Alox12 (arachidonate 12-lipoxygenase, 12S type) - Rat Genome Database

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Gene: Alox12 (arachidonate 12-lipoxygenase, 12S type) Rattus norvegicus
Analyze
Symbol: Alox12
Name: arachidonate 12-lipoxygenase, 12S type
RGD ID: 1311159
Description: Predicted to enable arachidonate 12(S)-lipoxygenase activity; arachidonate 15-lipoxygenase activity; and linoleate 13S-lipoxygenase activity. Involved in several processes, including fatty acid metabolic process; positive regulation of biosynthetic process; and regulation of apoptotic process. Located in sarcolemma. Biomarker of congestive heart failure; hypertension; and obesity. Orthologous to human ALOX12 (arachidonate 12-lipoxygenase, 12S type); PARTICIPATES IN lipoxygenase mediated pathway of arachidonic acid metabolism; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benoxaprofen; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 12-LO; 12S-lipoxygenase; 12S-LOX; arachidonate (12S)-lipoxygenase; arachidonate (15S)-lipoxygenase; arachidonate 12-lipoxygenase; arachidonate 12-lipoxygenase, 12S-type; arachidonate 15-lipoxygenase,15S-type; linoleate 13S-lipoxygenase; lipoxin synthase 12-LO; LOC287454; MGC187960; platelet 12-LOX; platelet-type lipoxygenase 12; polyunsaturated fatty acid lipoxygenase ALOX12
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,456,923 - 55,469,239 (-)NCBIGRCr8
mRatBN7.21054,958,263 - 54,970,542 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,958,271 - 54,970,542 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,637,904 - 59,650,163 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,126,503 - 59,138,762 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,625,627 - 54,637,884 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,851,734 - 56,864,049 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,851,734 - 56,864,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,595,898 - 56,608,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,080,603 - 57,092,874 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11057,095,024 - 57,106,540 (-)NCBI
Celera1054,109,834 - 54,122,106 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
baicalein  (ISO)
benoxaprofen  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP,ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
D-glucose  (ISO)
D-penicillamine  (EXP)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
dithiol  (EXP)
diuron  (EXP)
docebenone  (ISO)
fenofibrate  (ISO)
flavonoids  (EXP)
genistein  (ISO)
glucose  (ISO)
glutathione disulfide  (ISO)
hydroquinone  (ISO)
indometacin  (EXP)
kaempferol  (ISO)
lanthanum trichloride  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP)
masoprocol  (EXP,ISO)
methotrexate  (EXP,ISO)
nickel atom  (ISO)
nicotine  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
perfluorohexanesulfonic acid  (ISO)
picrotoxin  (EXP)
pirinixic acid  (ISO)
polymyxin B2  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
tamoxifen  (ISO)
tetraphene  (ISO)
tioguanine  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
cytosol  (IBA,ISO)
membrane  (ISO,ISS)
sarcolemma  (IBA,IDA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Arachidonic acid cascade in endothelial pathobiology. Bogatcheva NV, etal., Microvasc Res. 2005 May;69(3):107-27.
2. Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. Chakrabarti SK, etal., Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E175-87. Epub 2010 Oct 26.
3. Endogenous 12(S)-HETE production by tumor cells and its role in metastasis. Chen YQ, etal., Cancer Res. 1994 Mar 15;54(6):1574-9.
4. Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer. Gao X, etal., Urology. 1995 Aug;46(2):227-37.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. Gregus AM, etal., FASEB J. 2013 May;27(5):1939-49. doi: 10.1096/fj.12-217414. Epub 2013 Feb 4.
8. Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis. Hussain H, etal., Am J Physiol. 1994 Jan;266(1 Pt 1):C243-53.
9. Genetic expression profiles during physiological and pathological cardiac hypertrophy and heart failure in rats. Kong SW, etal., Physiol Genomics. 2005 Mar 21;21(1):34-42. Epub 2004 Dec 28.
10. An aldosterone-related system in the ventrolateral medulla oblongata of spontaneously hypertensive and Wistar-Kyoto rats. Kumar NN, etal., Clin Exp Pharmacol Physiol. 2006 Jan-Feb;33(1-2):71-5.
11. Inhibition of ovulation by a lipoxygenase inhibitor involves reduced cyclooxygenase-2 expression and prostaglandin E2 production in gonadotropin-primed immature rats. Kurusu S, etal., Reproduction. 2009 Jan;137(1):59-66.
