NLRP3 (NLR family pyrin domain containing 3) - Rat Genome Database

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Gene: NLRP3 (NLR family pyrin domain containing 3) Homo sapiens
Analyze
Symbol: NLRP3
Name: NLR family pyrin domain containing 3
RGD ID: 1318014
HGNC Page HGNC
Description: Exhibits identical protein binding activity. Involved in several processes, including negative regulation of NIK/NF-kappaB signaling; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; and regulation of gene expression. Localizes to Golgi membrane and NLRP3 inflammasome complex. Implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AGTAVPRL; AII; AII/AVP; AII/AVP receptor-like; angiotensin/vasopressin receptor AII/AVP-like; AVP; C1orf7; caterpiller protein 1.1; CIAS1; CLR1.1; cold autoinflammatory syndrome 1; cryopyrin; cryopyrin, NACHT, LRR and PYD domains - containing protein 3; deafness, autosomal dominant 34; DFNA34; FCAS; FCAS1; FCU; FLJ95925; KEFH; MWS; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3; NACHT, LRR and PYD containing protein 3; NACHT, LRR and PYD domains-containing protein 3; NALP3; NLR family, pyrin domain containing 3; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3; PYPAF1; PYRIN-containing APAF1-like protein 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: NLRP3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1247,416,156 - 247,449,108 (+)EnsemblGRCh38hg38GRCh38
GRCh381247,416,163 - 247,448,823 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371247,579,475 - 247,612,119 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361245,646,098 - 245,679,033 (+)NCBINCBI36hg18NCBI36
Build 341243,907,391 - 243,938,445NCBI
Celera1220,878,780 - 220,911,159 (+)NCBI
Cytogenetic Map1q44NCBI
HuRef1217,973,841 - 218,006,798 (+)NCBIHuRef
CHM1_11248,851,104 - 248,884,745 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,4-phenylenediamine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,5-hexanedione  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
3-mercaptopropanoic acid  (ISO)
3-methyladenine  (EXP)
4-hydroxynon-2-enal  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
4-phenylbutyric acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
7-ketocholesterol  (ISO)
acetamide  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (EXP)
aconitine  (ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
allicin  (ISO)
allopurinol  (EXP,ISO)
aluminium hydroxide  (ISO)
aluminium sulfate (anhydrous)  (ISO)
amitriptyline  (ISO)
amphetamine  (ISO)
amphibole asbestos  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antirheumatic drug  (EXP)
apocynin  (EXP)
aripiprazole  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
asbestos  (EXP)
astragaloside IV  (ISO)
ATP  (EXP,ISO)
atropine  (EXP)
azathioprine  (ISO)
bafilomycin A1  (EXP)
baicalin  (ISO)
benzo[a]pyrene  (EXP)
benzo[e]pyrene  (EXP)
Bergenin  (ISO)
bisphenol A  (ISO)
bortezomib  (EXP)
buta-1,3-diene  (ISO)
butanal  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
celastrol  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
cisplatin  (ISO)
cobalt atom  (EXP)
crocidolite asbestos  (EXP,ISO)
cycloheximide  (EXP)
D-glucose  (EXP,ISO)
dexamethasone  (ISO)
dexmedetomidine  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP,ISO)
dicloxacillin  (ISO)
diethyldithiocarbamic acid  (ISO)
dihydroartemisinin  (ISO)
dimethyldithiocarbamate  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP)
elemental selenium  (EXP)
endosulfan  (EXP)
ergosterol  (ISO)
eriodictyol  (ISO)
Erionite  (EXP)
ethanol  (EXP,ISO)
flutamide  (EXP,ISO)
formaldehyde  (EXP)
fructose  (ISO)
furan  (ISO)
