Nlgn2 (neuroligin 2) - Rat Genome Database

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Gene: Nlgn2 (neuroligin 2) Rattus norvegicus
Analyze
Symbol: Nlgn2
Name: neuroligin 2
RGD ID: 621118
Description: Predicted to enable several functions, including cell adhesion molecule binding activity; identical protein binding activity; and neurexin family protein binding activity. Involved in several processes, including positive regulation of protein localization; presynapse organization; and regulation of synapse assembly. Acts upstream of or within synapse organization. Located in several cellular components, including dendritic shaft; inhibitory synapse; and postsynaptic membrane. Is active in GABA-ergic synapse and postsynaptic specialization membrane. Biomarker of sciatic neuropathy and status epilepticus. Orthologous to human NLGN2 (neuroligin 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: neuroligin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21054,544,588 - 54,557,854 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,544,588 - 54,558,434 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,206,968 - 59,220,379 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01058,695,535 - 58,708,946 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01054,203,207 - 54,216,624 (-)NCBIRnor_WKY
Rnor_6.01056,431,586 - 56,444,847 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,431,573 - 56,444,847 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,176,705 - 56,189,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,646,081 - 56,678,060 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,659,705 - 56,691,680 (-)NCBI
Celera1053,698,870 - 53,712,041 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brain development  (IEP)
cell adhesion  (IEA)
chemical synaptic transmission  (IBA)
gephyrin clustering involved in postsynaptic density assembly  (IEA,ISO,ISS)
inhibitory synapse assembly  (IEA,ISO)
insulin metabolic process  (IDA)
jump response  (IMP)
locomotory exploration behavior  (IEA,ISO,ISS)
membrane assembly  (IEA)
modulation of chemical synaptic transmission  (IBA,ISO,ISS)
neuromuscular process controlling balance  (IEA,ISO,ISS)
neuron cell-cell adhesion  (IBA,IDA)
neurotransmitter-gated ion channel clustering  (IEA,ISO)
positive regulation of cell population proliferation  (IDA)
positive regulation of dendritic spine development  (IMP)
positive regulation of excitatory postsynaptic potential  (IEA,ISO,ISS)
positive regulation of inhibitory postsynaptic potential  (IEA,IMP,ISO)
positive regulation of insulin secretion  (IDA,IEA,IMP,ISO)
positive regulation of protein localization to synapse  (IEA,IMP,ISO)
positive regulation of synapse assembly  (IDA)
positive regulation of synaptic transmission, GABAergic  (IEA,ISO,ISS)
positive regulation of synaptic transmission, glutamatergic  (IEA,ISO,ISS)
positive regulation of synaptic vesicle clustering  (IEA,ISO)
positive regulation of t-SNARE clustering  (IDA)
postsynaptic density protein 95 clustering  (IEA,ISO,ISS)
postsynaptic membrane assembly  (IBA,IEA,ISO,ISS)
postsynaptic specialization assembly  (ISO)
presynaptic membrane assembly  (IBA,IDA,IEA,ISO)
protein localization to cell surface  (IEA,ISO)
protein localization to synapse  (ISO,ISS)
regulation of AMPA receptor activity  (IEA,ISO,ISS)
regulation of localization  (IEA)
regulation of membrane potential  (IEA)
regulation of nervous system process  (IEA)
regulation of presynapse assembly  (IDA,IMP)
regulation of respiratory gaseous exchange by nervous system process  (IEA,ISO,ISS)
sensory perception of pain  (IEA,ISO,ISS)
social behavior  (IMP)
synapse assembly  (IDA,IEA)
synapse organization  (IDA)
synaptic transmission, GABAergic  (IEA,ISO)
synaptic vesicle endocytosis  (IBA)
terminal button organization  (IMP)
thigmotaxis  (IMP)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Control of excitatory and inhibitory synapse formation by neuroligins. Chih B, etal., Science. 2005 Feb 25;307(5713):1324-8. Epub 2005 Jan 27.
2. Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. Chubykin AA, etal., J Biol Chem. 2005 Jun 10;280(23):22365-74. Epub 2005 Mar 29.
3. Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb. Clarris HJ, etal., Int J Dev Biol 2002;46(4):649-52.
