Eae18a QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Eae18a (Experimental allergic encephalomyelitis QTL 18a) Rattus norvegicus

Symbol: Eae18a
Name: Experimental allergic encephalomyelitis QTL 18a
RGD ID: 1354585
Previously known as: Experimental autoimmune encephalomyelitis QTL 18a; Eae19; Experimental allergic encephalomyelitis QTL 19
Trait: nervous system integrity trait   (VT:0010566)    
Measurement Type: experimental autoimmune encephalomyelitis severity score   (CMO:0001419)    
LOD Score: 7.5
P Value: 4.0E-4
Variance: Not Available
Inheritance Type: additive
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21053,797,385 - 58,445,852RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01055,678,976 - 60,404,791RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01055,422,036 - 60,141,913RGDRnor5.0
RGSC_v3.41055,851,702 - 60,865,280RGDRGSC3.4
Cross Type: Intercross
Strains Crossed: DA.ACI-(D10Rat219-D10Rat29) 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
paralysis  (QTM)
Experimental Data Annotations     Click to see Annotation Detail View

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Advanced intercross line mapping suggests that ncf1 (ean6) regulates severity in an animal model of guillain-barre syndrome. Huberle A, etal., J Immunol. 2009 Apr 1;182(7):4432-8.
2. An advanced intercross line resolves Eae18 into two narrow quantitative trait loci syntenic to multiple sclerosis candidate loci. Jagodic M, etal., J Immunol 2004 Jul 15;173(2):1366-73.
3. Definition of a 1.06-Mb region linked to neuroinflammation in humans, rats and mice. Ockinger J, etal., Genetics. 2006 Jul;173(3):1539-45. Epub 2006 Apr 19.
Related QTLs

Related QTL Description Reference
Ean3 maps to same region RGD:2306769
Eae23 sub_region RGD:2293859


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
3949Vamp2vesicle-associated membrane protein 2105379358153797815Rat
727863Per1period circadian regulator 1105380012653814963Rat
11499743Trnat-agu4transfer RNA threonine (anticodon AGU) 4105381545753815530Rat
11393487Trnas-cga2transfer RNA serine (anticodon CGA) 2105381594853816029Rat
9313918LOC103693354uncharacterized LOC103693354105382390453827703Rat
11415587Trnag-gcc2transfer RNA glycine (anticodon GCC) 2105382396053824030Rat
1305914Hes7hes family bHLH transcription factor 7105382412453828934Rat
11505532Trnar-ucu4transfer RNA arginine (anticodon UCU) 4105382851753828603Rat
11458838Trnal-uag2transfer RNA leucine (anticodon UAG) 2105382911953829200Rat
11413702Trnaq-cug6transfer RNA glutamine (anticodon CUG) 6105382948953829560Rat
11497110Trnak-uuu4transfer RNA lysine (anticodon UUU) 4105383004653830118Rat
1306252Aloxe3arachidonate epidermal lipoxygenase 3105383021953854328Rat
2323798Rpl37al1ribosomal protein L37A like 1105385911753859712Rat
1305330Alox12barachidonate 12-lipoxygenase, 12R type105386306053874938Rat
628809Alox15barachidonate 15-lipoxygenase, type B105389249653901812Rat
620438Gucy2eguanylate cyclase 2E105395491853975576Rat
41021983LOC120095371U6 spliceosomal RNA105397692453977028Rat
1307488Cntrobcentrobin, centriole duplication and spindle assembly protein105402252354047793Rat
1311365Trappc1trafficking protein particle complex subunit 1105404559854047184Rat
61830Kcnab3potassium voltage-gated channel subfamily A regulatory beta subunit 3105404783054056401Rat
1563441Rnf227ring finger protein 227105406105454063015Rat
1311923Chd3chromodomain helicase DNA binding protein 3105406362954090030Rat
41160913Scarna21small Cajal body-specific RNA 21105407095954071098Rat
1559567Cyb5d1cytochrome b5 domain containing 1105411342854117744Rat
