Kdm6b (lysine demethylase 6B) - Rat Genome Database

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Gene: Kdm6b (lysine demethylase 6B) Rattus norvegicus
Analyze
Symbol: Kdm6b
Name: lysine demethylase 6B
RGD ID: 1307629
Description: Enables chromatin binding activity. Involved in several processes, including hippocampus development; response to activity; and response to fungicide. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex. Human ortholog(s) of this gene implicated in Stolerman neurodevelopmental syndrome. Orthologous to human KDM6B (lysine demethylase 6B); PARTICIPATES IN histone modification pathway; INTERACTS WITH 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Jmjd3; jumonji domain containing 3; jumonji domain-containing 3; LOC363630; lysine (K)-specific demethylase 6B; lysine-specific demethylase 6B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,619,520 - 54,641,014 (-)NCBIGRCr8
mRatBN7.21054,120,716 - 54,142,212 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,121,848 - 54,130,794 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,782,470 - 58,803,961 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,271,086 - 58,292,578 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,779,180 - 53,800,683 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,000,494 - 56,009,582 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,001,799 - 56,008,885 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,743,701 - 55,751,368 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,194,131 - 56,202,139 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,207,737 - 56,221,527 (-)NCBI
Celera1053,278,345 - 53,286,159 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Kdm6bRatbreast carcinoma  ISORGD:13169349587818mRNA:increased expression:breast (human)RGD 
Kdm6bRatneurofibroma  ISORGD:13169359587842mRNA, protein:increased expression:sciatic nerve (mouse)RGD 
Kdm6bRatrenal cell carcinoma  ISORGD:13169349587837mRNA, protein:increased expression:kidney (human)RGD 
Kdm6bRatSpinal Cord Injuries  IEP 9587821mRNA:increased expression:spinal cord (rat)RGD 
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Kdm6bRatcommon variable immunodeficiency  ISORGD:13169348554872ClinVar Annotator: match by term: Common variable immunodeficiencyClinVarPMID:28492532
Kdm6bRatDevelopmental Disease  ISORGD:13169348554872ClinVar Annotator: match by term: Developmental disorderClinVarPMID:25741868
Kdm6bRatDiamond-Blackfan anemia  ISORGD:13169348554872ClinVar Annotator: match by term: Diamond-Blackfan anemiaClinVarPMID:20522432|PMID:21056402|PMID:22267198|PMID:22387016|PMID:23172776|PMID:28492532
Kdm6bRatdyskeratosis congenita  ISORGD:13169348554872ClinVar Annotator: match by term: Dyskeratosis congenitaClinVarPMID:20522432|PMID:21056402|PMID:22267198|PMID:22387016|PMID:23172776|PMID:28492532
Kdm6bRatgenetic disease  ISORGD:13169348554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868|PMID:28492532|PMID:29220567
Kdm6bRatintellectual disability  ISORGD:13169348554872ClinVar Annotator: match by term: Intellectual disabilityClinVarPMID:25741868
Kdm6bRatLi-Fraumeni syndrome  ISORGD:13169348554872ClinVar Annotator: match by term: Li-Fraumeni syndromeClinVarPMID:20522432|PMID:21056402|PMID:22267198|PMID:22387016|PMID:23172776|PMID:26681312|PMID:28369373|PMID:28492532
Kdm6bRatNeurodevelopmental Disorders  ISORGD:13169348554872ClinVar Annotator: match by term: Neurodevelopmental abnormalityClinVar 
Kdm6bRatStolerman neurodevelopmental syndrome  ISORGD:13169348554872ClinVar Annotator: match by term: KDM6B-related condition | ClinVar Annotator: match by term: Neurodevelopmental disorder more ...ClinVarPMID:25741868|PMID:28492532|PMID:31124279|PMID:37196654|PMID:39825153
