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Gene: Chrne (cholinergic receptor nicotinic epsilon subunit) Rattus norvegicus
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Symbol: Chrne
Name: cholinergic receptor nicotinic epsilon subunit
Description: Exhibits acetylcholine-gated cation-selective channel activity. Predicted to contribute to acetylcholine binding activity; acetylcholine receptor activity; and extracellular ligand-gated ion channel activity. Involved in cation transport and skeletal muscle contraction. Localizes to the acetylcholine-gated channel complex. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 4A; congenital myasthenic syndrome 4B; and congenital myasthenic syndrome 4C. Orthologous to human CHRNE (cholinergic receptor nicotinic epsilon subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: acetylcholine receptor epsilon; acetylcholine receptor subunit epsilon; cholinergic receptor, nicotinic epsilon; cholinergic receptor, nicotinic, epsilon; cholinergic receptor, nicotinic, epsilon (muscle); cholinergic receptor, nicotinic, epsilon polypeptide; epsilon-subunit; gene for acetylcholine receptor epsilon subunit; nAChR
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01057,238,960 - 57,246,750 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01056,984,503 - 56,992,199 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,497,192 - 57,501,511 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11057,510,815 - 57,515,134 (-)NCBI
Celera1054,476,876 - 54,481,195 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Chrne
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2353
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.