1559617Naa38N(alpha)-acetyltransferase 38, NatC auxiliary subunit105411775454118913Rat
1561781Tmem88transmembrane protein 88105411875254120447Rat
1307629Kdm6blysine demethylase 6B105412071654142212Rat
1565087Dnah2dynein, axonemal, heavy chain 2105414264854268901Rat
7527073LOC102557224uncharacterized LOC102557224105419771454201762Rat
2541Efnb3ephrin B3105427450654281951Rat
1359624Wrap53WD repeat containing, antisense to TP53105428209254299908Rat
3889Tp53tumor protein p53105430007054311525Rat
2171Atp1b2ATPase Na+/K+ transporting subunit beta 2105431869854324933Rat
3671Shbgsex hormone binding globulin105433293954350409Rat
1307869Sat2spermidine/spermine N1-acetyltransferase family member 2105434075654343507Rat
1307011Fxr2FMR1 autosomal homolog 2105435057754370964Rat
1312022Sox15SRY-box transcription factor 15105437304554374749Rat
1307699Mpdu1mannose-P-dolichol utilization defect 1105437471954380301Rat
1305970Cd68Cd68 molecule105438181454383693Rat
735141Eif4a1eukaryotic translation initiation factor 4A1105438434554389855Rat
41317947Snora67small nucleolar RNA, H/ACA box 67105438527654385418Rat
40947074Snord10small nucleolar RNA, C/D box 10105438629054386431Rat
41267437LOC120095433small nucleolar RNA SNORA48105438718554387327Rat
41212261Eif4a1leukaryotic translation initiation factor 4A1 like105438903054402545Rat
1312040Senp3SUMO specific peptidase 3105439069854399590Rat
1305871Tnfsf13TNF superfamily member 13105440005454403723Rat
1359620Tnfsf12TNF superfamily member 12105440387054413213Rat
41046939Rpl13-ps19ribosomal protein L13, pseudogene 19105444330154452286Rat
1587326Polr2aRNA polymerase II subunit A105445243854478486Rat
1308025Slc35g3solute carrier family 35, member G3105447879654481543Rat
1307184Zbtb4zinc finger and BTB domain containing 4105448069854501492Rat
2349Chrnb1cholinergic receptor nicotinic beta 1 subunit105450109654516418Rat
620162Fgf11fibroblast growth factor 11105451650854522067Rat
1559450Tmem102transmembrane protein 102105452390154525997Rat
7642598Spem3SPEM family member 3105453208354536318Rat
1565061Spem2SPEM family member 2105453716854539026Rat
1593311Spem1spermatid maturation 1105454145454542755Rat
621118Nlgn2neuroligin 2105454446154557854Rat
1563438Tmem256transmembrane protein 256105455903054560146Rat
1307016Plscr3phospholipid scramblase 3105456655654573240Rat
1310113Tnk1tyrosine kinase, non-receptor, 1105457139654580547Rat
1593310Tmem95transmembrane protein 95105459979954601746Rat
1307125Kctd11potassium channel tetramerization domain containing 11105460257554604738Rat
1305360Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 1105460532354619472Rat
1563007Ppp1r2l1protein phosphatase 1, regulatory (inhibitor) subunit 2 like 1105461986354624720Rat
1308056Neurl4neuralized E3 ubiquitin protein ligase 4105462492354637262Rat
1562746Gps2G protein pathway suppressor 2105463736054640542Rat
1308029Eif5aeukaryotic translation initiation factor 5A105464010454644845Rat
1305068Ybx2Y box binding protein 2105465971954665371Rat
2711Slc2a4solute carrier family 2 member 4105466601554671581Rat
7673189LOC102555366cofilin-1-like105467312254675094Rat
68432Cldn7claudin 7105468968454692177Rat
1303303Elp5elongator acetyltransferase complex subunit 5105469252654704255Rat
1310172Ctdnep1CTD nuclear envelope phosphatase 1105470436754713781Rat
61911GabarapGABA type A receptor-associated protein105471477754718099Rat
1302969Phf23PHD finger protein 23105471866354722784Rat
1309725Dvl2dishevelled segment polarity protein 2105472335654732823Rat
2014Acadvlacyl-CoA dehydrogenase, very long chain105473287554738102Rat
2325436Mir324microRNA 324105473468054734762Rat