Kdm6bRatvery long chain acyl-CoA dehydrogenase deficiency  ISORGD:13169348554872ClinVar Annotator: match by term: Very long chain acyl-CoA dehydrogenase deficiencyClinVarPMID:11590124|PMID:28492532|PMID:9973285
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Original Reference(s)
Kdm6bRatadenoid cystic carcinoma  ISORGD:131693411554173CTD Direct Evidence: marker/mechanismCTDPMID:23685749
Kdm6bRatintellectual disability  ISORGD:131693411554173CTD Direct Evidence: marker/mechanismCTDPMID:21937992
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Original Reference(s)
Kdm6bRatStolerman neurodevelopmental syndrome  ISORGD:13169347240710 OMIM 

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Original Reference(s)
Kdm6bRat1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactionsISORGD:13169356480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Kdm6bRat1,2-dimethylhydrazine increases expressionISORGD:131693564804641,2-Dimethylhydrazine results in increased expression of KDM6B mRNACTDPMID:22206623
Kdm6bRat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of KDM6B mRNACTDPMID:32145629
Kdm6bRat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISORGD:13169356480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Kdm6bRat2,2',5,5'-tetrachlorobiphenyl decreases expressionEXP 64804642,5,2',5'-tetrachlorobiphenyl results in decreased expression of KDM6B mRNACTDPMID:23829299
Kdm6bRat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISORGD:13169356480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Kdm6bRat2,2'-Methylenebis(4-methyl-6-tert-butylphenol) multiple interactionsISORGD:13169346480464[CYP3A4 protein affects the susceptibility to 2,2'-methylenebis(4-methyl-6-tert-butylphenol)] which affects the expression of KDM6B mRNACTDPMID:38160208
Kdm6bRat2,3',4,4',5-Pentachlorobiphenyl decreases expressionISORGD:131693564804642,3',4,4',5-pentachlorobiphenyl results in decreased expression of KDM6B mRNACTDPMID:31388691
Kdm6bRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:13169356480464Tetrachlorodibenzodioxin affects the expression of KDM6B mRNACTDPMID:21570461
Kdm6bRat2,4,4'-trichlorobiphenyl multiple interactionsISORGD:13169356480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Kdm6bRat2,4-dinitrotoluene affects expressionEXP 64804642,4-dinitrotoluene affects the expression of KDM6B mRNACTDPMID:21346803
Kdm6bRat2,6-dinitrotoluene affects expressionEXP 64804642,6-dinitrotoluene affects the expression of KDM6B mRNACTDPMID:21346803
Kdm6bRat3,3',5,5'-tetrabromobisphenol A decreases expressionISORGD:13169346480464tetrabromobisphenol A results in decreased expression of KDM6B mRNACTDPMID:33476716
Kdm6bRat4,4'-sulfonyldiphenol decreases expressionISORGD:13169356480464bisphenol S results in decreased expression of KDM6B mRNACTDPMID:39298647
Kdm6bRat4,4'-sulfonyldiphenol affects methylationISORGD:13169356480464bisphenol S affects the methylation of KDM6B geneCTDPMID:31683443
Kdm6bRat4-amino-2,6-dinitrotoluene affects expressionEXP 64804644-amino-2,6-dinitrotoluene affects the expression of KDM6B mRNACTDPMID:21346803
Kdm6bRat4-hydroxynon-2-enal decreases expressionISORGD:131693564804644-hydroxy-2-nonenal results in decreased expression of KDM6B mRNACTDPMID:19191707
Kdm6bRat4-hydroxyphenyl retinamide increases expressionISORGD:13169356480464Fenretinide results in increased expression of KDM6B mRNACTDPMID:28973697
Kdm6bRat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of KDM6B mRNACTDPMID:24780913|PMID:25825206|PMID:30047161|PMID:33150595
