Alox15 (arachidonate 15-lipoxygenase) - Rat Genome Database

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Gene: Alox15 (arachidonate 15-lipoxygenase) Rattus norvegicus
Analyze
Symbol: Alox15
Name: arachidonate 15-lipoxygenase
RGD ID: 70493
Description: Enables hepoxilin A3 synthase activity; hepoxilin-epoxide hydrolase activity; and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in fatty acid metabolic process and positive regulation of heterotypic cell-cell adhesion. Located in cytosol. Biomarker of brain ischemia; congestive heart failure; and glomerulonephritis. Orthologous to human ALOX15 (arachidonate 15-lipoxygenase); PARTICIPATES IN lipoxygenase mediated pathway of arachidonic acid metabolism; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; INTERACTS WITH (5Z,8Z,11Z,13E)-15-HETE; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 12-LOX; 12/15-lipoxygenase; 12/15-LOX; 15-LOX; Alox12; Alox12l; arachidonate 12-lipoxygenase, leukocyte-type; arachidonate omega-6 lipoxygenase; hepoxilin A3 synthase Alox15; linoleate 13S-lipoxygenase; polyunsaturated fatty acid lipoxygenase ALOX15
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SD  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21055,060,169 - 55,068,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,060,412 - 55,068,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,739,979 - 59,748,431 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01059,228,481 - 59,236,931 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01054,727,685 - 54,736,135 (-)NCBIRnor_WKY
Rnor_6.01056,953,692 - 56,962,145 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,953,691 - 56,962,161 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,704,488 - 56,713,186 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,185,939 - 57,194,388 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11057,199,562 - 57,208,011 (-)NCBI
Celera1054,211,640 - 54,220,083 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,7-dihydropurine-6-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-oxoprostaglandin F1alpha  (ISO)
6-propyl-2-thiouracil  (EXP)
8-(4-chlorophenylthio)-cGMP  (ISO)
acetamide  (EXP)
acetylcholine  (ISO)
acrylamide  (EXP)
Actein  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Artemisic acid  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
aspartame  (ISO)
baicalein  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bifenthrin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
C60 fullerene  (EXP)
carbon nanotube  (ISO)
cis-caffeic acid  (ISO)
Cuprizon  (EXP)
Deoxycorticosterone acetate  (ISO)
diclofenac  (EXP)
dieldrin  (EXP)
dioxygen  (EXP)
elemental selenium  (EXP)
EPTC  (ISO)
esculetin  (ISO)
ethanol  (EXP)
fulvestrant  (ISO)
hexachlorobenzene  (EXP)
Honokiol  (ISO)
hydralazine  (ISO)
indole-3-methanol  (EXP)
lead diacetate  (EXP)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
losartan  (EXP)
lovastatin  (EXP)
masoprocol  (EXP,ISO)
mercaptopurine  (EXP)
metformin  (EXP)
methotrexate  (EXP)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
nickel atom  (ISO)
nitroglycerin  (EXP)
NS-398  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
prostaglandin E2  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
selenium atom  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
starch  (EXP)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (EXP)
toluene  (ISO)
topotecan  (EXP)
trans-caffeic acid  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
withaferin A  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (ISO)
antipyrine drug pathway  (ISO)
arachidonic acid metabolic pathway  (IEA,ISO)
atherosclerosis pathway  (ISO)
celecoxib pharmacodynamics pathway  (ISO)
diclofenac pharmacodynamics pathway  (ISO)
diflunisal pharmacodynamics pathway  (ISO)
etodolac pharmacodynamics pathway  (ISO)
fenoprofen pharmacodynamics pathway  (ISO)
flurbiprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
interleukin-4 signaling pathway  (ISO)
ketoprofen pharmacodynamics pathway  (ISO)
ketorolac pharmacodynamics pathway  (ISO)
leukotriene C4 synthase deficiency pathway  (ISO)
linoleic acid metabolic pathway  (IEA)
lipoxygenase mediated pathway of arachidonic acid metabolism  (IDA)
lornoxicam pharmacodynamics pathway  (ISO)
magnesium salicylate pharmacodynamics pathway  (ISO)
mefenamic acid pharmacodynamics pathway  (ISO)
meloxicam pharmacodynamics pathway  (ISO)
nabumetone pharmacodynamics pathway  (ISO)
naproxen pharmacodynamics pathway  (ISO)
paracetamol drug pathway  (ISO)
piroxicam pharmacodynamics pathway  (ISO)
salicylic acid pharmacodynamics pathway  (ISO)
sodium salicylate pharmacodynamics pathway  (ISO)
sulindac pharmacodynamics pathway  (ISO)
tenoxicam pharmacodynamics pathway  (ISO)
tiaprofenic acid pharmacodynamics pathway  (ISO)
tolmetin pharmacodynamics pathway  (ISO)
type 1 diabetes mellitus pathway  (ISO)
valdecoxib pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II. Alonso-Galicia M, etal., Am J Physiol Regul Integr Comp Physiol 2002 Jul;283(1):R60-8.