68424Dlg4discs large MAGUK scaffold protein 4105474070054769097Rat
2160Asgr1asialoglycoprotein receptor 1105477572754779642Rat
41020996Trnat-agu28transfer RNA threonine (anticodon AGU) 28105478231054782382Rat
11375109Sec61gl5SEC61 translocon subunit gamma like 5105479541354795676Rat
2161Asgr2asialoglycoprotein receptor 2105482140754834624Rat
621158Clec10aC-type lectin domain containing 10A105487624454880439Rat
1359138Slc16a13solute carrier family 16, member 13105492597354937860Rat
1311125Slc16a11solute carrier family 16, member 11105492912954933021Rat
1563179Bcl6bBCL6B, transcription repressor105494090854947022Rat
41381824LOC120095129uncharacterized LOC120095129105494413354945385Rat
2325364Mir497microRNA 497105495151454951582Rat
2325346Mir195microRNA 195105495183854951924Rat
1308134Bacc1BPTF associated chromatin complex component 1105495199154954756Rat
1305687Rnasekribonuclease K105495490454956622Rat
1311159Alox12arachidonate 12-lipoxygenase, 12S type105495826354970542Rat
1307642Alox12earachidonate 12-lipoxygenase, epidermal105503439255041857Rat
70493Alox15arachidonate 15-lipoxygenase105506016955068885Rat
1306320Pelp1proline, glutamate and leucine rich protein 1105509479855111833Rat
2157Arrb2arrestin, beta 2105514688755154854Rat
1563202Med11mediator complex subunit 11105516432255165940Rat
1562928Cxcl16C-X-C motif chemokine ligand 16105516672155171316Rat
1309845Zmynd15zinc finger, MYND-type containing 15105517119855177812Rat
1308709Tm4sf5transmembrane 4 L six family member 5105521938455225742Rat
1559861Vmo1vitelline membrane outer layer 1 homolog105522794455234794Rat
1560459Gltpd2glycolipid transfer protein domain containing 2105523356355236125Rat
61881Psmb6proteasome 20S subunit beta 6105523925655241586Rat
2319497Tomm7-ps4translocase of outer mitochondrial membrane 7, pseudogene 4105524649955253279Rat
3350Pld2phospholipase D2105525632655274192Rat
1359135Mink1misshapen-like kinase 1105527829355330782Rat
2353Chrnecholinergic receptor nicotinic epsilon subunit105533121155339923Rat
1597577C10h17orf107similar to human chromosome 17 open reading frame 107105533206755333199Rat
1593301Rpl36al-ps2ribosomal protein L36A, pseudogene 2105534345755343858Rat
1310239Gp1baglycoprotein Ib platelet subunit alpha105535293855355804Rat
708476Slc25a11solute carrier family 25 member 11105535759055360441Rat
1305972Rnf167ring finger protein 167105536060355364927Rat
621825Pfn1profilin 1105536526355367968Rat
2555Eno3enolase 3105537053155375921Rat
1305473Spag7sperm associated antigen 7105537724955383404Rat
1311296Camta2calmodulin binding transcription activator 2105538345055401838Rat
1306656Inca1inhibitor of CDK, cyclin A1 interacting protein 1105540198955414364Rat
41216276LOC120095492small nucleolar RNA U3105541149055411704Rat
70928Kif1ckinesin family member 1C105541441255444587Rat
40946213LOC120095361U6 spliceosomal RNA105542206955422172Rat
40938096LOC120095132uncharacterized LOC120095132105545827555464324Rat
1565881Zfp3zinc finger protein 3105547842455486686Rat
1593299ScimpSLP adaptor and CSK interacting membrane protein105550764655527764Rat
41130072LOC120095133uncharacterized LOC120095133105554279555563841Rat
708568Rabep1rabaptin, RAB GTPase binding effector protein 1105556615655667595Rat
41287325Trnas-aga18transfer RNA serine (anticodon AGA) 18105557552155575593Rat
620182Nup88nucleoporin 88105566790355692249Rat
1308492RpainRPA interacting protein105569241055699910Rat
2230C1qbpcomplement C1q binding protein105569995455704605Rat
1307239Dhx33DEAH-box helicase 33105570810255724618Rat
6496100Derl2derlin 2105572776455739442Rat