furosemide  (ISO)
Fusaric acid  (EXP)
glucose  (EXP,ISO)
glyburide  (ISO)
glyphosate  (ISO)
guggulsterone  (ISO)
hexadecanoic acid  (ISO)
HU-308  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
iohexol  (ISO)
ketoconazole  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
magnesium dihydroxide  (ISO)
maneb  (ISO)
mangiferin  (EXP)
mebendazole  (EXP)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methimazole  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP,ISO)
nigericin  (EXP)
NMN zwitterion  (ISO)
obeticholic acid  (ISO)
omeprazole  (ISO)
ozone  (EXP,ISO)
Palbinone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parthenolide  (ISO)
pentanal  (EXP)
permethrin  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosgene  (ISO)
procyanidin B2  (ISO)
propanal  (EXP)
Pyridostigmine bromide  (ISO)
quercetin  (EXP,ISO)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
rutin  (ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salidroside  (ISO)
SB 203580  (EXP,ISO)
selenium atom  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
streptozocin  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
tamoxifen  (EXP)
taurine  (EXP,ISO)
tauroursodeoxycholic acid  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetramethylpyrazine  (ISO)
thapsigargin  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
Tungsten carbide  (EXP)
vinclozolin  (ISO)
XL147  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
acute inflammatory response  (ISO)
apoptotic process  (NAS)
cellular response to lipopolysaccharide  (IDA,IMP)
cellular response to peptidoglycan  (ISO)
defense response  (TAS)
defense response to Gram-positive bacterium  (ISO)
defense response to virus  (ISO)
detection of biotic stimulus  (TAS)
inflammatory response  (IMP)
innate immune response  (IEA)
leukocyte migration involved in inflammatory response  (IEA,ISO)
negative regulation of acute inflammatory response  (IMP)
negative regulation of inflammatory response  (IMP)
negative regulation of interleukin-1 beta production  (IMP)
negative regulation of NF-kappaB transcription factor activity  (IDA)
negative regulation of NIK/NF-kappaB signaling  (IBA,IDA)
NLRP3 inflammasome complex assembly  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IBA,IDA)
positive regulation of cytokine production involved in immune response  (ISO)
positive regulation of interleukin-1 beta production  (IDA,IMP,ISO)
positive regulation of interleukin-13 production  (ISO)
positive regulation of interleukin-4 production  (ISS)
positive regulation of interleukin-5 production  (ISO)
positive regulation of NF-kappaB transcription factor activity  (IDA,IPI)
positive regulation of T-helper 17 cell differentiation  (ISO)
positive regulation of T-helper 2 cell cytokine production  (ISS)
positive regulation of T-helper 2 cell differentiation  (ISS)
positive regulation of transcription by RNA polymerase II  (ISS)
positive regulation of type 2 immune response  (ISS)
protein deubiquitination  (TAS)
purinergic nucleotide receptor signaling pathway  (TAS)
regulation of inflammatory response  (ISO)
response to ethanol  (IEA,ISO)
response to organic cyclic compound  (IEA,ISO)
signal transduction  (NAS)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abdominal pain  (IAGP)
Abnormal palate morphology  (IAGP)
Abnormal thrombocyte morphology  (IAGP)
Abnormality of neutrophils  (IAGP)
Abnormality of the genital system  (IAGP)
Abnormality of the nose  (IAGP)
Abnormality of the voice  (IAGP)
Anemia  (IAGP)
Aphthous ulcer  (IAGP)
Arthralgia  (IAGP)
Arthritis  (IAGP)
Autosomal dominant inheritance  (IAGP)
Blindness  (IAGP)
Blurred vision  (IAGP)