Kdm6bRat6-propyl-2-thiouracil increases methylationEXP 6480464Propylthiouracil results in increased methylation of KDM6B promoterCTDPMID:33150595

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Biological Process
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Original Reference(s)
Kdm6bRatcardiac muscle cell differentiation involved_inISORGD:13169351624291 PMID:23856522RGDPMID:23856522
Kdm6bRatcardiac muscle cell differentiation involved_inIEAUniProtKB:Q5NCY0|ensembl:ENSMUSP000000916201600115GO_REF:0000107EnsemblGO_REF:0000107
Kdm6bRatcell fate commitment acts_upstream_of_or_withinISORGD:13169351624291 PMID:18716661RGDPMID:18716661
Kdm6bRatcell fate commitment acts_upstream_of_or_withinIEAUniProtKB:Q5NCY0|ensembl:ENSMUSP000000916201600115GO_REF:0000107EnsemblGO_REF:0000107
Kdm6bRatcellular response to hydrogen peroxide acts_upstream_of_or_withinISORGD:13169351624291 PMID:20808772RGDPMID:20808772
Kdm6bRatcellular response to hydrogen peroxide acts_upstream_of_or_withinIEAUniProtKB:Q5NCY0|ensembl:ENSMUSP000000916201600115GO_REF:0000107EnsemblGO_REF:0000107
Kdm6bRatchromatin organization involved_inIEAUniProtKB-KW:KW-01561600115GO_REF:0000043UniProtGO_REF:0000043
Kdm6bRatchromatin remodeling involved_inIEAUniProtKB:Q5NCY0|ensembl:ENSMUSP000000916201600115GO_REF:0000107EnsemblGO_REF:0000107
Kdm6bRatchromatin remodeling involved_inISORGD:13169351624291 PMID:21095589RGDPMID:21095589
Kdm6bRatendothelial cell differentiation involved_inISORGD:13169351624291 PMID:23856522RGDPMID:23856522
Kdm6bRatendothelial cell differentiation involved_inIEAUniProtKB:Q5NCY0|ensembl:ENSMUSP000000916201600115GO_REF:0000107EnsemblGO_REF:0000107
Kdm6bRatheart development involved_inIBAMGI:1095419|MGI:2448492|MGI:894810|PANTHER:PTN002304105|UniProtKB:A0A8M2BG42|ZFIN:ZDB-GENE-040724-166|ZFIN:ZDB-GENE-091005-11600115GO_REF:0000033GO_CentralGO_REF:0000033
Kdm6bRathippocampus development  IDA 9587811 RGD 
Kdm6bRatinflammatory response to antigenic stimulus  IEP 9587822ovalbuminRGD 
Kdm6bRatmesodermal cell differentiation involved_inISORGD:13169351624291 PMID:23856522RGDPMID:23856522
Kdm6bRatmesodermal cell differentiation involved_inIEAUniProtKB:Q5NCY0|ensembl:ENSMUSP000000916201600115GO_REF:0000107EnsemblGO_REF:0000107
Kdm6bRatpositive regulation of cold-induced thermogenesis involved_inISSUniProtKB:Q5NCY013673750PMID:26625958YuBioLab 
Kdm6bRatpositive regulation of cold-induced thermogenesis involved_inIEAUniProtKB:Q5NCY0|ensembl:ENSMUSP000000916201600115GO_REF:0000107EnsemblGO_REF:0000107
Kdm6bRatpositive regulation of cold-induced thermogenesis involved_inISORGD:13169351624291 PMID:26625958RGDPMID:26625958
Kdm6bRatpositive regulation of transcription by RNA polymerase II involved_inISORGD:13169351624291 PMID:23856522RGDPMID:23856522
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Cellular Component

  
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Original Reference(s)
Kdm6bRatMLL3/4 complex part_ofIBAFB:FBgn0260749|PANTHER:PTN001018659|UniProtKB:O15550|WB:WBGene000170461600115GO_REF:0000033GO_CentralGO_REF:0000033
Kdm6bRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Kdm6bRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Kdm6bRatnucleus located_inISORGD:13169351624291 PMID:23856522RGDPMID:23856522
Kdm6bRatnucleus located_inIEAUniProtKB:Q5NCY0|ensembl:ENSMUSP000000916201600115GO_REF:0000107EnsemblGO_REF:0000107

Molecular Function
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Kdm6bRatbeta-catenin binding enablesISORGD:13169351624291UniProtKB:Q02248 PMID:23856522RGDPMID:23856522
Kdm6bRatbeta-catenin binding enablesIEAUniProtKB:Q5NCY0|ensembl:ENSMUSP000000916201600115GO_REF:0000107EnsemblGO_REF:0000107
