Gene: Alox12 (arachidonate 12-lipoxygenase, 12S type) Rattus norvegicus
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Symbol: Alox12
Name: arachidonate 12-lipoxygenase, 12S type
Description: ENCODES a protein that exhibits arachidonate 12-lipoxygenase activity (ortholog); linoleate 13S-lipoxygenase activity (ortholog); INVOLVED IN aging; arachidonic acid metabolic process; cellular response to lipid; PARTICIPATES IN lipoxygenase mediated pathway of arachidonic acid metabolism; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; ASSOCIATED WITH Carotid Artery Injuries; congestive heart failure; hypertension; FOUND IN cytoplasm; cytosol; sarcolemma; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; benoxaprofen; bisphenol A
AGR Description: Predicted to have arachidonate 12-lipoxygenase activity and linoleate 13S-lipoxygenase activity; involved in several processes, including aging, carboxylic acid metabolic process, and positive regulation of macromolecule metabolic process; localizes to the cytosol and sarcolemma; biomarker of congestive heart failure, hypertension, and obesity; orthologous to human ALOX12 (arachidonate 12-lipoxygenase, 12S type).
Merged Description: Predicted to have arachidonate 12-lipoxygenase activity and linoleate 13S-lipoxygenase activity; involved in several processes, including aging, carboxylic acid metabolic process, and positive regulation of macromolecule metabolic process; localizes to the cytosol and sarcolemma; biomarker of congestive heart failure, hypertension, and obesity; orthologous to human ALOX12 (arachidonate 12-lipoxygenase, 12S type); PARTICIPATES IN lipoxygenase mediated pathway of arachidonic acid metabolism; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; benoxaprofen; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 12-LO; 12S-lipoxygenase; 12S-LOX; arachidonate 12-lipoxygenase; arachidonate 12-lipoxygenase, 12S-type; lipoxin synthase 12-LO; LOC287454; MGC187960; platelet 12-LOX; platelet-type lipoxygenase 12
Orthologs:
Homo sapiens (human) : ALOX12 (arachidonate 12-lipoxygenase, 12S type)  HGNC  Alliance
Mus musculus (house mouse) : Alox12 (arachidonate 12-lipoxygenase)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : ALOX12 (arachidonate 12-lipoxygenase, 12S type)
Canis lupus familiaris (dog) : ALOX12 (arachidonate 12-lipoxygenase, 12S type)
Sus scrofa (pig) : ALOX12 (arachidonate 12-lipoxygenase, 12S type)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01056,851,734 - 56,864,049 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01056,595,898 - 56,608,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,080,603 - 57,092,874 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11057,095,024 - 57,106,540 (-)NCBI
Celera1054,109,834 - 54,122,106 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Strain Sequence Variants (Rnor 5.0)

Additional Information

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Nomenclature History
  
More on Alox12
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1311159
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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