1564837Mis12MIS12 kinetochore complex component105573974155747915Rat
11405522LOC108352102chromobox protein homolog 3 pseudogene105575111555753851Rat
15932976330403K07RiklRIKEN cDNA 6330403K07 gene like105575561155757162Rat
1310963Nlrp1aNLR family, pyrin domain containing 1A105577856055833639Rat
1593294Nlrp1bNLR family, pyrin domain containing 1B105583838155904374Rat
1310602Ankrd40-ps2ankyrin repeat domain 40, pseudogene 2105591658255917772Rat
41251551LOC120095447small nucleolar RNA SNORA17105591912355919254Rat
7614296LOC102547395uncharacterized LOC102547395105633737456348553Rat
7701476LOC102547579uncharacterized LOC102547579105635448856384414Rat
1308212Wscd1WSC domain containing 1105638585856426442Rat
41277263LOC120095135uncharacterized LOC120095135105643903856459676Rat
41229016LOC120095327uncharacterized LOC120095327105645983556462713Rat
41173355LOC120095446small nucleolar RNA SNORA17105648235456482485Rat
7650893LOC102547851uncharacterized LOC102547851105655855556622104Rat
70906Aipl1aryl hydrocarbon receptor-interacting protein-like 1105665569356664922Rat
1308747PimregPICALM interacting mitotic regulator105666960356674540Rat
1308200Pitpnm3PITPNM family member 3105667469756766552Rat
13047284933427D14RiklRIKEN cDNA 4933427D14 gene like105678386956832668Rat
1308868Txndc17thioredoxin domain containing 17105683274956835721Rat
1309457Med31mediator complex subunit 31105683694456840326Rat
6486589C10h17orf100similar to human chromosome 17 open reading frame 100105684045156843674Rat
631374Slc13a5solute carrier family 13 member 5105686624956891189Rat
7676861LOC102548703probable serine/threonine-protein kinase drkD-like105690698356930190Rat
1585988Xaf1XIAP associated factor 1105691737856929791Rat
1311464Fbxo39F-box protein 39105692969956934911Rat
619913Tekt1tektin 1105695216456980572Rat
1585960Smtnl2smoothelin-like 2105700832257029505Rat
1303335Ggt6gamma-glutamyl transferase 6105705197757054900Rat
62062Mybbp1aMYB binding protein 1a105705689757067258Rat
2303312Spns2SPNS lysolipid transporter 2, sphingosine-1-phosphate105706734857105969Rat
1561884Spns3SPNS lysolipid transporter 3, sphingosine-1-phosphate105711424757169056Rat
620392Ube2g1ubiquitin-conjugating enzyme E2G 1105722596357306748Rat
7553451Rpl17-ps5ribosomal protein L17, pseudogene 5105729452957295230Rat
1309598Ankfy1ankyrin repeat and FYVE domain containing 1105731224657383964Rat
1359124Cyb5d2cytochrome b5 domain containing 2105739426857413336Rat
1311189Zzef1zinc finger ZZ-type and EF-hand domain containing 1105741326557550888Rat
7699687Rps27-ps2ribosomal protein S27, pseudogene 2105743998557440286Rat
41344211LOC120095437small nucleolar RNA SNORA48105746106957461206Rat
41352437LOC120095418U1 spliceosomal RNA105749985457500017Rat
41131756Trnap-ggg6transfer RNA proline (anticodon GGG) 6105751059057510670Rat
2175Atp2a3ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3105758174257612758Rat
3240P2rx1purinergic receptor P2X 1105761858657633648Rat
62023Camkk1calcium/calmodulin-dependent protein kinase kinase 1105763733557660498Rat
1308139Ncbp3nuclear cap binding subunit 3105766571657695432Rat
621644Itgaeintegrin subunit alpha E105770481357764093Rat
1596276Haspinhistone H3 associated protein kinase105774773157750518Rat
11486590LOC108352105uncharacterized LOC108352105105777415057777690Rat
620256P2rx5purinergic receptor P2X 5105777773757789426Rat
1309231Emc6ER membrane protein complex subunit 6105779407257795671Rat
1308924Tax1bp3Tax1 binding protein 3105779584557800363Rat
1308466Ctnscystinosin, lysosomal cystine transporter105780155157817213Rat
1308004Shpksedoheptulokinase105781755157841981Rat