2. Regulation of neuronal type genes in congestive heart failure rats. Andersson KB, etal., Acta Physiol (Oxf). 2006 Jan;186(1):17-27.
3. Interdependence of lipoxin A4 and heme-oxygenase in counter-regulating inflammation during corneal wound healing. Biteman B, etal., FASEB J. 2007 Jul;21(9):2257-66. Epub 2007 Mar 23.
4. Effects of reduced glutathione on the 12-lipoxygenase pathways in rat platelets. Chang WC, etal., Biochem J 1982 Mar 15;202(3):771-6.
5. Catalytic consumption of nitric oxide by 12/15- lipoxygenase: inhibition of monocyte soluble guanylate cyclase activation. Coffey MJ, etal., Proc Natl Acad Sci U S A 2001 Jul 3;98(14):8006-11.
6. Neuroprotection of early and short-time applying atorvastatin in the acute phase of cerebral ischemia: down-regulated 12/15-LOX, p38MAPK and cPLA2 expression, ameliorated BBB permeability. Cui L, etal., Brain Res. 2010 Apr 14;1325:164-73. Epub 2010 Feb 16.
7. 12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo. Dioszeghy V, etal., J Immunol. 2008 Nov 1;181(9):6514-24.
8. Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase. Emerson MR and LeVine SM, Brain Res. 2004 Sep 17;1021(1):140-5.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. Gregus AM, etal., FASEB J. 2013 May;27(5):1939-49. doi: 10.1096/fj.12-217414. Epub 2013 Feb 4.
11. A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense. Gronert K, etal., J Biol Chem. 2005 Apr 15;280(15):15267-78. Epub 2005 Feb 11.
12. Arachidonate 12-lipoxygenase of rat pineal glands: catalytic properties and primary structure deduced from its cDNA. Hada T, etal., Biochim Biophys Acta 1994 Mar 3;1211(2):221-8.
13. 12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels. Hajek AR, etal., J Allergy Clin Immunol. 2008 Sep;122(3):633-9.e3. Epub 2008 Aug 9.
14. Gene Data File Integration of LocusLink data, October 12, 2001
15. Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia. Jin G, etal., Stroke. 2008 Sep;39(9):2538-43. Epub 2008 Jul 17.
16. Co-regulated expression of glomerular 12/15-lipoxygenase and interleukin-4 mRNAs in rat nephrotoxic nephritis. Katoh T, etal., Kidney Int. 1994 Aug;46(2):341-9.
17. Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure. Kayama Y, etal., J Exp Med. 2009 Jul 6;206(7):1565-74. Epub 2009 Jun 22.
18. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
19. 12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis. Kronke G, etal., J Immunol. 2009 Sep 1;183(5):3383-9. Epub 2009 Aug 12.
20. Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs. Li SL, etal., J Lipid Res. 2005 Feb;46(2):220-9. Epub 2004 Dec 1.
21. Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model. Mabalirajan U, etal., J Appl Physiol. 2009 Oct;107(4):1285-92. Epub 2009 Jul 23.
22. Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease. Martinez-Clemente M, etal., Hepatology. 2010 Dec;52(6):1980-91. doi: 10.1002/hep.23928. Epub 2010 Oct 21.
23. Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes. McDuffie M, etal., Diabetes. 2008 Jan;57(1):199-208. Epub 2007 Oct 16.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. The rat leukocyte-type 12-lipoxygenase exhibits an intrinsic hepoxilin A3 synthase activity. Nigam S, etal., J Biol Chem. 2004 Jul 9;279(28):29023-30. Epub 2004 May 3.
27. Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies. Obrosova IG, etal., Am J Pathol. 2010 Sep;177(3):1436-47. Epub 2010 Aug 19.
28. Overexpression of leukocyte-type 12-lipoxygenase promotes W256 tumor cell survival by enhancing alphavbeta5 expression. Pidgeon GP, etal., Int J Cancer 2003 Jul 1;105(4):459-71.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
31. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
32. 12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress. Pratico D, etal., Am J Pathol. 2004 May;164(5):1655-62.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. A microarray study of gene expression profiles in nasal polyps. Rostkowska-Nadolska B, etal., Auris Nasus Larynx. 2011 Feb;38(1):58-64. Epub 2010 Jun 15.
37. 12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice. Sears DD, etal., PLoS One. 2009 Sep 29;4(9):e7250.
