enables IBA PANTHER:PTN005327833|UniProtKB:Q9C000|UniProtKB:Q9Y2G2 1600115 GO_REF:0000033 GO_Central GO_REF:0000033 Nlrp1a Rat double-stranded DNA binding enables ISO RGD:1322162 1624291 PMID:33243852 RGD PMID:33243852 Nlrp1a Rat double-stranded RNA binding enables ISO RGD:1322162 1624291 PMID:33243852 RGD PMID:33243852 Nlrp1a Rat endopeptidase activity enables ISO RGD:1322162,UniProtKB:Q9C000-PRO_0000096710 1624291 PMID:33731929 RGD PMID:33731929 Nlrp1a Rat enzyme binding enables ISO RGD:1322162 1624291 UniProtKB:P42575 PMID:11076957 RGD PMID:11076957 Nlrp1a Rat hydrolase activity enables IEA UniProtKB-KW:KW-0378 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Nlrp1a Rat molecular condensate scaffold activity enables ISO RGD:1322162 1624291 PMID:33420028, PMID:33420033 RGD PMID:33420028|PMID:33420033 Nlrp1a Rat nucleotide binding enables IEA UniProtKB-KW:KW-0547 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Nlrp1a Rat pattern recognition receptor activity enables IBA PANTHER:PTN005327833|UniProtKB:Q9C000|UniProtKB:Q9Y2G2 1600115 GO_REF:0000033 GO_Central GO_REF:0000033 Nlrp1a Rat pattern recognition receptor activity enables ISO RGD:1322162 1624291 PMID:33243852 RGD PMID:33243852 Nlrp1a Rat peptidase activity enables IEA UniProtKB-KW:KW-0645 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Nlrp1a Rat protein binding IPI RGD:735204 5491011 RGD Nlrp1a Rat protein binding enables ISO RGD:1623841 1624291 UniProtKB:Q80SY9 PMID:18511561 RGD PMID:18511561 Nlrp1a Rat protein binding enables ISO RGD:1322162,UniProtKB:Q9C000-PRO_0000452851 1624291 UniProtKB:F5HDE4 PMID:35618833 RGD PMID:35618833 Nlrp1a Rat protein binding enables ISO RGD:1322162 1624291 UniProtKB:P10415|UniProtKB:P19525|UniProtKB:P29466|UniProtKB:Q07817|UniProtKB:Q07817-1|UniProtKB:Q86TI2|UniProtKB:Q9HC29|UniProtKB:Q9NPP4|UniProtKB:Q9ULZ3 PMID:11472070, PMID:15107016, PMID:17418785, PMID:18511561, PMID:19223583, PMID:19337385, PMID:22801494, PMID:30291141, PMID:33731929 RGD PMID:11472070|PMID:15107016|PMID:17418785|PMID:18511561|PMID:19223583|PMID:19337385|PMID:22801494|PMID:30291141|PMID:33731929 Nlrp1a Rat protein domain specific binding enables ISO RGD:1322162 1624291 UniProtKB:O95361 PMID:16575408 RGD PMID:16575408 Nlrp1a Rat scaffold protein binding IPI RGD:628637 5491011 RGD Nlrp1a Rat scaffold protein binding enables IEA ARBA:ARBA00034605 1600115 GO_REF:0000117 UniProt GO_REF:0000117 Nlrp1a Rat signaling adaptor activity enables ISO RGD:1322162 1624291 PMID:22665479 RGD PMID:22665479
Imported Annotations - KEGG (archival)
1,2-dichloroethane (ISO) 17beta-estradiol (EXP,ISO) 17beta-estradiol 3-benzoate (EXP) 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) (ISO) 2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO) 4,4'-sulfonyldiphenol (EXP,ISO) acetamide (EXP) acrolein (ISO) acrylamide (ISO) actinomycin D (ISO) Aflatoxin B2 alpha (ISO) alpha-pinene (ISO) aristolochic acid A (ISO) arsane (ISO) arsenic atom (ISO) arsenite(3-) (ISO) arsenous acid (ISO) ATP (ISO) Azoxymethane (ISO) beauvericin (ISO) benzo[a]pyrene (ISO) benzo[a]pyrene diol epoxide I (ISO) benzo[e]pyrene (ISO) bisphenol A (EXP,ISO) bisphenol F (EXP) calcitriol (ISO) cantharidin (ISO) carbon nanotube (ISO) CGP 52608 (ISO) cisplatin (ISO) cobalt dichloride (ISO) copper atom (ISO) copper(0) (ISO) copper(II) sulfate (ISO) dextran sulfate (ISO) diarsenic trioxide (ISO) diazinon (EXP) Dibutyl phosphate (ISO) diclofenac (EXP) dicrotophos (ISO) doxorubicin (ISO) gallic acid (ISO) gentamycin (EXP) lipopolysaccharide (ISO) luteolin (EXP) mercury atom (ISO) mercury(0) (ISO) methapyrilene (ISO) Nutlin-3 (ISO) okadaic acid (ISO) ozone (ISO) p-menthan-3-ol (ISO) panobinostat (ISO) paracetamol (EXP) pinostrobin (ISO) resveratrol (ISO) sanguinarine (ISO) silver atom (ISO) silver(0) (ISO) sodium arsenite (ISO) sotorasib (ISO) testosterone (EXP) thiram (ISO) titanium dioxide (ISO) trametinib (ISO) triphenyl phosphate (ISO) valproic acid (ISO) zinc atom (ISO) zinc(0) (ISO)