628841Trpv1transient receptor potential cation channel, subfamily V, member 1105785142857876513Rat
1564531Trpv3transient receptor potential cation channel, subfamily V, member 3105788354657915865Rat
621693Aspaaspartoacylase105789170457945267Rat
1565378Spata22spermatogenesis associated 22105794527257963081Rat
1333989Or1e1olfactory receptor family 1 subfamily E member 1105797551957976463Rat
1334228Or1e1colfactory receptor family 1 subfamily E member 1C105798641757987370Rat
9229044LOC103693362uncharacterized LOC103693362105800050358011699Rat
1334190Or1e18olfactory receptor family 1 subfamily E member 18105800925258010196Rat
2323480Ly6e-ps1lymphocyte antigen 6 family member E, pseudogene 1105801110558011735Rat
1359186Olr1469olfactory receptor Olr1469105802506658026010Rat
1333590Or1e16dolfactory receptor family 1 subfamily E member 16D105803624258037186Rat
1332981Olr1471olfactory receptor 1471105805734558058286Rat
1334083Or1e21olfactory receptor family 1 subfamily E member 21105806991058070845Rat
1334012Olr1473-psolfactory receptor pseudogene 1473105810135358102121Rat
1332851Or1e20bolfactory receptor family 1 subfamily E member 20B105815180858152746Rat
1332756Or1e22olfactory receptor family 1 subfamily E member 22105817700158177939Rat
1333378Or1e19b-ps1olfactory receptor family 1 subfamily E member 19, pseudogene 1105819600958196513Rat
1333017Or1e21bolfactory receptor family 1 subfamily E member 21B105821468758215622Rat
1332858Or1e20-ps1olfactory receptor family 1 subfamily E member 20, pseudogene 1105822292158223861Rat
1333952Olr1481olfactory receptor 1481105823788658238830Rat
1333012Or1e16olfactory receptor family 1 subfamily E member 16105827403958274983Rat
2323127Ly6e-ps2lymphocyte antigen 6 family member E, pseudogene 2105828770758288311Rat
1333296Or1e18b-ps1olfactory receptor family 1 subfamily E member 18, pseudogene 1105828917358290117Rat
1333474Olr1484-psolfactory receptor pseudogene 1484105830532158305401Rat
1333644Or1e23olfactory receptor family 1 subfamily E member 23105830532158315807Rat
1333088Or1e26bolfactory receptor family 1 subfamily E member 26B105834934858350286Rat
1334004Olr1477-psolfactory receptor pseudogene 1477105836833958369460Rat
1332828Or1e26-ps1olfactory receptor family 1 subfamily E member 26, pseudogene 1105839491058395850Rat
1333517Or1e27olfactory receptor family 1 subfamily E member 27105840634458407282Rat
1332668Olr1489-psolfactory receptor pseudogene 1489105842187558422035Rat
1333612Or1e27bolfactory receptor family 1 subfamily E member 27B105843438958435327Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
10195D10Wox14158105477580754775965Ratregion
10196D10Mgh22270105477574554776015Ratregion
10664D10Uwm1158105467188954672047Ratregion
34320D10Mgh7237105409867454098889Ratregion
11288D10Wox1295105433337554333470Ratregion
11479D10Mit8185105379738553797494Ratregion
36087D10Rat156170105480929254809463Ratregion
36233D10Rat60161105505021355050374Ratregion
37564D10Rat77202105477429154774503Ratregion
36842DXRat1224105516225055162474Ratregion
36713D10Rat61259105481004554810306Ratregion
39588D1Rat297247105645849456458731Ratregion
39762D10Rat160205105678659656786787Ratregion
41943D10Arb6222105477579154776014Ratregion
41945D10Arb7290105379725053797551Ratregion
41947D10Arb8236105433337654333620Ratregion
42923D10Rat241238105770518957705411Ratregion
41092D10Rat158200105587313655873336Ratregion
1303357D10Got165141105554920155549342Ratregion
1303359D10Got166234105844562058445852Ratregion
66490D10Mco60259105709616957096392Ratregion
1630720D10Got240204105665179656652002Ratregion
1630760D10Wox40152105467185154672003Ratregion
1631253D10Wox42181105527369655273877Ratregion