Brachydactyly  (IAGP)
Broad foot  (IAGP)
Camptodactyly of finger  (IAGP)
Childhood onset  (IAGP)
Chills  (IAGP)
Chronic fatigue  (IAGP)
Clubbing of fingers  (IAGP)
Conjunctival hyperemia  (IAGP)
Conjunctivitis  (IAGP)
Cranial nerve paralysis  (IAGP)
Dehydration  (IAGP)
Delayed closure of the anterior fontanelle  (IAGP)
Delayed puberty  (IAGP)
Dysesthesia  (IAGP)
Edema  (IAGP)
EEG abnormality  (IAGP)
Elevated C-reactive protein level  (IAGP)
Elevated erythrocyte sedimentation rate  (IAGP)
Eosinophilia  (IAGP)
Epiphora  (IAGP)
Episcleritis  (IAGP)
Erythema  (IAGP)
Fatigue  (IAGP)
Fever  (IAGP)
Frontal bossing  (IAGP)
Glaucoma  (IAGP)
Global developmental delay  (IAGP)
Growth delay  (IAGP)
Headache  (IAGP)
Hepatomegaly  (IAGP)
Hepatosplenomegaly  (IAGP)
Hernia of the abdominal wall  (IAGP)
Hyperhidrosis  (IAGP)
Ichthyosis  (IAGP)
Increased intracranial pressure  (IAGP)
Infantile onset  (IAGP)
Intellectual disability  (IAGP)
Joint dislocation  (IAGP)
Juvenile onset  (IAGP)
Keratitis  (IAGP)
Leukocytosis  (IAGP)
Lymphadenopathy  (IAGP)
Lymphedema  (IAGP)
Macrocephaly  (IAGP)
Maculopapular exanthema  (IAGP)
Meningitis  (IAGP)
Migraine  (IAGP)
Myalgia  (IAGP)
Nausea and vomiting  (IAGP)
Neonatal onset  (IAGP)
Nephropathy  (IAGP)
Nephrotic syndrome  (IAGP)
Opacification of the corneal stroma  (IAGP)
Optic atrophy  (IAGP)
Papilledema  (IAGP)
Papule  (IAGP)
Parathyroid carcinoma  (IAGP)
Patellar overgrowth  (IAGP)
Periodic fever  (IAGP)
Pes cavus  (IAGP)
Photophobia  (IAGP)
Polyarticular arthritis  (IAGP)
Polydipsia  (IAGP)
Premature birth  (IAGP)
Progressive sensorineural hearing impairment  (IAGP)
Proptosis  (IAGP)
Pruritus  (IAGP)
Pseudopapilledema  (IAGP)
Purpura  (IAGP)
Recurrent aphthous stomatitis  (IAGP)
Recurrent fever  (IAGP)
Reduced bone mineral density  (IAGP)
Renal amyloidosis  (IAGP)
Renal insufficiency  (IAGP)
Restrictive ventilatory defect  (IAGP)
Retrobulbar optic neuritis  (IAGP)
Seizure  (IAGP)
Sensorineural hearing impairment  (IAGP)
Short stature  (IAGP)
Skeletal dysplasia  (IAGP)
Skin rash  (IAGP)
Slowly progressive  (IAGP)
Splenomegaly  (IAGP)
Urticaria  (IAGP)
Uveitis  (IAGP)
Variable expressivity  (IAGP)
Vasculitis  (IAGP)
References

Additional References at PubMed
PMID:9653160   PMID:10741953   PMID:11042152   PMID:11786556   PMID:11967258   PMID:11992256   PMID:12032915   PMID:12093792   PMID:12355493   PMID:12477932   PMID:12483741   PMID:12522564  
PMID:12563287   PMID:12615073   PMID:12673085   PMID:12766759   PMID:14630794   PMID:14662828   PMID:15020601   PMID:15030775   PMID:15071491   PMID:15107016   PMID:15334500   PMID:15593220  
PMID:15817483   PMID:15967716   PMID:16037825   PMID:16234278   PMID:16344560   PMID:16531551   PMID:16642435   PMID:16710414   PMID:16868559   PMID:17046979   PMID:17164343   PMID:17164409  
PMID:17178985   PMID:17213252   PMID:17284928   PMID:17393462   PMID:17435760   PMID:17592301   PMID:17599094   PMID:17620097   PMID:17697637   PMID:17763411   PMID:17907925   PMID:18005730  
PMID:18063752   PMID:18080732   PMID:18084703   PMID:18174231   PMID:18175851   PMID:18189199   PMID:18263599   PMID:18311798   PMID:18576390   PMID:18719602   PMID:18772453   PMID:19001869  
PMID:19058789   PMID:19098911   PMID:19120479   PMID:19120481   PMID:19158675   PMID:19201894   PMID:19223160   PMID:19254587   PMID:19319132   PMID:19337385   PMID:19364881   PMID:19414800  
PMID:19454352   PMID:19570822   PMID:19579027   PMID:19648107   PMID:19767079   PMID:19784369   PMID:19805629   PMID:19811501   PMID:19824913   PMID:19826485   PMID:19890791   PMID:19913121  