1.
Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii.
Cirelli KM, etal., PLoS Pathog. 2014 Mar 13;10(3):e1003927. doi: 10.1371/journal.ppat.1003927. eCollection 2014 Mar.
2.
Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury.
de Rivero Vaccari JP, etal., J Cereb Blood Flow Metab. 2009 Jul;29(7):1251-61. Epub 2009 Apr 29.
3.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.
OMIM Disease Annotation Pipeline
OMIM Disease Annotation Pipeline
5.
KEGG Annotation Import Pipeline
Pipeline to import KEGG annotations from KEGG into RGD
6.
ClinVar Automated Import and Annotation Pipeline
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
8.
The inflammasomes.
Schroder K and Tschopp J, Cell. 2010 Mar 19;140(6):821-32. doi: 10.1016/j.cell.2010.01.040.
9.
The pannexin 1 channel activates the inflammasome in neurons and astrocytes.
Silverman WR, etal., J Biol Chem. 2009 Jul 3;284(27):18143-51. Epub 2009 May 5.
Nlrp1a Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 10 56,277,134 - 56,332,229 (-) NCBI GRCr8 mRatBN7.2 10 55,778,560 - 55,833,639 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 10 55,778,560 - 55,825,180 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 10 60,458,304 - 60,504,924 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 10 59,946,824 - 59,993,447 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 10 55,445,908 - 55,492,512 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 10 57,692,474 - 57,747,608 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 10 57,692,474 - 57,822,498 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 10 57,437,815 - 57,492,207 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 10 57,963,708 - 58,007,925 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 10 57,960,835 - 58,122,088 (-) NCBI Celera 10 54,924,259 - 54,970,955 (-) NCBI Celera Cytogenetic Map 10 q24 NCBI
NLRP1 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 17 5,501,396 - 5,584,509 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 17 5,499,415 - 5,619,424 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 17 5,404,716 - 5,487,829 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 17 5,345,443 - 5,428,556 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Celera 17 5,421,095 - 5,503,841 (-) NCBI Celera Cytogenetic Map 17 p13.2 NCBI HuRef 17 5,294,862 - 5,377,604 (-) NCBI HuRef CHM1_1 17 5,414,362 - 5,497,490 (-) NCBI CHM1_1 T2T-CHM13v2.0 17 5,395,133 - 5,478,273 (-) NCBI T2T-CHM13v2.0
Nlrp1a Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 11 70,982,023 - 71,035,780 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 11 70,983,062 - 71,035,530 (-) Ensembl GRCm39 Ensembl GRCm38 11 71,091,197 - 71,144,969 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 11 71,092,236 - 71,144,704 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 11 70,904,699 - 70,958,206 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 11 70,908,431 - 70,958,561 (-) NCBI MGSCv36 mm8 Celera 11 78,634,796 - 78,688,328 (-) NCBI Celera Cytogenetic Map 11 B4 NCBI cM Map 11 43.21 NCBI