1632328D10Got235147105667916656679313Ratregion
1632419D10Got233148105693451156934659Ratregion
1578974D10Chm62200105792586457926093Ratregion
1627580D10M11Mit22387105633937956339466Ratregion
1641292D10Got414200105632532056325520Ratregion
1641744D10Wox3987105467318154673268Ratregion
1633363D10Got214120105496930154969421Ratregion
1640581D10Got409178105718296457183138Ratregion
1637431D10M11Mit224131105451425854514389Ratregion
1637892D10Got236138105786391957864057Ratregion
1638078D10Got210231105801050258010733Ratregion
1638078D10Got210231105828865758288866Ratregion
1634094D10Got247251105598916055989413Ratregion
1634752D10Wox41308105527333855273646Ratregion
7193134Efnb3563105427714354277706Ratregion
7193015Efnb30105427663654277325Ratregion
5038740RH127305211105495503554955246Ratregion
7206410mMECIR544608105434594854346556Ratregion
7206548UniSTS:5470341463105535784955359312Ratregion
7206566UniSTS:5470750105466620454667679Ratregion
5031290PMC126639P1176105785541057855586Ratregion
7206182Dvl21487105473114154732628Ratregion
7206202Ybx21344105466384254665188Ratregion
5034053RH141184218105506054155060759Ratregion
5034227RH141847216105750747757507693Ratregion
5026324RH131773184105566736555667549Ratregion
5031966AU046536188105472739454727582Ratregion
5026792RH133546197105537544055375876Ratregion
5027066D17S2042211105730835657308567Ratregion
5027425AI50595383105463989754639980Ratregion
5032743RH135138206105544377455443980Ratregion
5027427AI84833292105667501756675109Ratregion
5028139D11Mit364112105685863456858746Ratregion
5025706RH129345184105509481655095286Ratregion
5028334STS-N93513226105437068854370914Ratregion
5033779RH140090216105567141655671632Ratregion
5025778RH129630203105516672455166927Ratregion
5049928RH133762210105566800055668811Ratregion
5050394RH134031215105537728255377495Ratregion
5049888RH133740203105665573456655937Ratregion
5052553X0087678105431136354311441Ratregion
5052609RH1259230105464012654640356Ratregion
5051503AV32860897105536477955364876Ratregion
5050980RH134369194105776381957764013Ratregion
5041600RH128950162105439078454390946Ratregion
5045926RH131458193105763270157632894Ratregion
5046220RH131627188105472254554722733Ratregion
5048812RH133119208105411044254110650Ratregion
5045356RH131131195105382394953824144Ratregion
5049154RH133316189105738368257383871Ratregion
5046672RH131888188105566525655665444Ratregion
5048070RH132691186105540201555402201Ratregion
5046964RH132056197105572785455728051Ratregion
5049684RH133622219105667411256674331Ratregion
5042550RH129502207105411950154119708Ratregion
5042070RH129221169105569995755700126Ratregion
5040300RH128204216105431106654311282Ratregion
5039902RH127973205105787614557876350Ratregion
5042544RH129498187105570003755700224Ratregion
5039982RH128020217105570016155700560Ratregion
7192241D10Wox3988105467318154673269Ratregion
5041502RH128893187105667487656675063Ratregion
5074394RH137992211105574877255748983Ratregion
5076146RH139006161105570688155707042Ratregion
5077318RH139687198105787958257879780Ratregion
5076254RH139069175105567285055673025Ratregion
5080064RH141362216105570595855706174Ratregion
5080186RH141434183105493426654934449Ratregion
5073042RH137201205105780158257801787Ratregion
5078886RH140608210105409956854099778Ratregion
5073518RH137482181105670885856709039Ratregion
5073578RH137517120105535776955357889Ratregion
5073704RH137590191105548635155486542Ratregion
5070684RH134645220105784173657841956Ratregion
5073410RH137420206105683704056837246Ratregion
5072012RH135414184105660359956603783Ratregion
5071636RH135197218105574687555747093Ratregion
5071834RH135311195105721091057211105Ratregion