12. Blockade of 12-lipoxygenase expression protects cortical neurons from apoptosis induced by beta-amyloid peptide. Lebeau A, etal., Cell Death Differ. 2004 Aug;11(8):875-84.
13. Vitamin K prevents oxidative cell death by inhibiting activation of 12-lipoxygenase in developing oligodendrocytes. Li J, etal., J Neurosci Res. 2009 Jul;87(9):1997-2005.
14. Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes. Liu Y, etal., Am J Kidney Dis. 2008 Aug;52(2):242-50. Epub 2008 Mar 25.
15. The expression of cyclooxygenases and lipoxygenases in renal ischemia-reperfusion injury. Matsuyama M, etal., Transplant Proc. 2004 Sep;36(7):1939-42.
16. Eicosanoid regulation of angiogenesis: role of endothelial arachidonate 12-lipoxygenase. Nie D, etal., Blood. 2000 Apr 1;95(7):2304-11.
17. Increased metastatic potential in human prostate carcinoma cells by overexpression of arachidonate 12-lipoxygenase. Nie D, etal., Clin Exp Metastasis. 2003;20(7):657-63.
18. The rat leukocyte-type 12-lipoxygenase exhibits an intrinsic hepoxilin A3 synthase activity. Nigam S, etal., J Biol Chem. 2004 Jul 9;279(28):29023-30. Epub 2004 May 3.
19. 12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet. Nunemaker CS, etal., Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1065-75. Epub 2008 Sep 9.
20. Activation of the 12-lipoxygenase and signal transducer and activator of transcription pathway during neointima formation in a model of the metabolic syndrome. Pei H, etal., Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E92-E102. Epub 2005 Aug 23.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
23. Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes. Prasad VV, etal., Neurochem Int. 2008 Dec;53(6-8):220-9. Epub 2008 Jul 16.
24. Role of 12-lipoxygenase in hypoxia-induced rat pulmonary artery smooth muscle cell proliferation. Preston IR, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Feb;290(2):L367-74. Epub 2005 Sep 30.
25. GOA pipeline RGD automated data pipeline
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. A microarray study of gene expression profiles in nasal polyps. Rostkowska-Nadolska B, etal., Auris Nasus Larynx. 2011 Feb;38(1):58-64. Epub 2010 Jun 15.
28. Induction of epithelial arachidonate 12-lipoxygenase at active sites of inflammatory bowel disease. Shannon VR, etal., Am J Physiol. 1993 Jan;264(1 Pt 1):G104-11.
29. Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. Tang DG, etal., Proc Natl Acad Sci U S A. 1996 May 28;93(11):5241-6.
30. Decreased activity of arachidonate 12-lipoxygenase in platelets of Japanese patients with non-insulin-dependent diabetes mellitus. Tohjima T, etal., Metabolism. 1998 Mar;47(3):257-63.
31. 12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes. Wang H, etal., Eur J Neurosci. 2004 Oct;20(8):2049-58.
32. Angiotensin II type 1 receptor expression is increased via 12-lipoxygenase in high glucose-stimulated glomerular cells and type 2 diabetic glomeruli. Xu ZG, etal., Nephrol Dial Transplant. 2009 Jun;24(6):1744-52. Epub 2008 Dec 22.
33. Gene expression profiling of the ageing rat vibrissa follicle. Yang CL, etal., Br J Dermatol. 2005 Jul;153(1):22-8.
34. Arachidonate 12-lipoxygenases. Yoshimoto T and Takahashi Y, Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:245-62.
35. Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor. Yoshimura R, etal., Int J Mol Med. 2004 Jan;13(1):41-6.
36. Relationship between lipoxygenase and human testicular cancer. Yoshimura R, etal., Int J Mol Med. 2004 Mar;13(3):389-93.
37. Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors. Yoshimura R, etal., J Urol. 2003 Nov;170(5):1994-9.
38. Survival effects of cyclooxygenase-2 and 12-lipooxygenase in Egyptian women with operable breast cancer. Zeeneldin AA, etal., Indian J Cancer. 2009 Jan-Mar;46(1):54-60.
39. Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation. Zhang Y, etal., J Neurosci. 2004 Nov 24;24(47):10616-27.
40. Impaired arachidonic acid-mediated dilation of small mesenteric arteries in Zucker diabetic fatty rats. Zhou W, etal., Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2210-8. Epub 2004 Dec 30.