NLRP1 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 19 13,096,919 - 13,194,847 (-) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 17 15,079,526 - 15,162,296 (-) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 17 5,562,129 - 5,667,765 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 17 5,541,559 - 5,623,659 (-) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 17 5,542,007 - 5,623,091 (-) Ensembl panpan1.1 panPan2
NLRP1 Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 5 31,264,554 - 31,299,538 (+) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 5 31,266,621 - 31,299,304 (+) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 5 31,399,983 - 31,440,503 (+) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 5 31,369,269 - 31,407,109 (+) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 5 31,370,391 - 31,404,052 (+) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 5 31,334,819 - 31,372,650 (+) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 5 31,293,857 - 31,331,580 (+) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 5 31,467,813 - 31,507,973 (+) NCBI UU_Cfam_GSD_1.0
Nlrp1 Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024405602 53,611,186 - 53,653,113 (-) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936677 2,248,903 - 2,289,151 (+) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936677 2,248,153 - 2,290,802 (+) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
NLRP1
NLRP1
.
Predicted Target Of
Count of predictions: 83 Count of miRNA genes: 78 Interacting mature miRNAs: 78 Transcripts: ENSRNOT00000037546 Prediction methods: Microtar, Miranda, Rnahybrid Result types: miRGate_prediction
61441 Btemp1 Thermal response to stress QTL 1 4 body temperature trait (VT:0005535) core body temperature (CMO:0001036) 10 35392457 63642539 Rat 1549846 Scl47 Serum cholesterol level QTL 47 3.6 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) 10 50574707 95574707 Rat 9589136 Insul27 Insulin level QTL 27 10.46 0.001 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 10 11474010 56474010 Rat 152025229 Scl83 Serum cholesterol level QTL 83 4.33 blood cholesterol amount (VT:0000180) 10 35710580 68663659 Rat 1578779 Tcas10 Tongue tumor susceptibility QTL 10 3.12 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) 10 31297439 76297439 Rat 152025227 Bw195 Body weight QTL 195 5.73 body mass (VT:0001259) 10 46989699 68663659 Rat 631564 Apr3 Acute phase response QTL 3 3.9 blood interleukin-6 amount (VT:0008595) plasma interleukin-6 level (CMO:0001927) 10 15275955 60275955 Rat 1298069 Bp168 Blood pressure QTL 168 5.5 blood pressure trait (VT:0000183) systolic blood pressure (CMO:0000004) 10 26521957 98003205 Rat 2293669 Bmd33 Bone mineral density QTL 33 4.5 0.0001 femur strength trait (VT:0010010) femoral neck polar moment of inertia (CMO:0001670) 10 49444551 81709989 Rat 152025224 Bw193 Body weight QTL 193 6.47 body mass (VT:0001259) 10 51663405 75085664 Rat 631552 Vetf2 Vascular elastic tissue fragility QTL 2 4.5 0.0002 aorta elastic tissue integrity trait (VT:0010556) artery internal elastic lamina non-tumorous lesion count (CMO:0001913) 10 41142633 86142633 Rat 631554 Bp133 Blood pressure QTL 133 0.005 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 10 743364 63851208 Rat 631557 Bp136 Blood pressure QTL 136 0.003 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 10 30632053 75632053 Rat 61325 Aia5 Adjuvant induced arthritis QTL 5 0.01 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 