Kdm6bRatchromatin binding  IDA 9587811 RGD 
Kdm6bRatchromatin DNA binding enablesIBAMGI:1095419|PANTHER:PTN0003611791600115GO_REF:0000033GO_CentralGO_REF:0000033
Kdm6bRatdioxygenase activity enablesIEAUniProtKB-KW:KW-02231600115GO_REF:0000043UniProtGO_REF:0000043
Kdm6bRathistone demethylase activity enablesIEAARBA:ARBA000267041600115GO_REF:0000117UniProtGO_REF:0000117
Kdm6bRathistone H3K27me2/H3K27me3 demethylase activity enablesISORGD:13169341624291 PMID:28262558RGDPMID:28262558
Kdm6bRathistone H3K27me2/H3K27me3 demethylase activity enablesIEAUniProtKB:O15054|ensembl:ENSP000004125131600115GO_REF:0000107EnsemblGO_REF:0000107
Kdm6bRathistone H3K27me2/H3K27me3 demethylase activity enablesIEAUniProtKB:Q5NCY0|ensembl:ENSMUSP000000916201600115GO_REF:0000107EnsemblGO_REF:0000107
Kdm6bRathistone H3K27me2/H3K27me3 demethylase activity enablesISORGD:13169351624291 PMID:17928865, PMID:18716661, PMID:23856522RGDPMID:17928865|PMID:18716661|PMID:23856522
Kdm6bRathistone H3K27me2/H3K27me3 demethylase activity enablesIBAFB:FBgn0260749|MGI:1095419|MGI:2448492|PANTHER:PTN000361193|UniProtKB:O15054|WB:WBGene00017571|ZFIN:ZDB-GENE-040724-1661600115GO_REF:0000033GO_CentralGO_REF:0000033
Kdm6bRatmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Kdm6bRatoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Kdm6bRatprotein binding enablesISORGD:13169341624291UniProtKB:P03372 PMID:21841772RGDPMID:21841772
Kdm6bRatprotein binding enablesISORGD:13169351624291UniProtKB:P97496|UniProtKB:Q3TKT4|UniProtKB:Q6PDG5|UniProtKB:Q9JKD8 PMID:21095589RGDPMID:21095589
Kdm6bRatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIBAMGI:1095419|MGI:894810|PANTHER:PTN0003611791600115GO_REF:0000033GO_CentralGO_REF:0000033
Kdm6bRatsequence-specific DNA binding enablesISORGD:13169351624291 PMID:17928865RGDPMID:17928865
Kdm6bRatsequence-specific DNA binding enablesIEAUniProtKB:Q5NCY0|ensembl:ENSMUSP000000916201600115GO_REF:0000107EnsemblGO_REF:0000107
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RGD Manual Annotations


  
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Original Reference(s)
Kdm6bRathistone modification pathway   ISORGD:13169347242632 RGD 

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#
Reference Title
Reference Citation
1. Coexpression of nuclear receptors and histone methylation modifying genes in the testis: implications for endocrine disruptor modes of action. Anderson AM, etal., PLoS One. 2012;7(4):e34158. doi: 10.1371/journal.pone.0034158. Epub 2012 Apr 4.
2. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Epigenetic induction of the Ink4a/Arf locus prevents Schwann cell overproliferation during nerve regeneration and after tumorigenic challenge. Gomez-Sanchez JA, etal., Brain. 2013 Jul;136(Pt 7):2262-78. doi: 10.1093/brain/awt130. Epub 2013 Jun 6.
5. High-intensity training induces EIB in rats through neuron transdifferentiation of adrenal medulla chromaffin cells. He R, etal., Am J Physiol Lung Cell Mol Physiol. 2013 May 1;304(9):L602-12. doi: 10.1152/ajplung.00406.2012. Epub 2013 Feb 15.
6. Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons. Henriquez B, etal., Mol Cell Neurosci. 2013 Nov;57:130-43. doi: 10.1016/j.mcn.2013.07.012. Epub 2013 Aug 8.
7. Molecular mechanism of Jmjd3-mediated interleukin-6 gene regulation in endothelial cells underlying spinal cord injury. Lee K, etal., J Neurochem. 2012 Jul;122(2):272-82. doi: 10.1111/j.1471-4159.2012.07786.x. Epub 2012 Jun 6.
8. Jmjd3-Mediated H3K27me3 Dynamics Orchestrate Brown Fat Development and Regulate White Fat Plasticity. Pan D, etal., Dev Cell. 2015 Dec 7;35(5):568-583. doi: 10.1016/j.devcel.2015.11.002. Epub 2015 Nov 25.