PMID:20002790   PMID:20008285   PMID:20011700   PMID:20031576   PMID:20038581   PMID:20060594   PMID:20131254   PMID:20131270   PMID:20135584   PMID:20148899   PMID:20179743   PMID:20182451  
PMID:20237496   PMID:20368800   PMID:20370570   PMID:20384614   PMID:20401456   PMID:20401526   PMID:20403135   PMID:20407038   PMID:20421639   PMID:20502346   PMID:20506209   PMID:20628086  
PMID:20668705   PMID:20688930   PMID:20800603   PMID:20808838   PMID:20884650   PMID:20962258   PMID:20980503   PMID:21035374   PMID:21051542   PMID:21058222   PMID:21109514   PMID:21124315  
PMID:21124859   PMID:21217695   PMID:21241317   PMID:21245836   PMID:21300955   PMID:21315400   PMID:21342182   PMID:21394384   PMID:21421008   PMID:21451572   PMID:21508263   PMID:21550598  
PMID:21560198   PMID:21566220   PMID:21621776   PMID:21637346   PMID:21646297   PMID:21873635   PMID:21876553   PMID:21880711   PMID:21930705   PMID:21940629   PMID:21940680   PMID:21971358  
PMID:21978001   PMID:21994456   PMID:22102247   PMID:22112657   PMID:22128899   PMID:22146561   PMID:22227418   PMID:22227487   PMID:22276187   PMID:22295065   PMID:22325453   PMID:22403613  
PMID:22461501   PMID:22490866   PMID:22497426   PMID:22503597   PMID:22522430   PMID:22524199   PMID:22529966   PMID:22541070   PMID:22558425   PMID:22608495   PMID:22698681   PMID:22723549  
PMID:22768094   PMID:22796220   PMID:22801494   PMID:22843550   PMID:22904305   PMID:22933232   PMID:22933241   PMID:22935299   PMID:22948162   PMID:22981536   PMID:22984081   PMID:22984082  
PMID:22997256   PMID:23015306   PMID:23066025   PMID:23086037   PMID:23110140   PMID:23171454   PMID:23206693   PMID:23209696   PMID:23211828   PMID:23221073   PMID:23229815   PMID:23254930  
PMID:23264657   PMID:23271661   PMID:23280543   PMID:23315075   PMID:23375846   PMID:23382313   PMID:23399110   PMID:23421920   PMID:23427152   PMID:23430110   PMID:23434541   PMID:23440695  
PMID:23453445   PMID:23462287   PMID:23505242   PMID:23530046   PMID:23549611   PMID:23563199   PMID:23567555   PMID:23582325   PMID:23588528   PMID:23614732   PMID:23633957   PMID:23686720  
PMID:23737748   PMID:23738518   PMID:23809162   PMID:23815151   PMID:23825667   PMID:23838163   PMID:23840644   PMID:23843215   PMID:23871209   PMID:23884315   PMID:23886272   PMID:23911403  
PMID:23937860   PMID:23954133   PMID:23969696   PMID:23973727   PMID:23977231   PMID:23980097   PMID:24008734   PMID:24012762   PMID:24013717   PMID:24041971   PMID:24048902   PMID:24098386  
PMID:24118105   PMID:24121974   PMID:24135410   PMID:24136334   PMID:24144430   PMID:24144834   PMID:24158569   PMID:24158955   PMID:24166187   PMID:24223129   PMID:24244322   PMID:24295199  
PMID:24307525   PMID:24326009   PMID:24329484   PMID:24334646   PMID:24361386   PMID:24386947   PMID:24453977   PMID:24456929   PMID:24470197   PMID:24472059   PMID:24478101   PMID:24501247  
PMID:24517500   PMID:24531343   PMID:24572449   PMID:24583910   PMID:24630722   PMID:24687021   PMID:24692555   PMID:24708999   PMID:24776598   PMID:24820890   PMID:24840700   PMID:24846290  
PMID:24849809   PMID:24861026   PMID:24894535   PMID:24939850   PMID:24965773   PMID:24988285   PMID:24990442   PMID:25001390   PMID:25011057   PMID:25048991   PMID:25172487   PMID:25172489  
PMID:25175736   PMID:25188917   PMID:25193031   PMID:25202020   PMID:25231464   PMID:25239704   PMID:25267545   PMID:25271165   PMID:25281528   PMID:25284686   PMID:25288801   PMID:25297810  
PMID:25311115   PMID:25355909   PMID:25356867   PMID:25406505   PMID:25411003   PMID:25417688   PMID:25438464   PMID:25461402   PMID:25538194   PMID:25580516   PMID:25581126   PMID:25586466  
