Exhibits hepoxilin A3 synthase activity; hepoxilin-epoxide hydrolase activity; and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in fatty acid metabolic process and positive regulation of heterotypic cell-cell adhesion. Localizes to cytosol. Biomarker of brain ischemia; congestive heart failure; and glomerulonephritis. Orthologous to human ALOX15 (arachidonate 15-lipoxygenase); PARTICIPATES IN lipoxygenase mediated pathway of arachidonic acid metabolism; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; INTERACTS WITH (5Z,8Z,11Z,13E)-15-HETE; 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione.
[IL4 protein co-treated with Arachidonic Acid] results in increased activity of ALOX15 protein, [IL4 protein co-treated with Arachidonic Acid] results in increased expression of ALOX15 mRNA
[caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein] more ...
Masoprocol inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5 more ...
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ALOX15 mRNA, [Sodium Glutamate co-treated with High Fructose Corn Syrup] results in increased expression of ALOX15 mRNA
[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of ALOX15 protein] which results in increased chemical synthesis of 13-hydroxy-9 more ...
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of ALOX15 mRNA, N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of ALOX15 protein
APOD protein affects the reaction [Paraquat results in decreased expression of ALOX15 mRNA], Paraquat affects the reaction [APOD protein affects the expression of ALOX15 mRNA]
[caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein] more ...
[caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein] more ...
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Gene-Chemical Interaction Annotations