38. Additive anti-atherogenic effect of thromboxane receptor antagonism with 12/15lipoxygenase gene disruption in apolipoprotein E-deficient mice. Tang L, etal., Atherosclerosis. 2008 Aug;199(2):265-70. Epub 2008 Jan 22.
39. Molecular cloning of a 12-lipoxygenase cDNA from rat brain. Watanabe T, etal., Eur J Biochem 1993 Mar 1;212(2):605-12.
40. Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase. Yang H, etal., Biol Psychiatry. 2010 Nov 15;68(10):922-9. Epub 2010 Jun 8.
41. Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI). Zarbock A, etal., J Immunol. 2009 Oct 1;183(7):4715-22. Epub 2009 Sep 14.
Additional References at PubMed
PMID:1944593   PMID:8188678   PMID:8305485   PMID:8334154   PMID:8798642   PMID:10432118   PMID:11278875   PMID:14716014   PMID:15105833   PMID:15107407   PMID:15777282   PMID:15878884  
PMID:16198304   PMID:16199435   PMID:16514433   PMID:17052953   PMID:17426145   PMID:17977660   PMID:18258795   PMID:18680775   PMID:19095999   PMID:19528634   PMID:19900087   PMID:21536676  
PMID:21831839   PMID:22210710   PMID:22215650   PMID:22503541   PMID:22982617   PMID:23242647   PMID:23493287   PMID:24282679   PMID:24465846   PMID:25293588   PMID:25605873   PMID:26514267  
PMID:26871724   PMID:28024685   PMID:28181190  


Genomics

Comparative Map Data
Alox15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21055,060,169 - 55,068,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,060,412 - 55,068,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,739,979 - 59,748,431 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01059,228,481 - 59,236,931 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01054,727,685 - 54,736,135 (-)NCBIRnor_WKY
Rnor_6.01056,953,692 - 56,962,145 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,953,691 - 56,962,161 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,704,488 - 56,713,186 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,185,939 - 57,194,388 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11057,199,562 - 57,208,011 (-)NCBI
Celera1054,211,640 - 54,220,083 (-)NCBICelera
Cytogenetic Map10q24NCBI
ALOX15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,630,919 - 4,641,678 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl174,630,919 - 4,642,294 (-)EnsemblGRCh38hg38GRCh38
GRCh37174,534,214 - 4,544,973 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,480,963 - 4,491,709 (-)NCBINCBI36Build 36hg18NCBI36
Build 34174,480,964 - 4,491,709NCBI
Celera174,546,922 - 4,554,338 (-)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef174,423,571 - 4,434,147 (-)NCBIHuRef
CHM1_1174,542,997 - 4,553,746 (-)NCBICHM1_1
T2T-CHM13v2.0174,520,655 - 4,531,416 (-)NCBIT2T-CHM13v2.0
Alox15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,234,973 - 70,279,465 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,234,978 - 70,242,857 (-)EnsemblGRCm39 Ensembl
GRCm381170,344,147 - 70,390,538 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,344,152 - 70,352,031 (-)EnsemblGRCm38mm10GRCm38
MGSCv371170,157,649 - 70,165,533 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,160,348 - 70,168,210 (-)NCBIMGSCv36mm8
Celera1177,888,721 - 77,896,673 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
Alox15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546710,032,792 - 10,039,789 (-)NCBIChiLan1.0ChiLan1.0
ALOX15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1174,677,125 - 4,687,669 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl174,677,125 - 4,687,669 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0174,686,339 - 4,696,877 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ALOX15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,883,544 - 31,891,357 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,882,501 - 32,038,119 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,022,707 - 32,030,999 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0531,988,523 - 31,996,819 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl531,988,497 - 31,996,890 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1531,954,788 - 31,963,077 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0531,914,466 - 31,922,749 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,090,734 - 32,099,028 (+)NCBIUU_Cfam_GSD_1.0
Alox15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560252,659,633 - 52,689,018 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366773,232,183 - 3,241,253 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366773,232,183 - 3,241,307 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALOX15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,112,795 - 4,121,764 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl164,111,151 - 4,121,645 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605917,518,868 - 17,530,240 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Alox15
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:64
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000026038
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105220003059378278Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105379738558445852Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat

Markers in Region
RH141184  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21055,060,541 - 55,060,759 (+)MAPPERmRatBN7.2
Rnor_6.01056,953,823 - 56,954,040NCBIRnor6.0
Rnor_5.01056,704,625 - 56,704,842UniSTSRnor5.0
RGSC_v3.41057,186,070 - 57,186,287UniSTSRGSC3.4
Celera1054,211,771 - 54,211,988UniSTS
Cytogenetic Map10q24UniSTS