10 23444813 104060283 Rat 1298078 Stresp5 Stress response QTL 5 2.99 0.00025 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 10 42045676 104670812 Rat 2293679 Bmd30 Bone mineral density QTL 30 3.5 0.0001 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) 10 49444551 81709989 Rat 1578762 Toxo1 Toxoplasma gondii resistance QTL 1 brain integrity trait (VT:0010579) percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028) 10 52200030 59378278 Rat 2298544 Neuinf9 Neuroinflammation QTL 9 4.6 nervous system integrity trait (VT:0010566) spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126) 10 5801990 62146030 Rat 70164 Bw21 Body weight QTL 21 4.36 0.00005 body mass (VT:0001259) body weight (CMO:0000012) 10 53797494 98952626 Rat 61463 Bp12 Blood pressure QTL 12 6.3 0.0001 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 10 41333258 86333258 Rat 8694173 Bw149 Body weight QTL 149 4.38 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 10 44441699 89441699 Rat 2300218 Hpcl2 Hepatic cholesterol level QTL 2 liver cholesterol amount (VT:0010498) liver cholesterol level (CMO:0001597) 10 45029650 95600334 Rat 1554317 Bmd4 Bone mineral density QTL 4 9.4 0.0001 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) 10 19816042 99406971 Rat 70171 Cari1 Carrageenan-induced inflammation QTL 1 4.9 0.0005 hypodermis integrity trait (VT:0010550) inflammatory exudate volume (CMO:0001429) 10 53797385 107211142 Rat 1598852 Anxrr19 Anxiety related response QTL 19 5.07 body movement coordination trait (VT:0005424) number of rearing movements in an experimental apparatus (CMO:0001752) 10 18167841 63167841 Rat 1581497 Esta1 Estrogen-induced thymic atrophy QTL 1 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) 10 21329805 61345413 Rat 724527 Bp148 Blood pressure QTL 148 0.0001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 10 28453136 73453136 Rat 1358897 Stresp6 Stress response QTL 6 4.17 0.022 blood norepinephrine amount (VT:0005663) plasma norepinephrine level (CMO:0001010) 10 35392267 64155584 Rat 1331762 Rf40 Renal function QTL 40 3.873 kidney blood vessel physiology trait (VT:0100012) absolute change in renal vascular resistance (CMO:0001900) 10 29299504 64155584 Rat 2300171 Bmd58 Bone mineral density QTL 58 4.9 0.0001 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) 10 26944628 71944628 Rat 61354 Pia10 Pristane induced arthritis QTL 10 0.01 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 10 23444813 104060283 Rat 2301967 Cm73 Cardiac mass QTL 73 4.55 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 10 14487011 89062041 Rat 2303118 Mamtr7 Mammary tumor resistance QTL 7 0.003 mammary gland integrity trait (VT:0010552) mammary tumor growth rate (CMO:0000344) 10 9658275 104670812 Rat 70188 BpQTLcluster1 Blood pressure QTL cluster 1 4.864 arterial blood pressure trait (VT:2000000) pulse pressure (CMO:0000292) 1 42323132 87323132 Rat 9590310 Scort19 Serum corticosterone level QTL 19 6.3 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 10 11474010 56474010 Rat 9589030 Epfw9 Epididymal fat weight QTL 9 19.24 0.001 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) 10 44441699 89441699 Rat 10402859 Bp381 Blood pressure QTL 381 0.002 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 10 27606468 72606468 Rat 2316949 Gluco60 Glucose level QTL 60 3.7 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 10 14487011 107057807 Rat 2293652 Bmd22 Bone mineral density QTL 22 4.9 0.0001 