41. Lipoxygenase-dependent superoxide release in skeletal muscle. Zuo L, etal., J Appl Physiol. 2004 Aug;97(2):661-8. Epub 2004 Apr 23.
Additional References at PubMed
PMID:1851637   PMID:2217179   PMID:2377602   PMID:7868854   PMID:8188678   PMID:8250832   PMID:8319693   PMID:8912711   PMID:9501222   PMID:9751607   PMID:10383730   PMID:11256953  
PMID:12477932   PMID:15010818   PMID:15111312   PMID:15161019   PMID:15305153   PMID:16040349   PMID:17493578   PMID:18311922   PMID:19056867   PMID:19095999   PMID:21285403   PMID:22237009  
PMID:22984144   PMID:23504711   PMID:23578768   PMID:24282679   PMID:24816396   PMID:25036362   PMID:25293588   PMID:27021232   PMID:27600103  


Genomics

Comparative Map Data
Alox12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,456,923 - 55,469,239 (-)NCBIGRCr8
mRatBN7.21054,958,263 - 54,970,542 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,958,271 - 54,970,542 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,637,904 - 59,650,163 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,126,503 - 59,138,762 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,625,627 - 54,637,884 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,851,734 - 56,864,049 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,851,734 - 56,864,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,595,898 - 56,608,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,080,603 - 57,092,874 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11057,095,024 - 57,106,540 (-)NCBI
Celera1054,109,834 - 54,122,106 (-)NCBICelera
Cytogenetic Map10q24NCBI
ALOX12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38176,996,049 - 7,010,754 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl176,996,049 - 7,010,754 (+)EnsemblGRCh38hg38GRCh38
GRCh37176,899,368 - 6,914,073 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36176,840,108 - 6,854,779 (+)NCBINCBI36Build 36hg18NCBI36
Build 34176,840,127 - 6,854,776NCBI
Celera176,924,952 - 6,939,560 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef176,793,203 - 6,807,748 (+)NCBIHuRef
CHM1_1176,908,840 - 6,923,485 (+)NCBICHM1_1
T2T-CHM13v2.0176,896,743 - 6,911,368 (+)NCBIT2T-CHM13v2.0
Alox12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,132,283 - 70,146,206 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,132,283 - 70,146,179 (-)EnsemblGRCm39 Ensembl
GRCm381170,241,457 - 70,255,380 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,241,457 - 70,255,353 (-)EnsemblGRCm38mm10GRCm38
MGSCv371170,054,957 - 70,068,843 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,057,650 - 70,071,536 (-)NCBIMGSCv36mm8
Celera1177,785,930 - 77,799,829 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
ALOX12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21914,589,497 - 14,604,366 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11716,555,472 - 16,571,790 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,026,839 - 7,041,598 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,014,038 - 7,029,602 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,014,591 - 7,029,602 (+)Ensemblpanpan1.1panPan2
ALOX12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,026,193 - 32,038,698 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,882,501 - 32,038,119 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,164,885 - 32,176,845 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,131,142 - 32,143,103 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,131,150 - 32,143,103 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,097,211 - 32,109,170 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,056,686 - 32,068,416 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,232,935 - 32,244,895 (+)NCBIUU_Cfam_GSD_1.0
ALOX12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,401,810 - 52,414,903 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,401,861 - 52,414,913 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,724,529 - 54,738,428 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALOX12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,355,795 - 6,370,051 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,356,058 - 6,369,738 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605915,044,892 - 15,059,177 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alox12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,542,970 - 9,555,214 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247869,542,966 - 9,555,235 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Alox12
44 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:188
Count of miRNA genes:138
Interacting mature miRNAs:148
Transcripts:ENSRNOT00000033098
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105220003059378278Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105379738558445852Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat

Markers in Region
D10Got214  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,969,301 - 54,969,421 (+)MAPPERmRatBN7.2
