Eae18a QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Eae18a (Experimental allergic encephalomyelitis QTL 18a) Rattus norvegicus

Symbol: Eae18a
Name: Experimental allergic encephalomyelitis QTL 18a
RGD ID: 1354585
Previously known as: Experimental autoimmune encephalomyelitis QTL 18a; Eae19; Experimental allergic encephalomyelitis QTL 19
Trait: nervous system integrity trait   (VT:0010566)    
Measurement Type: experimental autoimmune encephalomyelitis severity score   (CMO:0001419)    
LOD Score: 7.5
P Value: 4.0E-4
Variance: Not Available
Inheritance Type: additive
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81054,296,227 - 58,944,345RGD_MAPPER_PIPELINE
mRatBN7.21053,797,385 - 58,445,852RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01055,678,976 - 60,404,791RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01055,422,036 - 60,141,913RGDRnor5.0
RGSC_v3.41055,851,702 - 60,865,280RGDRGSC3.4
Cross Type: Intercross
Strains Crossed: DA.ACI-(D10Rat219-D10Rat29) 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eae18aRatExperimental Autoimmune Encephalomyelitis  QTM 1302437 RGD 
Eae18aRatmultiple sclerosis  QTM 1302437 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eae18aRatparalysis  QTM 1302437 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eae18aRatexperimental autoimmune encephalomyelitis severity score  IDA 1302437 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eae18aRatmyelin oligodendrocyte glycoprotein  IDA 1302437 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eae18aRatin vivo visual assessment  IDA 1302437 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eae18aRatDA.ACI-(D10Rat219-D10Rat29)  IEA 1302437 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eae18aRatnervous system integrity trait  IDA 1302437 RGD 


#
Reference Title
Reference Citation
1. Advanced intercross line mapping suggests that ncf1 (ean6) regulates severity in an animal model of guillain-barre syndrome. Huberle A, etal., J Immunol. 2009 Apr 1;182(7):4432-8.
2. An advanced intercross line resolves Eae18 into two narrow quantitative trait loci syntenic to multiple sclerosis candidate loci. Jagodic M, etal., J Immunol 2004 Jul 15;173(2):1366-73.
3. Definition of a 1.06-Mb region linked to neuroinflammation in humans, rats and mice. Ockinger J, etal., Genetics. 2006 Jul;173(3):1539-45. Epub 2006 Apr 19.

Related QTL Description Reference
Ean3 maps to same region RGD:2306769
Eae23 sub_region RGD:2293859



1 to 20 of 216 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
3949Vamp2vesicle-associated membrane protein 2105379358153797815Rat
727863Per1period circadian regulator 1105380012653814963Rat
11499743Trnat-agu4transfer RNA threonine (anticodon AGU) 4105381545753815530Rat
11393487Trnas-cga2transfer RNA serine (anticodon CGA) 2105381594853816029Rat
9313918LOC103693354uncharacterized LOC103693354105382390453827703Rat
11415587Trnag-gcc2transfer RNA glycine (anticodon GCC) 2105382396053824030Rat
1305914Hes7hes family bHLH transcription factor 7105382412453828934Rat
11505532Trnar-ucu4transfer RNA arginine (anticodon UCU) 4105382851753828603Rat
11458838Trnal-uag2transfer RNA leucine (anticodon UAG) 2105382911953829200Rat
11413702Trnaq-cug6transfer RNA glutamine (anticodon CUG) 6105382948953829560Rat
11497110Trnak-uuu4transfer RNA lysine (anticodon UUU) 4105383004653830118Rat
1306252Aloxe3arachidonate epidermal lipoxygenase 3105383021953854328Rat
2323798Rpl37al1ribosomal protein L37A like 1105385911753859712Rat
1305330Alox12barachidonate 12-lipoxygenase, 12R type105386306053874938Rat
628809Alox15barachidonate 15-lipoxygenase, type B105389249653901812Rat
620438Gucy2eguanylate cyclase 2E105395491853975576Rat
41021983LOC120095371U6 spliceosomal RNA105397692453977028Rat
1307488Cntrobcentrobin, centriole duplication and spindle assembly protein105402252354047793Rat
1311365Trappc1trafficking protein particle complex subunit 1105404559854047184Rat
61830Kcnab3potassium voltage-gated channel subfamily A regulatory beta subunit 3105404783054056401Rat

