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Gene: P2rx1 (purinergic receptor P2X 1) Rattus norvegicus
Symbol: P2rx1
Name: purinergic receptor P2X 1
Description: Exhibits several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and zinc ion binding activity. Involved in several processes, including glutamatergic synaptic transmission; neuronal action potential; and regulation of presynaptic cytosolic calcium ion concentration. Localizes to several cellular components, including glutamatergic synapse; integral component of synaptic membrane; and membrane raft. Orthologous to human P2RX1 (purinergic receptor P2X 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 17beta-estradiol; acetamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATP receptor; P2X purinoceptor 1; P2X1; P2XMR; purinergic receptor P2X, ligand-gated ion channel, 1; RP-2 protein
Homo sapiens (human) : P2RX1 (purinergic receptor P2X 1)  HGNC  Alliance
Mus musculus (house mouse) : P2rx1 (purinergic receptor P2X, ligand-gated ion channel, 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : P2rx1 (purinergic receptor P2X 1)
Pan paniscus (bonobo/pygmy chimpanzee) : P2RX1 (purinergic receptor P2X 1)
Canis lupus familiaris (dog) : P2RX1 (purinergic receptor P2X 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : P2rx1 (purinergic receptor P2X 1)
Sus scrofa (pig) : P2RX1 (purinergic receptor P2X 1)
Chlorocebus sabaeus (African green monkey) : P2RX1 (purinergic receptor P2X 1)
Heterocephalus glaber (naked mole-rat) : P2rx1 (purinergic receptor P2X 1)
more info ...
Allele / Splice: P2rx1em1Mcwi   P2rx1em6Mcwi   P2rx1em7Mcwi  
Genetic Models: SS-P2rx1em7Mcwi SS-P2rx1em6Mcwi SS-P2rx1em1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01059,566,268 - 59,581,328 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1059,566,223 - 59,581,325 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01059,305,737 - 59,320,797 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41059,889,933 - 59,904,985 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11059,903,555 - 59,918,605 (+)NCBI
Celera1056,742,815 - 56,757,878 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on P2rx1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3240
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.