Rnor_6.01056,862,765 - 56,862,884NCBIRnor6.0
Rnor_5.01056,606,929 - 56,607,048UniSTSRnor5.0
RGSC_v3.41057,091,634 - 57,091,753UniSTSRGSC3.4
Celera1054,120,866 - 54,120,985UniSTS
Cytogenetic Map10q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 6 2 3 1
Low 3 43 48 33 13 33 5 5 55 35 28 10 5
Below cutoff 6 6 6 3 5 19 8 3

Sequence


RefSeq Acc Id: ENSRNOT00000033098   ⟹   ENSRNOP00000034009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,958,271 - 54,970,542 (-)Ensembl
Rnor_6.0 Ensembl1056,851,734 - 56,864,005 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091131   ⟹   ENSRNOP00000069214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,960,903 - 54,970,542 (-)Ensembl
Rnor_6.0 Ensembl1056,854,366 - 56,864,005 (-)Ensembl
RefSeq Acc Id: NM_001105798   ⟹   NP_001099268
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,456,928 - 55,469,199 (-)NCBI
mRatBN7.21054,958,271 - 54,970,542 (-)NCBI
Rnor_6.01056,851,734 - 56,864,005 (-)NCBI
Rnor_5.01056,595,898 - 56,608,192 (-)NCBI
RGSC_v3.41057,080,603 - 57,092,874 (-)RGD
Celera1054,109,834 - 54,122,106 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085479   ⟹   XP_038941407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,456,923 - 55,467,191 (-)NCBI
mRatBN7.21054,958,263 - 54,969,681 (-)NCBI
RefSeq Acc Id: XM_039085480   ⟹   XP_038941408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,456,923 - 55,467,022 (-)NCBI
mRatBN7.21054,958,263 - 54,969,678 (-)NCBI
RefSeq Acc Id: XM_063268659   ⟹   XP_063124729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,456,923 - 55,469,239 (-)NCBI
RefSeq Acc Id: XM_063268660   ⟹   XP_063124730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,461,214 - 55,469,233 (-)NCBI
RefSeq Acc Id: XM_063268661   ⟹   XP_063124731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,461,584 - 55,469,232 (-)NCBI
RefSeq Acc Id: XR_010055153
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,458,263 - 55,469,232 (-)NCBI
RefSeq Acc Id: NP_001099268   ⟸   NM_001105798
- UniProtKB: F1LQ70 (UniProtKB/Swiss-Prot),   A6HG42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034009   ⟸   ENSRNOT00000033098
RefSeq Acc Id: ENSRNOP00000069214   ⟸   ENSRNOT00000091131
RefSeq Acc Id: XP_038941407   ⟸   XM_039085479
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038941408   ⟸   XM_039085480
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063124729   ⟸   XM_063268659
- Peptide Label: isoform X1
- UniProtKB: A6HG42 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124730   ⟸   XM_063268660
- Peptide Label: isoform X4
- UniProtKB: A6HG43 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124731   ⟸   XM_063268661
- Peptide Label: isoform X5
- UniProtKB: A6HG43 (UniProtKB/TrEMBL)
Protein Domains
Lipoxygenase   PLAT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LQ70-F1-model_v2 AlphaFold F1LQ70 1-663 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697356
Promoter ID:EPDNEW_R7879
Type:single initiation site
Name:Alox12_1
Description:arachidonate 12-lipoxygenase, 12S type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01056,864,025 - 56,864,085EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311159 AgrOrtholog
BioCyc Gene G2FUF-24466 BioCyc
Ensembl Genes ENSRNOG00000027037 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033098 ENTREZGENE
  ENSRNOT00000033098.6 UniProtKB/Swiss-Prot
  ENSRNOT00000091131.2 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2 domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro LipOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_Fe_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_mml UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:287454 UniProtKB/TrEMBL
NCBI Gene 287454 ENTREZGENE
PANTHER POLYUNSATURATED FATTY ACID LIPOXYGENASE ALOX12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11771 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipoxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Alox12 PhenoGen
PRINTS LIPOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAMLPOXGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPOXYGENASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPOXYGENASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPOXYGENASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027037 RatGTEx
SMART LH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48484 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49723 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HG42 ENTREZGENE, UniProtKB/TrEMBL
  A6HG43 ENTREZGENE, UniProtKB/TrEMBL
  B4F796_RAT UniProtKB/TrEMBL
  F1LQ70 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Alox12  arachidonate 12-lipoxygenase, 12S type  Alox12  arachidonate 12-lipoxygenase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Alox12  arachidonate 12-lipoxygenase   Alox12_predicted  arachidonate 12-lipoxygenase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Alox12_predicted  arachidonate 12-lipoxygenase (predicted)      Symbol and Name status set to approved 70820 APPROVED