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Gene: CARD8 (caspase recruitment domain family member 8) Homo sapiens
Symbol: CARD8
Name: caspase recruitment domain family member 8
RGD ID: 1351599
Description: Exhibits cysteine-type endopeptidase activator activity involved in apoptotic process; protein domain specific binding activity; and protein homodimerization activity. Involved in negative regulation of signal transduction; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; and regulation of gene expression. Localizes to NLRP3 inflammasome complex and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apoptotic protein NDPP1; CARD inhibitor of NF-kappaB-activating ligands; CARDINAL; caspase recruitment domain family, member 8; caspase recruitment domain-containing protein 8; DACAR; Dakar; DKFZp779L0366; FLJ18119; FLJ18121; KIAA0955; MGC57162; NDPP; NDPP1; TUCAN; tumor up-regulated CARD-containing antagonist of CASP9; tumor up-regulated CARD-containing antagonist of caspase nine
Rattus norvegicus (Norway rat) : Nlrp1b (NLR family, pyrin domain containing 1B)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100969375 (caspase recruitment domain-containing protein 8)
Canis lupus familiaris (dog) : CARD8 (caspase recruitment domain family, member 8)
Chlorocebus sabaeus (African green monkey) : CARD8 (caspase recruitment domain family member 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1948,180,770 - 48,255,946 (-)EnsemblGRCh38hg38GRCh38
GRCh381948,203,148 - 48,256,264 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371948,711,343 - 48,759,203 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,403,325 - 53,444,737 (-)NCBINCBI36hg18NCBI36
Build 341953,403,324 - 53,444,734NCBI
Celera1945,576,569 - 45,624,446 (-)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1945,093,304 - 45,141,176 (-)NCBIHuRef
CHM1_11948,713,493 - 48,761,345 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CARD8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1351599
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.