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) 10 49444551 81709989 Rat 70198 BpQTLcluster9 Blood pressure QTL cluster 9 2.94 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 10 42323132 87323132 Rat 1359017 Hrtrt21 Heart rate QTL 21 2.4 heart pumping trait (VT:2000009) heart rate (CMO:0000002) 10 51772940 96772940 Rat 2306787 Ean3 Experimental allergic neuritis QTL 3 3.1 nervous system integrity trait (VT:0010566) body weight loss (CMO:0001399) 10 53797385 66979128 Rat 6893352 Bw100 Body weight QTL 100 0.33 0.6 body mass (VT:0001259) body weight (CMO:0000012) 1 15906665 60906665 Rat 724556 Pur2 Proteinuria QTL 2 5.5 urine protein amount (VT:0005160) urine protein level (CMO:0000591) 10 22427500 90627625 Rat 8662860 Vetf10 Vascular elastic tissue fragility QTL 10 artery integrity trait (VT:0010639) number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562) 10 6154182 73453136 Rat 61387 Bp1 Blood pressure QTL 1 5.1 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 10 51770177 107211142 Rat 1354585 Eae18a Experimental allergic encephalomyelitis QTL 18a 7.5 0.0004 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) 10 53797385 58445852 Rat 70223 Bp57 Blood pressure QTL 57 5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 10 1 80676123 Rat 1354587 Kidm21 Kidney mass QTL 21 3.3 kidney mass (VT:0002707) right kidney wet weight (CMO:0000082) 10 15028513 60430477 Rat 6893350 Bw99 Body weight QTL 99 0.87 0.16 body mass (VT:0001259) body weight (CMO:0000012) 1 15906665 60906665 Rat 2317043 Aia7 Adjuvant induced arthritis QTL 7 3.82 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) 10 37565079 82565079 Rat 70224 Eae3 Experimental allergic encephalomyelitis QTL 3 4.1 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) 10 26521957 61345413 Rat 2317042 Aia20 Adjuvant induced arthritis QTL 20 3.38 joint integrity trait (VT:0010548) right rear ankle joint diameter (CMO:0002150) 10 37565079 82565079 Rat 1331791 Cm31 Cardiac mass QTL 31 3.84606 heart mass (VT:0007028) heart wet weight (CMO:0000069) 10 29299504 107211142 Rat 2313087 Bmd80 Bone mineral density QTL 80 3.2 0.0001 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) 10 19606483 64606483 Rat 2298495 Eae23 Experimental allergic encephalomyelitis QTL 23 16.93 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis duration (CMO:0001424) 10 55273696 60677262 Rat 70364 Bp72 Blood pressure QTL 72 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 10 51121100 96121100 Rat 631530 Tls3 T-lymphoma susceptibility QTL 3 0 0.0001 thymus integrity trait (VT:0010555) percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911) 10 51774612 95600334 Rat 1354608 Cm33 Cardiac mass QTL 33 2.8 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) 10 54809292 99809292 Rat 631535 Cm51 Cardiac mass QTL 51 3 heart mass (VT:0007028) calculated heart weight (CMO:0000073) 10 51786282 91669536 Rat 1576319 Cia29 Collagen induced arthritis QTL 29 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 10 33973921 78973921 Rat 8552805 Bw145 Body weight QTL 145 2.2 body mass (VT:0001259) change in body weight to body weight ratio (CMO:0002216) 10 41944526 78307017 Rat 631267 Cia20 Collagen induced arthritis QTL 20 3.2 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 10 23444813 104060283 Rat 2293705 Bmd25 Bone mineral density QTL 25 7.1 0.0001 femur mineral mass (VT:0010011) compact volumetric bone mineral density (CMO:0001730) 10 49444551 81709989 Rat 1576308 Schws1 Schwannoma susceptibility QTL 1 0.0041 