9. Histone demethylase KDM6B promotes epithelial-mesenchymal transition. Ramadoss S, etal., J Biol Chem. 2012 Dec 28;287(53):44508-17. doi: 10.1074/jbc.M112.424903. Epub 2012 Nov 14.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Expression and significance of histone H3K27 demethylases in renal cell carcinoma. Shen Y, etal., BMC Cancer. 2012 Oct 12;12:470. doi: 10.1186/1471-2407-12-470.
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PMID:17825402   PMID:17928865   PMID:18716661   PMID:19710508   PMID:20808772   PMID:21095589   PMID:23856522   PMID:24097101   PMID:27010597   PMID:27425890   PMID:27815838   PMID:28262558  
PMID:29753027   PMID:29982434   PMID:32084453   PMID:32258110   PMID:33391480   PMID:33456568   PMID:33479437   PMID:34297635   PMID:34948220   PMID:37287407   PMID:37445785   PMID:37653221  



Kdm6b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,619,520 - 54,641,014 (-)NCBIGRCr8
mRatBN7.21054,120,716 - 54,142,212 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,121,848 - 54,130,794 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,782,470 - 58,803,961 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,271,086 - 58,292,578 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,779,180 - 53,800,683 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,000,494 - 56,009,582 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,001,799 - 56,008,885 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,743,701 - 55,751,368 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,194,131 - 56,202,139 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,207,737 - 56,221,527 (-)NCBI
Celera1053,278,345 - 53,286,159 (-)NCBICelera
Cytogenetic Map10q24NCBI
KDM6B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,834,217 - 7,854,796 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,834,217 - 7,854,796 (+)EnsemblGRCh38hg38GRCh38
GRCh37177,737,535 - 7,758,114 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,683,960 - 7,698,843 (+)NCBINCBI36Build 36hg18NCBI36
Celera177,771,102 - 7,785,939 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,637,994 - 7,652,831 (+)NCBIHuRef
CHM1_1177,752,263 - 7,767,093 (+)NCBICHM1_1
T2T-CHM13v2.0177,738,322 - 7,760,122 (+)NCBIT2T-CHM13v2.0
Kdm6b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,289,334 - 69,311,188 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,289,334 - 69,304,501 (-)EnsemblGRCm39 Ensembl
GRCm381169,398,508 - 69,420,367 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,398,508 - 69,413,675 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,212,010 - 69,227,177 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,214,703 - 69,229,870 (-)NCBIMGSCv36mm8
Celera1176,352,998 - 76,368,171 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.6NCBI
Kdm6b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,086,204 - 9,094,404 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,085,239 - 9,106,658 (-)NCBIChiLan1.0ChiLan1.0
KDM6B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,431,013 - 15,452,821 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11717,397,061 - 17,418,850 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,878,783 - 7,889,372 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,858,734 - 7,876,220 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,866,973 - 7,874,937 (+)Ensemblpanpan1.1panPan2
KDM6B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,689,000 - 32,711,026 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,696,211 - 32,710,666 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,827,236 - 32,848,755 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,792,977 - 32,814,492 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,792,975 - 32,814,114 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,760,822 - 32,782,338 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,716,996 - 32,738,518 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,895,969 - 32,917,506 (+)NCBIUU_Cfam_GSD_1.0
Kdm6b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,603,112 - 47,624,715 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365951,089,544 - 1,097,595 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365951,077,318 - 1,099,082 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KDM6B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1253,098,964 - 53,108,214 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11253,087,072 - 53,108,949 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,452,697 - 55,475,051 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KDM6B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,221,769 - 7,241,230 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,232,426 - 7,241,040 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,166,684 - 14,188,438 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kdm6b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,425,816 - 10,433,806 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478610,413,670 - 10,435,118 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Kdm6b
