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Gene: Chrne (cholinergic receptor nicotinic epsilon subunit) Rattus norvegicus
Symbol: Chrne
Name: cholinergic receptor nicotinic epsilon subunit
RGD ID: 2353
Description: Exhibits acetylcholine-gated cation-selective channel activity. Involved in cation transport and skeletal muscle contraction. Localizes to acetylcholine-gated channel complex. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 4A; congenital myasthenic syndrome 4B; and congenital myasthenic syndrome 4C. Orthologous to human CHRNE (cholinergic receptor nicotinic epsilon subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: acetylcholine receptor epsilon; acetylcholine receptor subunit epsilon; cholinergic receptor, nicotinic epsilon; cholinergic receptor, nicotinic, epsilon; cholinergic receptor, nicotinic, epsilon (muscle); cholinergic receptor, nicotinic, epsilon polypeptide; epsilon-subunit; gene for acetylcholine receptor epsilon subunit; nAChR
Homo sapiens (human) : CHRNE (cholinergic receptor nicotinic epsilon subunit)  HGNC  Alliance
Mus musculus (house mouse) : Chrne (cholinergic receptor, nicotinic, epsilon polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrne (cholinergic receptor nicotinic epsilon subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRNE (cholinergic receptor nicotinic epsilon subunit)
Canis lupus familiaris (dog) : CHRNE (cholinergic receptor nicotinic epsilon subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrne (cholinergic receptor nicotinic epsilon subunit)
Sus scrofa (pig) : CHRNE (cholinergic receptor nicotinic epsilon subunit)
Chlorocebus sabaeus (African green monkey) : CHRNE (cholinergic receptor nicotinic epsilon subunit)
Heterocephalus glaber (naked mole-rat) : Chrne (cholinergic receptor nicotinic epsilon subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01057,238,960 - 57,246,750 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,238,946 - 57,243,435 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,984,503 - 56,992,199 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,497,192 - 57,501,511 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11057,510,815 - 57,515,134 (-)NCBI
Celera1054,476,876 - 54,481,195 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Chrne
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2353
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.