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) 10 40035094 102359817 Rat 631269 Cia22 Collagen induced arthritis QTL 22 8.9 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 10 40035094 104060283 Rat 631268 Cia21 Collagen induced arthritis QTL 21 3.1 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 10 14487011 104060283 Rat 9590268 Scort13 Serum corticosterone level QTL 13 3.26 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 10 11474010 56474010 Rat 7207811 Bmd90 Bone mineral density QTL 90 5.2 femur size trait (VT:1000369) femoral neck cross-sectional area (CMO:0001697) 10 49444551 81709989 Rat 1576311 Pia26 Pristane induced arthritis QTL 26 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 10 31224026 75632053 Rat 631270 Cia23 Collagen induced arthritis QTL 23 3.9 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 10 40035094 104060283 Rat 7411614 Foco18 Food consumption QTL 18 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 10 44441699 89441699 Rat 631547 Bp87 Blood pressure QTL 87 4.5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 10 47369470 92369470 Rat 61427 Cia16 Collagen induced arthritis QTL 16 3.2 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 10 6357896 96121100 Rat 6893342 Cm78 Cardiac mass QTL 78 0.1 0.88 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 10 42876766 79813922 Rat 2292441 Bp308 Blood pressure QTL 308 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 10 27606468 72606468 Rat 2313055 Bw96 Body weight QTL 96 3.6 0.0001 body mass (VT:0001259) body weight (CMO:0000012) 10 19606483 64606483 Rat 631542 Bp82 Blood pressure QTL 82 6.8 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 10 26521957 98952741 Rat
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
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49
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91
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25
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Ensembl Acc Id:
ENSRNOT00000037546 ⟹ ENSRNOP00000034130
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 10 55,781,885 - 55,825,138 (-) Ensembl Rnor_6.0 Ensembl 10 57,695,802 - 57,822,498 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000082171 ⟹ ENSRNOP00000073609
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 10 55,778,560 - 55,825,180 (-) Ensembl Rnor_6.0 Ensembl 10 57,692,474 - 57,739,109 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000093906 ⟹ ENSRNOP00000089800
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 10 55,781,885 - 55,825,180 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000094927 ⟹ ENSRNOP00000091173
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 10 55,778,560 - 55,825,138 (-) Ensembl
RefSeq Acc Id:
NM_001145755 ⟹ NP_001139227
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 10 56,277,134 - 56,323,756 (-) NCBI mRatBN7.2 10 55,778,560 - 55,825,180 (-) NCBI Rnor_6.0 10 57,692,474 - 57,739,109 (-) NCBI Rnor_5.0 10 57,437,815 - 57,492,207 (-) NCBI RGSC_v3.4 10 57,963,708 - 58,007,925 (-) RGD Celera 10 54,924,259 - 54,970,955 (-) NCBI
Sequence:
AAACCATATCTGAGAGAAACCATATCTGAGGACCCCATCACTATGGAAGAATCTCAGTCCAAGCAGGAAAGTAACACAAGGGTGGCTCAGCATGGAAGCCAACAGGATGTGGACCCCACCTTCCAAAC
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RefSeq Acc Id:
XM_006246755 ⟹ XP_006246817
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 10 56,277,134 - 56,332,229 (-) NCBI mRatBN7.2 10 55,778,560 - 55,833,639 (-) NCBI Rnor_6.0 10 57,692,474 - 57,747,608 (-) NCBI Rnor_5.0 10 57,437,815 - 57,492,207 (-) NCBI