PMID:25589411   PMID:25593314   PMID:25594175   PMID:25625584   PMID:25639477   PMID:25644004   PMID:25648527   PMID:25651569   PMID:25654762   PMID:25655831   PMID:25684031   PMID:25686493  
PMID:25730877   PMID:25732894   PMID:25739168   PMID:25761061   PMID:25761252   PMID:25783493   PMID:25798846   PMID:25813065   PMID:25834832   PMID:25847326   PMID:25920454   PMID:25938942  
PMID:25939513   PMID:25946654   PMID:25955828   PMID:25962072   PMID:25993444   PMID:26006022   PMID:26027935   PMID:26033552   PMID:26037399   PMID:26037928   PMID:26053021   PMID:26059659  
PMID:26074413   PMID:26075098   PMID:26102024   PMID:26114647   PMID:26116704   PMID:26146985   PMID:26160272   PMID:26173988   PMID:26174085   PMID:26178285   PMID:26200799   PMID:26238426  
PMID:26253076   PMID:26258904   PMID:26272943   PMID:26273672   PMID:26282945   PMID:26290166   PMID:26306997   PMID:26316056   PMID:26332984   PMID:26344197   PMID:26347139   PMID:26381780  
PMID:26385789   PMID:26398903   PMID:26427394   PMID:26431797   PMID:26435000   PMID:26457439   PMID:26471297   PMID:26496436   PMID:26496610   PMID:26511096   PMID:26515928   PMID:26529255  
PMID:26535712   PMID:26540403   PMID:26574023   PMID:26662437   PMID:26689701   PMID:26722603   PMID:26743485   PMID:26760997   PMID:26782387   PMID:26782741   PMID:26814970   PMID:26854620  
PMID:26865721   PMID:26902715   PMID:26939933   PMID:26951262   PMID:26968633   PMID:26972847   PMID:26987611   PMID:27014913   PMID:27036377   PMID:27043286   PMID:27043625   PMID:27045344  
PMID:27060062   PMID:27086574   PMID:27093923   PMID:27098789   PMID:27101784   PMID:27103438   PMID:27110561   PMID:27146654   PMID:27160314   PMID:27174093   PMID:27207962   PMID:27214553  
PMID:27221966   PMID:27250627   PMID:27297387   PMID:27308893   PMID:27313051   PMID:27366746   PMID:27405925   PMID:27417584   PMID:27431477   PMID:27432880   PMID:27446858   PMID:27446957  
PMID:27447246   PMID:27455015   PMID:27490927   PMID:27548431   PMID:27563009   PMID:27600251   PMID:27614764   PMID:27626170   PMID:27632566   PMID:27669650   PMID:27721494   PMID:27737891  
PMID:27750030   PMID:27779191   PMID:27788256   PMID:27796668   PMID:27819323   PMID:27820602   PMID:27826011   PMID:27833015   PMID:27912077   PMID:27929086   PMID:27942750   PMID:27943647  
PMID:27965388   PMID:27965898   PMID:27966619   PMID:27967213   PMID:27974218   PMID:28004443   PMID:28011505   PMID:28028683   PMID:28030552   PMID:28031477   PMID:28034752   PMID:28052869  
PMID:28057759   PMID:28064010   PMID:28083517   PMID:28084571   PMID:28094437   PMID:28116820   PMID:28153878   PMID:28167279   PMID:28185410   PMID:28197772   PMID:28224704   PMID:28229991  
PMID:28235036   PMID:28302726   PMID:28326454   PMID:28334721   PMID:28345767   PMID:28403163   PMID:28420787   PMID:28427559   PMID:28430665   PMID:28442553   PMID:28456882   PMID:28461245  
PMID:28470940   PMID:28487310   PMID:28503575   PMID:28523573   PMID:28544564   PMID:28584053   PMID:28588189   PMID:28591554   PMID:28606793   PMID:28629999   PMID:28631886   PMID:28634744  
PMID:28637493   PMID:28692792   PMID:28798291   PMID:28799242   PMID:28847925   PMID:28849014   PMID:28865486   PMID:28904126   PMID:28915449   PMID:28961497   PMID:28984607   PMID:29021376  
PMID:29024797   PMID:29033128   PMID:29059152   PMID:29072703   PMID:29097227   PMID:29097263   PMID:29102545   PMID:29117789   PMID:29122594   PMID:29144508   PMID:29145789   PMID:29148409  
PMID:29150951   PMID:29176764   PMID:29196167   PMID:29203171   PMID:29207030   PMID:29214547   PMID:29230505   PMID:29255148   PMID:29256638   PMID:29258239   PMID:29258746   PMID:29259175  