1 to 20 of 216 rows
1 to 20 of 134 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10195D10Wox14158105477580754775965Ratregion
10196D10Mgh22270105477574554776015Ratregion
10664D10Uwm1158105467188954672047Ratregion
34320D10Mgh7215105409867454098889Ratregion
11288D10Wox1295105433337554333470Ratregion
11479D10Mit8109105379738553797494Ratregion
36087D10Rat156171105480929254809463Ratregion
36233D10Rat60161105505021355050374Ratregion
37564D10Rat77212105477429154774503Ratregion
36842DXRat1224105516225055162474Ratregion
36713D10Rat61259105481004554810306Ratregion
39588D1Rat297247105645849456458731Ratregion
39762D10Rat160205105678659656786787Ratregion
41943D10Arb6223105477579154776014Ratregion
41945D10Arb7301105379725053797551Ratregion
41947D10Arb8244105433337654333620Ratregion
42923D10Rat241222105770518957705411Ratregion
41092D10Rat158200105587313655873336Ratregion
1303357D10Got165141105554920155549342Ratregion
1303359D10Got166232105844562058445852Ratregion
1 to 20 of 134 rows

Flank 1: (D10Mit8)
Rat AssemblyChrPosition (strand)Source
GRCr81054,296,227 - 54,296,336 (+)Marker Load Pipeline
mRatBN7.21053,797,385 - 53,797,494 (+)MAPPER
Rnor_6.01055,678,976 - 55,679,084NCBI
Rnor_5.01055,422,036 - 55,422,144UniSTS
RGSC_v3.41055,851,702 - 55,851,811RGD
RGSC_v3.41055,851,703 - 55,851,811UniSTS
RGSC_v3.11055,865,325 - 55,865,434RGD
Celera1052,962,925 - 52,963,033UniSTS
SHRSP x BN Map1046.5699UniSTS
SHRSP x BN Map1046.5699RGD
Cytogenetic Map10q24UniSTS
Peak: (D10Got165)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21055,549,201 - 55,549,342 (+)MAPPER
Rnor_6.01057,457,227 - 57,457,367NCBI
Rnor_5.01057,203,327 - 57,203,467UniSTS
Rnor_5.01057,203,326 - 57,203,467NCBI
RGSC_v3.41057,729,579 - 57,729,719UniSTS
Celera1054,695,357 - 54,695,488UniSTS
Cytogenetic Map10 RGD
Flank 2: (D10Got166)
Rat AssemblyChrPosition (strand)Source
GRCr81058,944,113 - 58,944,345 (+)Marker Load Pipeline
mRatBN7.21058,445,620 - 58,445,852 (+)MAPPER
Rnor_6.01060,404,560 - 60,404,791NCBI
Rnor_5.01060,141,681 - 60,141,913NCBI
Rnor_5.01060,141,682 - 60,141,913UniSTS
RGSC_v3.41060,865,049 - 60,865,280UniSTS
Celera1057,509,496 - 57,509,727UniSTS
Cytogenetic Map10q24UniSTS


1 to 10 of 83 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat

1 to 10 of 83 rows


Database
Acc Id
Source(s)
NCBI Gene Eae18a


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-04-14 Eae18a  Experimental allergic encephalomyelitis QTL 18a  Eae19  Experimental allergic encephalomyelitis QTL 19  Symbol and Name updated 1299863 APPROVED

Note Type Note Reference
qtl_cross_type Intercross  
qtl_disease syntenic region on human chromosome 17p13 displays linkage to multiple sclerosis 1302437
qtl_statistics_details Values for incidence, cumulative score, duration and onset were also statistically significant (LOD >= 5.8, p<=0.05).