32 total Variants

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:78
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000067677
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 76 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat

1 to 10 of 76 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 30 of 33 rows
RefSeq Transcripts NM_001108829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF532386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF532387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF532388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF532389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF532390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF532391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF532392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF532393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF532394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 33 rows

Ensembl Acc Id: ENSRNOT00000067677   ⟹   ENSRNOP00000060247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,121,848 - 54,130,794 (-)Ensembl
Rnor_6.0 Ensembl1056,001,799 - 56,008,885 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116399   ⟹   ENSRNOP00000091469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,121,848 - 54,130,794 (-)Ensembl
RefSeq Acc Id: NM_001108829   ⟹   NP_001102299
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,619,520 - 54,641,014 (-)NCBI
mRatBN7.21054,120,718 - 54,142,212 (-)NCBI
Rnor_6.01056,001,626 - 56,009,582 (-)NCBI
Rnor_5.01055,743,701 - 55,751,368 (-)NCBI
RGSC_v3.41056,194,131 - 56,202,139 (-)RGD
Celera1053,278,345 - 53,286,159 (-)RGD
Sequence:
RefSeq Acc Id: NM_001401950   ⟹   NP_001388879
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,619,520 - 54,641,014 (-)NCBI
mRatBN7.21054,120,718 - 54,142,212 (-)NCBI
RefSeq Acc Id: XM_039086469   ⟹   XP_038942397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,619,520 - 54,641,004 (-)NCBI
mRatBN7.21054,120,716 - 54,142,212 (-)NCBI
RefSeq Acc Id: XM_039086470   ⟹   XP_038942398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,619,520 - 54,636,888 (-)NCBI
mRatBN7.21054,120,716 - 54,138,075 (-)NCBI
RefSeq Acc Id: XM_039086471   ⟹   XP_038942399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,619,520 - 54,635,670 (-)NCBI
mRatBN7.21054,120,716 - 54,137,352 (-)NCBI
RefSeq Acc Id: XM_039086472   ⟹   XP_038942400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,619,520 - 54,635,603 (-)NCBI
mRatBN7.21054,120,716 - 54,136,810 (-)NCBI
RefSeq Acc Id: XM_039086473   ⟹   XP_038942401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,619,520 - 54,630,626 (-)NCBI
mRatBN7.21054,120,716 - 54,131,830 (-)NCBI
RefSeq Acc Id: XM_039086474   ⟹   XP_038942402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,619,520 - 54,630,984 (-)NCBI
mRatBN7.21054,120,716 - 54,132,184 (-)NCBI
RefSeq Acc Id: XM_039086475   ⟹   XP_038942403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,619,520 - 54,632,186 (-)NCBI
mRatBN7.21054,120,716 - 54,133,392 (-)NCBI
RefSeq Acc Id: XM_039086476   ⟹   XP_038942404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,619,520 - 54,632,186 (-)NCBI
mRatBN7.21054,120,716 - 54,133,392 (-)NCBI
RefSeq Acc Id: XM_039086477   ⟹   XP_038942405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,619,520 - 54,632,618 (-)NCBI
mRatBN7.21054,120,716 - 54,133,824 (-)NCBI
RefSeq Acc Id: XM_039086478   ⟹   XP_038942406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,619,520 - 54,641,004 (-)NCBI
mRatBN7.21054,120,716 - 54,142,212 (-)NCBI
RefSeq Acc Id: XM_039086479   ⟹   XP_038942407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,619,520 - 54,636,888 (-)NCBI
mRatBN7.21054,120,716 - 54,138,075 (-)NCBI
RefSeq Acc Id: XM_039086480   ⟹   XP_038942408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,619,520 - 54,635,665 (-)NCBI
mRatBN7.21054,120,716 - 54,136,863 (-)NCBI
RefSeq Acc Id: XM_039086481   ⟹   XP_038942409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,619,520 - 54,635,603 (-)NCBI
mRatBN7.21054,120,716 - 54,136,810 (-)NCBI
RefSeq Acc Id: XM_039086483   ⟹   XP_038942411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,619,520 - 54,641,004 (-)NCBI
mRatBN7.21054,120,716 - 54,142,212 (-)NCBI