Sequence:
TCTGCAGAGACTGTTACAGGAAACAAGCTGAAGGACGCATCTGCATAAGCTTTGGTGCCAGACTTCCTGGTCCGGAATCAGAGTCACTTTCACTTTTGAAGAACAAGTTTTTTAGGTGAAGAGTCTTG
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RefSeq Acc Id:
XM_039086323 ⟹ XP_038942251
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 10 56,277,134 - 56,332,229 (-) NCBI mRatBN7.2 10 55,781,483 - 55,833,639 (-) NCBI
RefSeq Acc Id:
XM_039086324 ⟹ XP_038942252
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 10 56,277,134 - 56,332,202 (-) NCBI mRatBN7.2 10 55,781,483 - 55,824,986 (-) NCBI
RefSeq Acc Id:
XM_039086325 ⟹ XP_038942253
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 10 56,306,215 - 56,332,225 (-) NCBI mRatBN7.2 10 55,807,638 - 55,833,639 (-) NCBI
RefSeq Acc Id:
XR_005489886
Type:
NON-CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 10 56,281,155 - 56,332,225 (-) NCBI mRatBN7.2 10 55,782,581 - 55,833,639 (-) NCBI
RefSeq Acc Id:
NP_001139227 ⟸ NM_001145755
- UniProtKB:
D9I2G3 (UniProtKB/Swiss-Prot), A0A0G2QC28 (UniProtKB/Swiss-Prot), F1LPA5 (UniProtKB/Swiss-Prot), D9I2F9 (UniProtKB/TrEMBL)
- Sequence:
MEESQSKQESNTRVAQHGSQQDVDPTFQTKRALEKERSKPRPRPLPRVQLQSLPGWSSTSNDVPLSQLIREMDHESRRCIHRSKKKLDRSEHISQGTIPEIYEKRKETISHTQSMEQKYLFQNFTKLL
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RefSeq Acc Id:
XP_006246817 ⟸ XM_006246755
- Peptide Label:
isoform X1
- UniProtKB:
D9I2G3 (UniProtKB/Swiss-Prot), A0A0G2QC28 (UniProtKB/Swiss-Prot), F1LPA5 (UniProtKB/Swiss-Prot), D9I2F9 (UniProtKB/TrEMBL)
- Sequence:
MEESQSKQESNTRVAQHGSQQDVDPTFQTKRALEKERSKPRPRPLPRVQLQSLPGWSSTSNDVPLSQLIREMDHESRRCIHRSKKKLDRSEHISQGTIPEIYEKRKETISHTQSMEQKYLFQNFTKLL
hide sequence
Ensembl Acc Id:
ENSRNOP00000073609 ⟸ ENSRNOT00000082171
Ensembl Acc Id:
ENSRNOP00000034130 ⟸ ENSRNOT00000037546
RefSeq Acc Id:
XP_038942251 ⟸ XM_039086323
- Peptide Label:
isoform X2
- UniProtKB:
D9I2H0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id:
XP_038942252 ⟸ XM_039086324
- Peptide Label:
isoform X3
- UniProtKB:
D9I2G3 (UniProtKB/Swiss-Prot)
RefSeq Acc Id:
XP_038942253 ⟸ XM_039086325
- Peptide Label:
isoform X4
Ensembl Acc Id:
ENSRNOP00000091173 ⟸ ENSRNOT00000094927
Ensembl Acc Id:
ENSRNOP00000089800 ⟸ ENSRNOT00000093906
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2011-02-18
Nlrp1a
NLR family, pyrin domain containing 1A
Nlrp1
NLR family, pyrin domain containing 1
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2009-06-15
Nlrp1
NLR family, pyrin domain containing 1
LOC687766
similar to NACHT, leucine rich repeat and PYD containing 1
Data merged from RGD:1597519
1643240 APPROVED
2009-06-15
Nlrp1
NLR family, pyrin domain containing 1
LOC687763
similar to NACHT, leucine rich repeat and PYD containing 1
Data merged from RGD:1597522
1643240 APPROVED
2008-09-26
Nlrp1
NLR family, pyrin domain containing 1
Nlrp1a
NLR family, pyrin domain containing 1A
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2008-03-04
Nlrp1a
NLR family, pyrin domain containing 1A
Nalp1_predicted
NACHT, leucine rich repeat and PYD containing 1 (predicted)
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2006-11-20
LOC687763
similar to NACHT, leucine rich repeat and PYD containing 1
Symbol and Name status set to provisional
70820 PROVISIONAL
2006-11-20
LOC687766
similar to NACHT, leucine rich repeat and PYD containing 1
Symbol and Name status set to provisional
70820 PROVISIONAL
2005-01-12
Nalp1_predicted
NACHT, leucine rich repeat and PYD containing 1 (predicted)
Symbol and Name status set to approved
70820 APPROVED
