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Gene: Alox12b (arachidonate 12-lipoxygenase, 12R type) Rattus norvegicus
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Symbol: Alox12b
Name: arachidonate 12-lipoxygenase, 12R type
RGD ID: 1305330
Description: Predicted to have arachidonate 12(S)-lipoxygenase activity; arachidonate 8(R)-lipoxygenase activity; and linoleate 9S-lipoxygenase activity. Involved in arachidonic acid metabolic process and hepoxilin biosynthetic process. Predicted to localize to perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 2. Orthologous to human ALOX12B (arachidonate 12-lipoxygenase, 12R type); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 1,2-dimethylhydrazine (ortholog); 2-hydroxypropanoic acid (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 12R-lipoxygenase; 12R-LOX; arachidonate 12-lipoxygenase, 12R-type; epidermis-type lipoxygenase 12; LOC287425
Orthologs:
Homo sapiens (human) : ALOX12B (arachidonate 12-lipoxygenase, 12R type)  HGNC  Alliance
Mus musculus (house mouse) : Alox12b (arachidonate 12-lipoxygenase, 12R type)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alox12b (arachidonate 12-lipoxygenase, 12R type)
Pan paniscus (bonobo/pygmy chimpanzee) : ALOX12B (arachidonate 12-lipoxygenase, 12R type)
Canis lupus familiaris (dog) : ALOX12B (arachidonate 12-lipoxygenase, 12R type)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alox12b (arachidonate 12-lipoxygenase, 12R type)
Sus scrofa (pig) : ALOX12B (arachidonate 12-lipoxygenase, 12R type)
Chlorocebus sabaeus (African green monkey) : ALOX12B (arachidonate 12-lipoxygenase, 12R type)
Heterocephalus glaber (naked mole-rat) : Alox12b (arachidonate 12-lipoxygenase, 12R type)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01055,744,646 - 55,756,524 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1055,744,588 - 55,756,566 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,487,702 - 55,499,580 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41055,917,373 - 55,926,321 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11055,931,086 - 55,939,956 (+)NCBI
Celera1053,028,472 - 53,040,383 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Alox12b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1305330
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.