Gene: Alox12b (arachidonate 12-lipoxygenase, 12R type) Rattus norvegicus
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Symbol: Alox12b
Name: arachidonate 12-lipoxygenase, 12R type
Description: ENCODES a protein that exhibits arachidonate 12-lipoxygenase activity (ortholog); linoleate 9S-lipoxygenase activity (ortholog); oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (ortholog); INVOLVED IN arachidonic acid metabolic process; hepoxilin biosynthetic process; ceramide biosynthetic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH autosomal recessive congenital ichthyosis (ortholog); autosomal recessive congenital ichthyosis 1 (ortholog); autosomal recessive congenital ichthyosis 2 (ortholog); FOUND IN cytoplasm (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine (ortholog); 3-isobutyl-1-methyl-7H-xanthine (ortholog); aflatoxin B1 (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 12R-lipoxygenase; 12R-LOX; arachidonate 12-lipoxygenase, 12R-type; epidermis-type lipoxygenase 12; LOC287425
Orthologs:
Homo sapiens (human) : ALOX12B (arachidonate 12-lipoxygenase, 12R type)  HGNC  Alliance
Mus musculus (house mouse) : Alox12b (arachidonate 12-lipoxygenase, 12R type)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alox12b (arachidonate 12-lipoxygenase, 12R type)
Pan paniscus (bonobo/pygmy chimpanzee) : ALOX12B (arachidonate 12-lipoxygenase, 12R type)
Canis lupus familiaris (dog) : ALOX12B (arachidonate 12-lipoxygenase, 12R type)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alox12b (arachidonate 12-lipoxygenase, 12R type)
Sus scrofa (pig) : ALOX12B (arachidonate 12-lipoxygenase, 12R type)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01055,744,646 - 55,756,524 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01055,487,702 - 55,499,580 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41055,917,373 - 55,926,321 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11055,931,086 - 55,939,956 (+)NCBI
Celera1053,028,472 - 53,040,383 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Alox12b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1305330
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-01-30
Status: ACTIVE