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Gene: Aspa (aspartoacylase) Rattus norvegicus
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Symbol: Aspa
Name: aspartoacylase
Description: Exhibits identical protein binding activity. Involved in central nervous system myelination and positive regulation of oligodendrocyte differentiation. Localizes to the cytoplasm and nucleus. Used to study Canavan disease. Human ortholog(s) of this gene implicated in Canavan disease. Orthologous to human ASPA (aspartoacylase); PARTICIPATES IN Canavan disease pathway; alanine, aspartate and glutamate metabolic pathway; histidine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ACY-2; aminoacylase-2; MGC93407; MGC93408
Orthologs:
Homo sapiens (human) : ASPA (aspartoacylase)  HGNC  Alliance
Mus musculus (house mouse) : Aspa (aspartoacylase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aspa (aspartoacylase)
Pan paniscus (bonobo/pygmy chimpanzee) : ASPA (aspartoacylase)
Canis lupus familiaris (dog) : ASPA (aspartoacylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aspa (aspartoacylase)
Sus scrofa (pig) : ASPA (aspartoacylase)
more info ...
Allele / Splice: Aspaem31Kyo   Aspaem34Kyo   AspatmKyo  
Genetic Models: W-AspatmKyo F344-Aspaem31Kyo F344-Aspaem34Kyo
Is Marker For: Strains:   W-AspatmKyo   TRMR/Kyo   SER/Kyo   TRM/Kyo  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01059,839,693 - 59,888,244 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01059,578,788 - 59,627,450 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41060,178,509 - 60,199,207 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11060,192,134 - 60,212,830 (-)NCBI
Celera1057,043,025 - 57,063,351 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Aspa
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621693
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.