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Gene: Alox12 (arachidonate 12-lipoxygenase, 12S type) Rattus norvegicus
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Symbol: Alox12
Name: arachidonate 12-lipoxygenase, 12S type
RGD ID: 1311159
Description: Predicted to have arachidonate 12(S)-lipoxygenase activity; arachidonate 15-lipoxygenase activity; and linoleate 13S-lipoxygenase activity. Involved in several processes, including fatty acid metabolic process; positive regulation of endothelial tube morphogenesis; and regulation of apoptotic process. Localizes to cytosol and sarcolemma. Biomarker of congestive heart failure; hypertension; and obesity. Orthologous to human ALOX12 (arachidonate 12-lipoxygenase, 12S type); PARTICIPATES IN lipoxygenase mediated pathway of arachidonic acid metabolism; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benoxaprofen; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 12-LO; 12S-lipoxygenase; 12S-LOX; arachidonate (12S)-lipoxygenase; arachidonate (15S)-lipoxygenase; arachidonate 12-lipoxygenase; arachidonate 12-lipoxygenase, 12S-type; arachidonate 15-lipoxygenase,15S-type; linoleate 13S-lipoxygenase; lipoxin synthase 12-LO; LOC287454; MGC187960; platelet 12-LOX; platelet-type lipoxygenase 12; polyunsaturated fatty acid lipoxygenase ALOX12
Orthologs:
Homo sapiens (human) : ALOX12 (arachidonate 12-lipoxygenase, 12S type)  HGNC  Alliance
Mus musculus (house mouse) : Alox12 (arachidonate 12-lipoxygenase)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : ALOX12 (arachidonate 12-lipoxygenase, 12S type)
Canis lupus familiaris (dog) : ALOX12 (arachidonate 12-lipoxygenase, 12S type)
Sus scrofa (pig) : ALOX12 (arachidonate 12-lipoxygenase, 12S type)
Chlorocebus sabaeus (African green monkey) : ALOX12 (arachidonate 12-lipoxygenase, 12S type)
Heterocephalus glaber (naked mole-rat) : Alox12 (arachidonate 12-lipoxygenase, 12S type)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01056,851,734 - 56,864,049 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,851,734 - 56,864,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,595,898 - 56,608,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,080,603 - 57,092,874 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11057,095,024 - 57,106,540 (-)NCBI
Celera1054,109,834 - 54,122,106 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Alox12
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1311159
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.