RefSeq Acc Id: XM_063269516   ⟹   XP_063125586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,619,520 - 54,636,932 (-)NCBI
RefSeq Acc Id: XM_063269517   ⟹   XP_063125587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,619,520 - 54,630,984 (-)NCBI
RefSeq Acc Id: XM_063269518   ⟹   XP_063125588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,619,520 - 54,641,004 (-)NCBI
1 to 30 of 35 rows
Protein RefSeqs NP_001102299 (Get FASTA)   NCBI Sequence Viewer  
  NP_001388879 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942397 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942398 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942399 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942400 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942401 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942402 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942403 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942404 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942405 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942406 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942407 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942408 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942409 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942411 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125586 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125587 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125588 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABU49313 (Get FASTA)   NCBI Sequence Viewer  
  ABU49314 (Get FASTA)   NCBI Sequence Viewer  
  ABU49315 (Get FASTA)   NCBI Sequence Viewer  
  ABU49316 (Get FASTA)   NCBI Sequence Viewer  
  ABU49317 (Get FASTA)   NCBI Sequence Viewer  
  ABU49318 (Get FASTA)   NCBI Sequence Viewer  
  ABU49319 (Get FASTA)   NCBI Sequence Viewer  
  ABU49320 (Get FASTA)   NCBI Sequence Viewer  
  ABU49321 (Get FASTA)   NCBI Sequence Viewer  
  ABU49322 (Get FASTA)   NCBI Sequence Viewer  
  ABU49323 (Get FASTA)   NCBI Sequence Viewer  
1 to 30 of 35 rows
1 to 5 of 21 rows
1 to 5 of 21 rows
RefSeq Acc Id: NP_001102299   ⟸   NM_001108829
- Peptide Label: isoform 1
- UniProtKB: A6HFR1 (UniProtKB/TrEMBL),   G3V9U4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060247   ⟸   ENSRNOT00000067677
RefSeq Acc Id: XP_038942406   ⟸   XM_039086478
- Peptide Label: isoform X1
- UniProtKB: A6HFR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942411   ⟸   XM_039086483
- Peptide Label: isoform X3
- UniProtKB: A6HFR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942397   ⟸   XM_039086469
- Peptide Label: isoform X1
- UniProtKB: A6HFR1 (UniProtKB/TrEMBL)
JmjC

Name Modeler Protein Id AA Range Protein Structure
AF-G3V9U4-F1-model_v2 AlphaFold G3V9U4 1-1356 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 35 of 35 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-24550 BioCyc
Ensembl Genes ENSRNOG00000037613 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067677 ENTREZGENE
  ENSRNOT00000067677.4 UniProtKB/TrEMBL
  ENSRNOT00000116399 ENTREZGENE
  ENSRNOT00000116399.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.1370 UniProtKB/TrEMBL
  1.25.40.10 UniProtKB/TrEMBL
  2.10.110.20 UniProtKB/TrEMBL
  Cupin UniProtKB/TrEMBL
InterPro Corepressor-Demethylase UniProtKB/TrEMBL
  JmjC_dom UniProtKB/TrEMBL
  KDM6_GATAL_sf UniProtKB/TrEMBL
  KDM6A_B-like_C-hel UniProtKB/TrEMBL
  KDM6A_B-like_GATAL UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
KEGG Report rno:363630 UniProtKB/TrEMBL
NCBI Gene 363630 ENTREZGENE
PANTHER LYSINE-SPECIFIC DEMETHYLASE UniProtKB/TrEMBL
  PTHR14017:SF5 UniProtKB/TrEMBL
Pfam JmjC UniProtKB/TrEMBL
  KDM6_C-hel UniProtKB/TrEMBL
  KDM6_GATAL UniProtKB/TrEMBL
PhenoGen Kdm6b PhenoGen
PROSITE JMJC UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  TPR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037613 RatGTEx
SMART JmjC UniProtKB/TrEMBL
Superfamily-SCOP Clavaminate synthase-like UniProtKB/TrEMBL
  SSF48452 UniProtKB/TrEMBL
UniProt A0A8I6AFH2 ENTREZGENE, UniProtKB/TrEMBL
  A6HFR1 ENTREZGENE, UniProtKB/TrEMBL
  G3V9U4 ENTREZGENE, UniProtKB/TrEMBL
1 to 35 of 35 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Kdm6b  lysine demethylase 6B  Kdm6b  lysine (K)-specific demethylase 6B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-03-09 Kdm6b  lysine (K)-specific demethylase 6B  Jmjd3  jumonji domain containing 3   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Jmjd3  jumonji domain containing 3   Jmjd3_predicted  jumonji domain containing 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Jmjd3_predicted  jumonji domain containing 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED