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Gene: Nlrp1a (NLR family, pyrin domain containing 1A) Mus musculus
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Symbol:
Nlrp1a
Name:
NLR family, pyrin domain containing 1A
RGD ID:
1623841
MGI Page
MGI
Description:
Predicted to have scaffold protein binding activity. Involved in several processes, including positive regulation of interleukin-1 beta production; programmed necrotic cell death; and response to muramyl dipeptide. Predicted to localize to inflammasome complex and neuronal cell body. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1); PARTICIPATES IN interleukin-1 signaling pathway; NOD-like receptor signaling pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; carbon nanotube.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
CARD7; caspase recruitment domain protein; caspase recruitment domain-containing protein 7; death effector filament-forming Ced-4-like apoptosis protein; DEFCAP; Gm14; Gm15; N; NAC; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD containing protein 1; NACHT, LRR and PYD domains-containing protein 1a; NACHT/LRR/pyrin domain-containing protein 1; Nalp1; Nalp1a; NLR family, pyrin domain containing 1; NLR family, pyrin domain containing 1A, CAST/EiJ strain specific; NLR family, pyrin domain containing 1A, PWK/PhJ strain specific; NLR family, pyrin domain containing 1A, WSB/EiJ strain specific; Nlrp1; nucleotide-binding domain and caspase recruitment domain; PP1044
RGD Orthologs
Alliance Genes
More Info
more info ...
More Info
Related Pseudogenes:
Nlrp1c-ps
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 11 70,982,023 - 71,035,780 (-) NCBI GRCm39 mm39 GRCm38 11 71,091,197 - 71,144,969 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 11 71,092,236 - 71,144,704 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 11 70,904,699 - 70,958,206 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 11 70,908,431 - 70,958,561 (-) NCBI mm8 Celera 11 78,634,796 - 78,688,328 (-) NCBI Celera Cytogenetic Map 11 B4 NCBI cM Map 11 43.21 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Disease Annotations - ClinVar
Imported Disease Annotations - CTD
Imported Disease Annotations - OMIM
1,2-dichloroethane increases expression EXP 6480464 ethylene dichloride results in increased expression of NLRP1A mRNA CTD PMID:28960355 17beta-estradiol multiple interactions ISO RGD:1322162 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of NLRP1 mRNA CTD PMID:30165855 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of NLRP1A mRNA CTD PMID:21570461 acetamide increases expression ISO RGD:1310963 6480464 acetamide results in increased expression of NLRP1A mRNA CTD PMID:31881176 acrolein multiple interactions ISO RGD:1322162 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of NLRP1 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of NLRP1 mRNA CTD PMID:32699268 aflatoxin B2 increases methylation ISO RGD:1322162 6480464 aflatoxin B2 results in increased methylation of NLRP1 intron CTD PMID:30157460 alpha-pinene multiple interactions ISO RGD:1322162 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of NLRP1 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of NLRP1 mRNA CTD PMID:32699268 arsenite(3-) affects expression ISO RGD:1322162 6480464 arsenite affects the expression of NLRP1 mRNA CTD PMID:22959463 arsenous acid multiple interactions ISO RGD:1322162 6480464 [sanguinarine co-treated with Arsenic Trioxide] results in increased expression of NLRP1 mRNA CTD PMID:24345465 arsenous acid increases expression ISO RGD:1322162 6480464 Arsenic Trioxide results in increased expression of NLRP1 mRNA CTD PMID:24345465 ATP multiple interactions ISO RGD:1322162 6480464 [Lipopolysaccharides co-treated with Adenosine Triphosphate co-treated with resveratrol] results in increased expression of NLRP1 mRNA CTD PMID:24149798 beauvericin increases expression ISO RGD:1322162 6480464 beauvericin results in increased expression of NLRP1 mRNA CTD PMID:29203277 benzo[a]pyrene affects methylation ISO RGD:1322162 6480464 Benzoapyrene affects the methylation of NLRP1 intron, Benzoapyrene affects the methylation of NLRP1 promoter CTD PMID:27901495 , PMID:30157460 benzo[a]pyrene increases expression ISO RGD:1322162 6480464 Benzoapyrene results in increased expression of NLRP1 mRNA CTD PMID:32234424 benzo[a]pyrene diol epoxide I increases expression ISO RGD:1322162 6480464 7 more ... CTD PMID:20382639 benzo[e]pyrene increases methylation ISO RGD:1322162 6480464 benzoepyrene results in increased methylation of NLRP1 intron CTD PMID:30157460 bisphenol A decreases expression ISO RGD:1310963 6480464 bisphenol A results in decreased expression of NLRP1 mRNA, bisphenol A results in decreased expression of NLRP1A mRNA CTD PMID:25181051 , PMID:30816183 calcitriol increases expression ISO RGD:1322162 6480464 Calcitriol results in increased expression of NLRP1 mRNA CTD PMID:16002434 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon results in decreased expression of NLRP1A mRNA CTD PMID:25554681 cisplatin multiple interactions ISO RGD:1322162 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of NLRP1 mRNA, [Cisplatin co-treated with panobinostat] affects the expression of NLRP1 mRNA CTD PMID:21791302 , PMID:27392435 cisplatin increases expression ISO RGD:1322162 6480464 Cisplatin results in increased expression of NLRP1 mRNA CTD PMID:27392435 cobalt dichloride decreases expression ISO RGD:1322162 6480464 cobaltous chloride results in decreased expression of NLRP1 mRNA CTD PMID:19320972 copper atom multiple interactions ISO RGD:1322162 6480464 [NSC 689534 binds to Copper] which results in increased expression of NLRP1 mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:1322162 6480464 [NSC 689534 binds to Copper] which results in increased expression of NLRP1 mRNA CTD PMID:20971185 copper(II) sulfate decreases expression ISO RGD:1322162 6480464 Copper Sulfate results in decreased expression of NLRP1 mRNA CTD PMID:19549813 dextran sulfate multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of NLRP1A mRNA CTD PMID:29950665 diarsenic trioxide multiple interactions ISO RGD:1322162 6480464 [sanguinarine co-treated with Arsenic Trioxide] results in increased expression of NLRP1 mRNA CTD PMID:24345465 diarsenic trioxide increases expression ISO RGD:1322162 6480464 Arsenic Trioxide results in increased expression of NLRP1 mRNA CTD PMID:24345465 diazinon affects expression ISO RGD:1310963 6480464 Diazinon affects the expression of NLRP1A mRNA CTD PMID:22546817 diclofenac multiple interactions ISO RGD:1310963 6480464 Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of NLRP1A protein] CTD PMID:25450234 dicrotophos increases expression ISO RGD:1322162 6480464 dicrotophos results in increased expression of NLRP1 mRNA CTD PMID:28302478 doxorubicin increases expression ISO RGD:1322162 6480464 Doxorubicin results in increased expression of NLRP1 mRNA CTD PMID:29803840 lipopolysaccharide multiple interactions ISO RGD:1322162 6480464 [Lipopolysaccharides co-treated with Adenosine Triphosphate co-treated with resveratrol] results in increased expression of NLRP1 mRNA CTD PMID:24149798 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of NLRP1A mRNA CTD PMID:22147977 luteolin multiple interactions ISO RGD:1310963 6480464 Luteolin inhibits the reaction [Freund's Adjuvant results in increased expression of NLRP1A protein] CTD PMID:25450234 mercury atom decreases expression ISO RGD:1322162 6480464 Mercury results in decreased expression of NLRP1 mRNA CTD PMID:19937285 mercury(0) decreases expression ISO RGD:1322162 6480464 Mercury results in decreased expression of NLRP1 mRNA CTD PMID:19937285 methapyrilene increases methylation ISO RGD:1322162 6480464 Methapyrilene results in increased methylation of NLRP1 intron CTD PMID:30157460 ozone multiple interactions ISO RGD:1322162 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of NLRP1 mRNA more ... CTD PMID:32699268 p-menthan-3-ol increases expression ISO RGD:1322162 6480464 Menthol results in increased expression of NLRP1 mRNA CTD PMID:26760959 panobinostat multiple interactions ISO RGD:1322162 6480464 [Cisplatin co-treated with panobinostat] affects the expression of NLRP1 mRNA CTD PMID:21791302 resveratrol multiple interactions ISO RGD:1322162 6480464 [Lipopolysaccharides co-treated with Adenosine Triphosphate co-treated with resveratrol] results in increased expression of NLRP1 mRNA CTD PMID:24149798 resveratrol increases expression ISO RGD:1322162 6480464 resveratrol results in increased expression of NLRP1 mRNA CTD PMID:25436977 sanguinarine multiple interactions ISO RGD:1322162 6480464 [sanguinarine co-treated with arsenic trioxide] results in increased expression of NLRP1 mRNA CTD PMID:24345465 sanguinarine increases expression ISO RGD:1322162 6480464 sanguinarine results in increased expression of NLRP1 mRNA CTD PMID:24345465 silver atom increases expression EXP 6480464 Silver results in increased expression of NLRP1A mRNA CTD PMID:27131904 silver(0) increases expression EXP 6480464 Silver results in increased expression of NLRP1A mRNA CTD PMID:27131904 sodium arsenite affects methylation ISO RGD:1322162 6480464 sodium arsenite affects the methylation of NLRP1 gene CTD PMID:28589171 titanium dioxide multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of NLRP1A mRNA CTD PMID:29950665 valproic acid increases methylation ISO RGD:1322162 6480464 Valproic Acid results in increased methylation of NLRP1 gene CTD PMID:29154799 valproic acid increases expression ISO RGD:1322162 6480464 Valproic Acid results in increased expression of NLRP1 mRNA CTD PMID:19101580 , PMID:24935251 valproic acid affects expression ISO RGD:1322162 6480464 Valproic Acid affects the expression of NLRP1 mRNA CTD PMID:25979313 zinc atom increases expression ISO RGD:1322162 6480464 Zinc deficiency results in increased expression of NLRP1 mRNA CTD PMID:22171008 zinc(0) increases expression ISO RGD:1322162 6480464 Zinc deficiency results in increased expression of NLRP1 mRNA CTD PMID:22171008
Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process involved_in ISO RGD:1322162 9068941 PMID:15212762 HGNC-UCL PMID:15212762 activation of cysteine-type endopeptidase activity involved in apoptotic process IBA PANTHER:PTN002931183 2290270 MGI:6201960 , PMID:21873635 GO_Central MGI:6201960 , PMID:21873635 antiviral innate immune response involved_in ISO RGD:1322162 9068941 PMID:33093214 UniProt PMID:33093214 defense response to bacterium IDA 2290270 MGI:3583691 , PMID:16429160 MGI MGI:3583691 , PMID:16429160 defense response to virus involved_in ISO RGD:1322162 9068941 PMID:33093214 , PMID:33243852 UniProt PMID:33093214 , PMID:33243852 inflammatory response IEA InterPro:IPR033516 2290270 UniProt GO_REF:0000002, MGI:2152098 innate immune response IEA InterPro:IPR033516 2290270 UniProt GO_REF:0000002, MGI:2152098 neuron apoptotic process involved_in ISO RGD:1322162 9068941 PMID:15212762 HGNC-UCL PMID:15212762 NLRP1 inflammasome complex assembly involved_in ISO RGD:1322162 9068941 PMID:27662089 , PMID:31484767 UniProt PMID:27662089 , PMID:31484767 positive regulation of interleukin-1 beta production IDA 2290270 MGI:4943384 , PMID:18511561 BHF-UCL MGI:4943384 , PMID:18511561 positive regulation of interleukin-1 beta production involved_in ISO RGD:1322162 9068941 PMID:33243852 UniProt PMID:33243852 programmed necrotic cell death IDA 2290270 MGI:3583691 , PMID:16429160 MGI MGI:3583691 , PMID:16429160 pyroptosis involved_in ISO RGD:1322162 9068941 PMID:33093214 UniProt PMID:33093214 regulation of apoptotic process IEA InterPro:IPR001315 2290270 UniProt GO_REF:0000002, MGI:2152098 response to muramyl dipeptide IDA 2290270 MGI:4943384 , PMID:18511561 BHF-UCL MGI:4943384 , PMID:18511561 self proteolysis involved_in ISO RGD:1322162 9068941 PMID:33093214 UniProt PMID:33093214
Molecular Function
ATP binding IEA UniProtKB-KW:KW-0067 2290270 UniProt GO_REF:0000004, MGI:1354194 ATP binding enables ISO RGD:1322162 9068941 PMID:15212762 , PMID:33243852 HGNC-UCL PMID:15212762 , PMID:33243852 ATPase activity enables ISO RGD:1322162 9068941 PMID:33243852 UniProt PMID:33243852 double-stranded DNA binding enables ISO RGD:1322162 9068941 PMID:33243852 UniProt PMID:33243852 double-stranded RNA binding enables ISO RGD:1322162 9068941 PMID:33243852 UniProt PMID:33243852 enzyme binding enables ISO UniProtKB:P42575 9068941 PMID:11076957 UniProt PMID:11076957 nucleotide binding IEA UniProtKB-KW:KW-0547 2290270 UniProt GO_REF:0000004, MGI:1354194 protein binding enables ISO UniProtKB:Q9HC29 9068941 PMID:19337385 BHF-UCL PMID:19337385 protein binding enables ISO UniProtKB:Q07817 9068941 PMID:17418785 IntAct PMID:17418785 protein binding enables ISO UniProtKB:Q07817-1 9068941 PMID:19223583 IntAct PMID:19223583 protein binding enables ISO UniProtKB:P29466 9068941 PMID:15107016 more ... IntAct PMID:15107016 more ... protein binding enables ISO UniProtKB:Q9NPP4 9068941 PMID:11472070 , PMID:15107016 HGNC-UCL PMID:11472070 , PMID:15107016 protein binding enables ISO UniProtKB:P19525 9068941 PMID:22801494 UniProt PMID:22801494 protein binding enables ISO UniProtKB:P10415 9068941 PMID:17418785 , PMID:19223583 IntAct PMID:17418785 , PMID:19223583 protein binding IPI UniProtKB:Q80SY9 2290270 MGI:4943384 , PMID:18511561 BHF-UCL MGI:4943384 , PMID:18511561 protein binding enables ISO UniProtKB:Q9ULZ3 9068941 PMID:17418785 IntAct PMID:17418785 protein domain specific binding enables ISO UniProtKB:O95361 9068941 PMID:16575408 UniProt PMID:16575408 scaffold protein binding ISO RGD:1310963 2290270 MGI GO_REF:0000096, MGI:4417868
Imported Annotations - KEGG (archival)
References
Additional References at PubMed
Genomics
QTLs in Region (GRCm38)
26884453 Sklq16_m skull length QTL 16, 16 week (mouse) 11 3300000 72800000 Mouse 13208559 Wght10_m weight 10 (mouse) 11 4000000 89000000 Mouse 13208558 Lgth12_m body length 12 (mouse) 11 4000000 95000000 Mouse 1300905 Scc6_m colon tumor susceptibility 6 (mouse) Not determined 11 6930277 89128908 Mouse 1357859 Lvrq7_m liver weight QTL 7 (mouse) Not determined 11 12318637 118131898 Mouse 39128214 Lwq20_m liver weight QTL 20 (mouse) 11 12318637 118131898 Mouse 4141894 Nidd6k_m Nidd6 on KK-A (mouse) Not determined 19174204 97007000 Mouse 10412246 Dfs2_m dental fluorosis suseptibility 2 (mouse) Not determined 11 21857364 95990405 Mouse 13208569 Bmiq10_m body mass index QTL 10 (mouse) 11 36000000 85000000 Mouse 1301328 Mol4_m modifier of LPS-response 4 (mouse) Not determined 11 36391750 83590530 Mouse 4141853 Skmw17_m skeletal muscle weight 17 (mouse) Not determined 11 37190115 71190238 Mouse 10766457 Nwa3_m New Zealand White autoimmunity 3 (mouse) 11 38125289 72125383 Mouse 11532698 Sluc36a_m susceptibility to lung cancer 36a (mouse) 11 42365791 76365904 Mouse 11532699 Sluc36b_m susceptibility to lung cancer 36b (mouse) 11 42365791 76365904 Mouse 4142300 Ctrq3_m C. trachomatis resistance QTL 3 (mouse) Not determined 11 44739211 76963931 Mouse 4141367 Inf1_m acute ozone induced inflammation (mouse) Not determined 44739211 113167183 Mouse 4141000 Nidd3_m non-insulin-dependent diabetes mellitus 3 (mouse) Not determined 45151201 79151308 Mouse 1302021 Nidd1n_m non-insulin-dependent diabetes mellitus 1 in NSY (mouse) Not determined 11 45275046 80087498 Mouse 1357878 Mastr_m modifier of astrocytoma (mouse) Not determined 11 45817754 89927907 Mouse 1300765 Bbaa4_m B.burgdorferi-associated arthritis 4 (mouse) Not determined 11 46294341 80294436 Mouse 1301988 Bmd11_m bone mineral density 11 (mouse) Not determined 11 46428581 80428696 Mouse 1301830 Ssta4_m susceptibility to Salmonella typhimurium antigens 4 (mouse) Not determined 11 50187365 84187585 Mouse 13524840 Ppiq9a_m prepulse inhibition QTL 9a (mouse) 11 52603559 86603559 Mouse 1300774 Pgia7_m proteoglycan induced arthritis 7 (mouse) Not determined 11 53499762 87499911 Mouse 4141830 Pregq1_m pregnancy QTL 1 (mouse) Not determined 11 54235926 83842826 Mouse 4141875 Etax9_m ethanol induced ataxia 9 (mouse) Not determined 55394159 72319101 Mouse 4142121 Tmc1m2_m Tmc1 modifier 2 (mouse) Not determined 11 56973201 114267131 Mouse 1300664 Etohcta9_m ethanol conditioned taste aversion 9 (mouse) Not determined 11 57863834 91863932 Mouse 10053682 Eae45_m experimental allergic encephalomyelitis susceptibility 45 (mouse) Not determined 11 58599729 74863932 Mouse 1300924 Ity2_m immunity to S. typhimurium 2 (mouse) Not determined 1 58617204 87804412 Mouse 4141982 Skts-fp2_m skin tumor susceptibility in FVB and PWK 2 (mouse) Not determined 58828440 85175703 Mouse 1301987 Pid3_m prior incubation determinant 3 (mouse) Not determined 11 61795994 88808902 Mouse 1301319 Dautb4_m dopamine uptake transporter binding 4 (mouse) Not determined 11 62265179 96265327 Mouse 27226730 Tibmd1_m tibia midshaft diameter 1, 5 week (mouse) 11 62700000 109500000 Mouse 1301999 Lmr15_m leishmaniasis resistance 15 (mouse) Not determined 11 63428581 81939647 Mouse 10044004 Stzid3_m streptozotocin induced diabetes susceptibility 3 (mouse) Not determined 11 63428581 94173092 Mouse 11039501 Ltpr6a_m Leishmania tropica response 6a (mouse) 11 64939510 98939647 Mouse 11039502 Ltpr6b_m Leishmania tropica response 6b (mouse) 11 64939510 98939647 Mouse 11039515 Ltpr6_m Leishmania tropica response 6 (mouse) 11 64939510 98939647 Mouse 1301546 Pcir2_m periosteal circumference 2 (mouse) Not determined 11 66842594 100842826 Mouse 1357766 Si5lq6_m serum IGFBP-5 level QTL 6 (mouse) Not determined 11 66842594 100842826 Mouse 4141012 Femwf6_m femur work to failure 6 (mouse) Not determined 66842594 100842826 Mouse 1301833 Tbbmd5_m total body bone mineral density 5 (mouse) Not determined 11 66842594 100842826 Mouse 1300784 Prdt3_m prion disease incubation time 3 (mouse) Not determined 11 66842594 100842826 Mouse 1300628 Lgth6_m body length 6 (mouse) Not determined 11 66842594 100842826 Mouse 4142316 Ity2b_m immunity to S. typhimurium 2b (mouse) Not determined 11 67187365 79923086 Mouse 27226783 Tibl5_m tibia length 5, 5 week (mouse) 11 68300000 102000000 Mouse 36049778 Ars6_m antibody response to SARS-CoV 6, day 15, IgM (mouse) 11 69100000 72600000 Mouse 36049779 Ars7_m antibody response to SARS-CoV 7, day 29, IgG1 (mouse) 11 69100000 72600000 Mouse 36049784 Ars8_m antibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse) 11 69100000 72600000 Mouse 36049785 Ars9_m antibody response to SARS-CoV 9, day 29, IgM (mouse) 11 69100000 72600000 Mouse 36049786 Ars10_m antibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse) 11 69100000 72600000 Mouse 36049787 Ars11_m antibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse) 11 69100000 72600000 Mouse 36049788 Ars1_m antibody response to SARS-CoV 1, day 7, IgG1 (mouse) 11 69100000 72600000 Mouse 36049789 Ars2_m antibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse) 11 69100000 72600000 Mouse 36049790 Ars3_m antibody response to SARS-CoV 3, day 7, IgG2b (mouse) 11 69100000 72600000 Mouse 36049791 Ars4_m antibody response to SARS-CoV 4, day 7, IgG3 (mouse) 11 69100000 72600000 Mouse 36049792 Ars5_m antibody response to SARS-CoV 5, day 7, IgM (mouse) 11 69100000 72600000 Mouse 35673314 Ari2_m antibody response to influenza 2, day 10, IgG3 (mouse) 11 69100000 72600000 Mouse 1300651 Pcyts3_m plasmacytoma susceptibility 3 (mouse) Not determined 11 70800372 104800540 Mouse 1301681 Sle13_m systematic lupus erythematosus susceptibility 13 (mouse) Not determined 11 70800372 104800540 Mouse 1558812 Rafar_m retinoic acid induced forelimb autopod reduction (mouse) Not determined 11 70800372 104800540 Mouse 4141339 Nilac2_m nicotine induced locomotor activity 2 (mouse) Not determined 11 70800372 104800540 Mouse