4. Unexpected association of the "inhibitory" neuroligin 2 with excitatory PSD95 in neuropathic pain. Dolique T, etal., Pain. 2013 Nov;154(11):2529-46. doi: 10.1016/j.pain.2013.07.035. Epub 2013 Jul 25.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression. Hines RM, etal., J Neurosci. 2008 Jun 11;28(24):6055-67. doi: 10.1523/JNEUROSCI.0032-08.2008.
8. Structures, alternative splicing, and neurexin binding of multiple neuroligins. Ichtchenko K, etal., J Biol Chem 1996 Feb 2;271(5):2676-82.
9. Altered synaptic properties during integration of adult-born hippocampal neurons following a seizure insult. Jackson J, etal., PLoS One. 2012;7(4):e35557. doi: 10.1371/journal.pone.0035557. Epub 2012 Apr 23.
10. Postsynaptic scaffolding molecules modulate the localization of neuroligins. Levinson JN, etal., Neuroscience. 2010 Feb 3;165(3):782-93. doi: 10.1016/j.neuroscience.2009.11.016. Epub 2009 Nov 13.
11. An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Linhoff MW, etal., Neuron. 2009 Mar 12;61(5):734-49. doi: 10.1016/j.neuron.2009.01.017.
12. Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts. Loh KH, etal., Cell. 2016 Aug 25;166(5):1295-1307.e21. doi: 10.1016/j.cell.2016.07.041.
13. Synaptic localization of neuroligin 2 in the rodent retina: comparative study with the dystroglycan-containing complex. Lui L, etal., J Neurosci Res. 2010 Mar;88(4):837-49. doi: 10.1002/jnr.22258.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin. Poulopoulos A, etal., Neuron. 2009 Sep 10;63(5):628-42. doi: 10.1016/j.neuron.2009.08.023.
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Scheiffele P, etal., Cell. 2000 Jun 9;101(6):657-69.
20. Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. Suckow AT, etal., Endocrinology. 2008 Dec;149(12):6006-17. Epub 2008 Aug 28.
21. Transcellular neuroligin-2 interactions enhance insulin secretion and are integral to pancreatic beta cell function. Suckow AT, etal., J Biol Chem. 2012 Jun 8;287(24):19816-26. doi: 10.1074/jbc.M111.280537. Epub 2012 Apr 23.
22. Neuroligin 2 is exclusively localized to inhibitory synapses. Varoqueaux F, etal., Eur J Cell Biol. 2004 Sep;83(9):449-56.
23. GARLH Family Proteins Stabilize GABAA Receptors at Synapses. Yamasaki T, etal., Neuron. 2017 Mar 8;93(5):1138-1152.e6. doi: 10.1016/j.neuron.2017.02.023.
24. Down-regulation of mRNAs for synaptic adhesion molecules neuroligin-2 and -3 and synCAM1 in spinal motoneurons after axotomy. Zelano J, etal., J Comp Neurol. 2007 Jul 10;503(2):308-18.
Additional References at PubMed
PMID:9647694   PMID:11329178   PMID:15458844   PMID:15620359   PMID:15740699   PMID:16982420   PMID:17336090   PMID:17582332   PMID:18250328   PMID:19016888   PMID:21424692   PMID:21532576  
PMID:22871113   PMID:22960622   PMID:23426688   PMID:23451101   PMID:24213355   PMID:24613359   PMID:25565602   PMID:26152839   PMID:27035941   PMID:27805570   PMID:29715511   PMID:30602588  
PMID:30790215  


Genomics

Comparative Map Data
Nlgn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21054,544,588 - 54,557,854 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,544,588 - 54,558,434 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,206,968 - 59,220,379 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01058,695,535 - 58,708,946 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01054,203,207 - 54,216,624 (-)NCBIRnor_WKY
Rnor_6.01056,431,586 - 56,444,847 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,431,573 - 56,444,847 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,176,705 - 56,189,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,646,081 - 56,678,060 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,659,705 - 56,691,680 (-)NCBI
Celera1053,698,870 - 53,712,041 (-)NCBICelera
Cytogenetic Map10q24NCBI
NLGN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,404,653 - 7,419,860 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl177,404,874 - 7,419,860 (+)EnsemblGRCh38hg38GRCh38
GRCh37177,311,164 - 7,323,179 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,252,226 - 7,263,903 (+)NCBINCBI36Build 36hg18NCBI36
Build 34177,252,225 - 7,263,903NCBI
Celera177,337,380 - 7,349,064 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,205,598 - 7,217,206 (+)NCBIHuRef
CHM1_1177,320,590 - 7,332,275 (+)NCBICHM1_1
T2T-CHM13v2.0177,311,889 - 7,323,908 (+)NCBIT2T-CHM13v2.0
Nlgn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,713,949 - 69,728,610 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,713,948 - 69,728,610 (-)EnsemblGRCm39 Ensembl
GRCm381169,823,123 - 69,837,784 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,823,122 - 69,837,784 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,636,625 - 69,648,351 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,639,318 - 69,651,044 (-)NCBIMGSCv36mm8
Celera1177,384,083 - 77,395,807 (-)NCBICelera
Cytogenetic Map11B3NCBI
Nlgn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,504,974 - 9,520,059 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,504,974 - 9,520,059 (-)NCBIChiLan1.0ChiLan1.0