5063418BE107661156105746098157461137Ratregion
5066260PMC126639P2300105506089455061193Ratregion
5066356PMC16295P1262105787615657876418Ratregion
5066568AU048280188105516087655161064Ratregion
5088102Slc2a4131105466618454666315Ratregion
5089625AU049266133105634772556347858Ratregion
5087737Cfl1874105467530054676175Ratregion
5090233AU049629282105602237856022660Ratregion
5503252UniSTS:237527210105774834357748553Ratregion
5504089Fgf11471105451864754519118Ratregion
5503617UniSTS:4653811623105469037154691994Ratregion
5504628PMC316663P6113105430861154308724Ratregion
5504634PMC316856P2166105430844854308614Ratregion
5504696PMC56944P1667105446790154468568Ratregion
5505122Chd3802105406374454064546Ratregion
5504528PMC27130P2236105438261654382852Ratregion
5506197UniSTS:498767108105433552054335782Ratregion
5507067UniSTS:224312113105471765354717766Ratregion
5507079UniSTS:224404144105475026554750409Ratregion
5499685G73120149105683891456839336Ratregion
5500282D17S178385105454350554543590Ratregion
5500220AI42767998105705457857054676Ratregion
5500621RH136313187105706696457067151Ratregion
5500326GDB:19007675105430881454309200Ratregion
5500651RH136477195105536461555364810Ratregion
5503488DVL2__3968849105473192354732772Ratregion
5500887G09516148105532024555320393Ratregion
5501103PMC136595P10105438205754382917Ratregion
5501718Efnb3924105427488454275808Ratregion
5505394Hes7784105382719253827976Ratregion
5505738UniSTS:4919891068105455901554560083Ratregion
152025222rs1072766510105640910856409108Ratregion
Position Markers

Flank 1: (D10Mit8)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21053,797,385 - 53,797,494 (+)MAPPER
Rnor_6.01055,678,976 - 55,679,084NCBI
Rnor_5.01055,422,036 - 55,422,144UniSTS
RGSC_v3.41055,851,702 - 55,851,811RGD
RGSC_v3.41055,851,703 - 55,851,811UniSTS
RGSC_v3.11055,865,325 - 55,865,434RGD
Celera1052,962,925 - 52,963,033UniSTS
SHRSP x BN Map1046.5699RGD
SHRSP x BN Map1046.5699UniSTS
Cytogenetic Map10q24UniSTS
Peak: (D10Got165)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21055,549,201 - 55,549,342 (+)MAPPER
Rnor_6.01057,457,227 - 57,457,367NCBI
Rnor_5.01057,203,327 - 57,203,467UniSTS
Rnor_5.01057,203,326 - 57,203,467NCBI
RGSC_v3.41057,729,579 - 57,729,719UniSTS
Celera1054,695,357 - 54,695,488UniSTS
Cytogenetic Map10 RGD
Flank 2: (D10Got166)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21058,445,620 - 58,445,852 (+)MAPPER
Rnor_6.01060,404,560 - 60,404,791NCBI
Rnor_5.01060,141,682 - 60,141,913UniSTS
Rnor_5.01060,141,681 - 60,141,913NCBI
RGSC_v3.41060,865,049 - 60,865,280UniSTS
Celera1057,509,496 - 57,509,727UniSTS
Cytogenetic Map10q24UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105220003059378278Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105379738558445852Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)105527369660677262Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
631652Bp106Blood pressure QTL 106arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105432493354332939Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat


Additional Information

Database Acc Id Source(s)
NCBI Gene Eae18a


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-04-14 Eae18a  Experimental allergic encephalomyelitis QTL 18a  Eae19  Experimental allergic encephalomyelitis QTL 19  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
qtl_cross_type Intercross  
qtl_disease syntenic region on human chromosome 17p13 displays linkage to multiple sclerosis 1302437
qtl_statistics_details Values for incidence, cumulative score, duration and onset were also statistically significant (LOD >= 5.8, p<=0.05).