PMC126639P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21055,060,894 - 55,061,193 (+)MAPPERmRatBN7.2
Rnor_6.01056,954,176 - 56,954,474NCBIRnor6.0
Rnor_5.01056,704,978 - 56,705,276UniSTSRnor5.0
RGSC_v3.41057,186,423 - 57,186,722UniSTSRGSC3.4
Celera1054,212,124 - 54,212,423UniSTS
Cytogenetic Map10q24UniSTS


Related Rat Strains
The following Strains have been annotated to Alox15
SD


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2 1
Medium 14 16 13 10 13 2 2 16 10 12 10 2
Low 3 29 41 28 7 28 5 6 58 25 28 5
Below cutoff 1 3 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026038   ⟹   ENSRNOP00000026038
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1055,060,412 - 55,068,859 (-)Ensembl
Rnor_6.0 Ensembl1056,953,691 - 56,962,161 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113835   ⟹   ENSRNOP00000091973
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1055,060,412 - 55,068,874 (-)Ensembl
RefSeq Acc Id: NM_031010   ⟹   NP_112272
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21055,060,411 - 55,068,859 (-)NCBI
Rnor_6.01056,953,692 - 56,962,140 (-)NCBI
Rnor_5.01056,704,488 - 56,713,186 (-)NCBI
RGSC_v3.41057,185,939 - 57,194,388 (-)RGD
Celera1054,211,640 - 54,220,083 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246824   ⟹   XP_006246886
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21055,060,169 - 55,068,885 (-)NCBI
Rnor_6.01056,953,692 - 56,962,145 (-)NCBI
Rnor_5.01056,704,488 - 56,713,186 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086930   ⟹   XP_038942858
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21055,060,169 - 55,068,619 (-)NCBI
RefSeq Acc Id: XM_039086932   ⟹   XP_038942860
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21055,065,003 - 55,068,653 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_112272   ⟸   NM_031010
- UniProtKB: Q02759 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006246886   ⟸   XM_006246824
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AV04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026038   ⟸   ENSRNOT00000026038
RefSeq Acc Id: XP_038942858   ⟸   XM_039086930
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038942860   ⟸   XM_039086932
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000091973   ⟸   ENSRNOT00000113835
Protein Domains
Lipoxygenase   PLAT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02759-F1-model_v2 AlphaFold Q02759 1-663 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697357
Promoter ID:EPDNEW_R7880
Type:single initiation site
Name:Alox15_1
Description:arachidonate 15-lipoxygenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01056,962,157 - 56,962,217EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70493 AgrOrtholog
BioCyc Gene G2FUF-24464 BioCyc
Ensembl Genes ENSRNOG00000019183 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000026038 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000091973 ENTREZGENE
  ENSRNOP00000091973.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026038 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000113835 ENTREZGENE
  ENSRNOT00000113835.1 UniProtKB/TrEMBL
InterPro LipOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_Fe_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_mml UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT_LOX_verte UniProtKB/Swiss-Prot
KEGG Report rno:81639 UniProtKB/Swiss-Prot
NCBI Gene 81639 ENTREZGENE
PANTHER PTHR11771 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipoxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Alox15 PhenoGen
PRINTS LIPOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAMLPOXGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPOXYGENASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPOXYGENASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPOXYGENASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48484 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49723 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AV04 ENTREZGENE, UniProtKB/TrEMBL
  LOX15_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary F1MA51 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Alox15  arachidonate 15-lipoxygenase    arachidonate 12-lipoxygenase  Name updated 1299863 APPROVED
2004-09-10 Alox15  arachidonate 12-lipoxygenase  Alox12    Symbol and Name updated 1299863 APPROVED
2002-06-10 Alox12  arachidonate 12-lipoxygenase      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization cytosolic 70288
gene_disease elevated in smooth muscle of angiotensin (ang) II-dependent hypertensive rats 70288
gene_disease inhibition of activity reduces blood pressure in hypertensive rats and ang II-induced smooth muscle hypertrophy 70288
gene_disease required for neointimal thickening in balloon injured rat aortae 70288
gene_expression may be predominant in pineal gland 70288
gene_function functions as a oxygenase and has 14,15-leukotriene a4 synthase activity 724707
gene_function oxidizes arachidonic acid into hydroperoxyeixos-atetraenoic acid (12-HPETE) and 12-L-hydroxyeicosa-5,8,10,14-tetraenoic acid (12-HETE) 70287
gene_function oxidizes arachidonic acid into hydroperoxyeixos-atetraenoic acid (12-HPETE) and 12-L-hydroxyeicosa-5,8,10,14-tetraenoic acid (12-HETE) 70288
gene_process active in synthesis of bioactive prostagladins, thromboxanes and leukotrienes 70287
gene_process active in synthesis of bioactive prostagladins, thromboxanes and leukotrienes 70288
gene_regulation production in the kidney and peripheral vasculature is increased by acute and chronic elevations in circulating Ang II levels 628571