NLGN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1177,425,927 - 7,438,504 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0177,438,853 - 7,454,014 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NLGN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,338,602 - 32,351,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,340,335 - 32,352,412 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,476,574 - 32,491,676 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,444,141 - 32,459,248 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,446,860 - 32,457,104 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,409,378 - 32,424,482 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,368,131 - 32,383,214 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,545,377 - 32,560,482 (+)NCBIUU_Cfam_GSD_1.0
Nlgn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,218,152 - 47,230,462 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595692,334 - 704,602 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936595692,340 - 704,650 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLGN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,781,510 - 6,796,304 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,784,642 - 6,794,419 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,612,269 - 14,627,070 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nlgn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,022,717 - 10,034,624 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478610,019,307 - 10,034,624 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nlgn2
34 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:184
Count of miRNA genes:104
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000056871, ENSRNOT00000056872
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105220003059378278Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105379738558445852Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 4 4 74 20 32
Low 3 43 45 29 19 29 8 11 15 9 11 8
Below cutoff 8 8 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000056872   ⟹   ENSRNOP00000053713
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,544,588 - 54,557,854 (-)Ensembl
Rnor_6.0 Ensembl1056,431,573 - 56,444,847 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092459
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1056,437,578 - 56,441,502 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092662   ⟹   ENSRNOP00000075845
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,544,588 - 54,558,434 (-)Ensembl
Rnor_6.0 Ensembl1056,431,586 - 56,444,847 (-)Ensembl
RefSeq Acc Id: NM_053992   ⟹   NP_446444
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21054,544,588 - 54,557,854 (-)NCBI
Rnor_6.01056,431,586 - 56,444,847 (-)NCBI
Rnor_5.01056,176,705 - 56,189,966 (-)NCBI
RGSC_v3.41056,646,081 - 56,678,060 (-)RGD
Celera1053,698,870 - 53,712,041 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446444 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA97870 (Get FASTA)   NCBI Sequence Viewer  
  EDM04903 (Get FASTA)   NCBI Sequence Viewer  
  Q62888 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_446444   ⟸   NM_053992
- Peptide Label: precursor
- UniProtKB: Q62888 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075845   ⟸   ENSRNOT00000092662
RefSeq Acc Id: ENSRNOP00000053713   ⟸   ENSRNOT00000056872
Protein Domains
COesterase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62888-F1-model_v2 AlphaFold Q62888 1-836 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697327
Promoter ID:EPDNEW_R7852
Type:single initiation site
Name:Nlgn2_1
Description:neuroligin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01056,444,780 - 56,444,840EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621118 AgrOrtholog
BioCyc Gene G2FUF-24511 BioCyc
Ensembl Genes ENSRNOG00000015430 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000053713 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOP00000075845 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056872 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOT00000092662 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nlgn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NLGN2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117096 UniProtKB/Swiss-Prot
NCBI Gene 117096 ENTREZGENE
PANTHER PTHR43903:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nlgn2 PhenoGen
PRINTS NEUROLIGIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RRX0_RAT UniProtKB/TrEMBL
  F1LQ41_RAT UniProtKB/TrEMBL
  NLGN2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Nlgn2  neuroligin 2      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Nlgn2  neuroligin 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains an esterase homology domain, a highly conserved single transmembrane region, and a short cytoplasmic domain 729051
gene_physical_interaction binds to beta-neurexins 729051