Gene: Alox15 (arachidonate 15-lipoxygenase) Rattus norvegicus
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Symbol: Alox15
Name: arachidonate 15-lipoxygenase
Description: ENCODES a protein that exhibits arachidonate 12-lipoxygenase activity; arachidonate 15-lipoxygenase activity; hepoxilin A3 synthase activity; INVOLVED IN arachidonic acid metabolic process; hepoxilin biosynthetic process; lipoxygenase pathway; PARTICIPATES IN lipoxygenase mediated pathway of arachidonic acid metabolism; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; ASSOCIATED WITH brain ischemia; congestive heart failure; glomerulonephritis; FOUND IN cytosol; cytoplasm (ortholog); extrinsic component of cytoplasmic side of plasma membrane (ortholog); INTERACTS WITH (5Z,8Z,11Z,13E)-15-HETE; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine
AGR Description: Exhibits hepoxilin A3 synthase activity, hepoxilin-epoxide hydrolase activity, and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; involved in carboxylic acid metabolic process and positive regulation of heterotypic cell-cell adhesion; localizes to the cytosol; biomarker of brain ischemia, congestive heart failure, and glomerulonephritis; orthologous to human ALOX15 (arachidonate 15-lipoxygenase).
Merged Description: Exhibits hepoxilin A3 synthase activity, hepoxilin-epoxide hydrolase activity, and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; involved in carboxylic acid metabolic process and positive regulation of heterotypic cell-cell adhesion; localizes to the cytosol; biomarker of brain ischemia, congestive heart failure, and glomerulonephritis; orthologous to human ALOX15 (arachidonate 15-lipoxygenase); PARTICIPATES IN lipoxygenase mediated pathway of arachidonic acid metabolism; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; INTERACTS WITH (5Z,8Z,11Z,13E)-15-HETE; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 12-LOX; 12/15-lipoxygenase; 12/15-LOX; 15-LOX; Alox12; Alox12l; arachidonate 12-lipoxygenase, leukocyte-type; arachidonate omega-6 lipoxygenase
Orthologs:
Homo sapiens (human) : ALOX15 (arachidonate 15-lipoxygenase)  HGNC  Alliance
Mus musculus (house mouse) : Alox15 (arachidonate 15-lipoxygenase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alox15 (arachidonate 15-lipoxygenase)
Pan paniscus (bonobo/pygmy chimpanzee) : ALOX15 (arachidonate 15-lipoxygenase)
Canis lupus familiaris (dog) : ALOX15 (arachidonate 15-lipoxygenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alox15 (arachidonate 15-lipoxygenase)
Sus scrofa (pig) : ALOX15 (arachidonate 15-lipoxygenase)
more info ...
Is Marker For: Strains:   SD  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01056,953,692 - 56,962,145 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01056,704,488 - 56,713,186 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,185,939 - 57,194,388 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11057,199,562 - 57,208,011 (-)NCBI
Celera1054,211,640 - 54,220,083 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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More on Alox15
Alliance Gene
NCBI Gene
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RGD Object Information
RGD ID: 70493
Created: 2002-05-02
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.