PMID:29270247   PMID:29279328   PMID:29285715   PMID:29291748   PMID:29319163   PMID:29339210   PMID:29345311   PMID:29359681   PMID:29366613   PMID:29385859   PMID:29393464   PMID:29408806  
PMID:29415184   PMID:29430721   PMID:29430761   PMID:29450537   PMID:29483915   PMID:29490278   PMID:29528779   PMID:29545514   PMID:29573224   PMID:29588192   PMID:29625905   PMID:29626160  
PMID:29655789   PMID:29656319   PMID:29662840   PMID:29665074   PMID:29680907   PMID:29683202   PMID:29712950   PMID:29716544   PMID:29723525   PMID:29723617   PMID:29735414   PMID:29743981  
PMID:29767259   PMID:29769161   PMID:29783158   PMID:29803661   PMID:29807832   PMID:29850521   PMID:29850543   PMID:29850631   PMID:29888470   PMID:29891998   PMID:29906464   PMID:29907661  
PMID:29907905   PMID:29941940   PMID:29946988   PMID:29953588   PMID:29972041   PMID:29986838   PMID:30014749   PMID:30015880   PMID:30021884   PMID:30021903   PMID:30069026   PMID:30090015  
PMID:30119891   PMID:30157429   PMID:30182366   PMID:30198786   PMID:30206189   PMID:30236770   PMID:30236988   PMID:30248487   PMID:30264444   PMID:30277570   PMID:30280383   PMID:30316511  
PMID:30347231   PMID:30368901   PMID:30389501   PMID:30392787   PMID:30415294   PMID:30418111   PMID:30487600   PMID:30489008   PMID:30539655   PMID:30575805   PMID:30582517   PMID:30583612  
PMID:30591217   PMID:30592131   PMID:30596757   PMID:30612879   PMID:30616678   PMID:30619282   PMID:30628671   PMID:30653357   PMID:30657189   PMID:30658148   PMID:30658261   PMID:30666624  
PMID:30728751   PMID:30747211   PMID:30747229   PMID:30761102   PMID:30771382   PMID:30776150   PMID:30787184   PMID:30802690   PMID:30804327   PMID:30816317   PMID:30833078   PMID:30869997  
PMID:30894604   PMID:30911280   PMID:30927257   PMID:30940045   PMID:30940293   PMID:30944389   PMID:30945288   PMID:30953761   PMID:30980521   PMID:31017673   PMID:31036561   PMID:31102698  
PMID:31113917   PMID:31135083   PMID:31141130   PMID:31153046   PMID:31167564   PMID:31186034   PMID:31189953   PMID:31214158   PMID:31221993   PMID:31231549   PMID:31244842   PMID:31257469  
PMID:31311035   PMID:31324763   PMID:31351424   PMID:31359456   PMID:31366948   PMID:31417078   PMID:31430634   PMID:31453709   PMID:31467293   PMID:31471397   PMID:31485604   PMID:31513803  
PMID:31515707   PMID:31529732   PMID:31531346   PMID:31532390   PMID:31545233   PMID:31553908   PMID:31557327   PMID:31577945   PMID:31587010   PMID:31596526   PMID:31611559   PMID:31639433  
PMID:31642433   PMID:31651575   PMID:31652453   PMID:31663353   PMID:31669192   PMID:31703838   PMID:31734269   PMID:31740004   PMID:31757663   PMID:31759058   PMID:31762063   PMID:31770592  
PMID:31787755   PMID:31796125   PMID:31799681   PMID:31804457   PMID:31809715   PMID:31816408   PMID:31838136   PMID:31860730   PMID:31866999   PMID:31870428   PMID:31895698   PMID:31901930  
PMID:31902237   PMID:31914638   PMID:31914643   PMID:31915018   PMID:31937421   PMID:31976565   PMID:31978095   PMID:31988111   PMID:31997770   PMID:31998284   PMID:31999304   PMID:32003754  
PMID:32030415   PMID:32059980   PMID:32135277   PMID:32169738   PMID:32185238   PMID:32188057   PMID:32234474   PMID:32289583   PMID:32298723   PMID:32313131   PMID:32323100   PMID:32323732  
PMID:32323780   PMID:32385301   PMID:32386456   PMID:32396255   PMID:32420343   PMID:32456012   PMID:32475381   PMID:32507974   PMID:32516127   PMID:32545355   PMID:32545788   PMID:32560261  
PMID:32592441   PMID:32689633   PMID:32691370   PMID:32707731   PMID:32751171   PMID:32782149   PMID:32807449   PMID:32814053   PMID:32817626   PMID:32843625   PMID:32867310   PMID:32871918  
PMID:32961144   PMID:32971400   PMID:33044555   PMID:33092247   PMID:33111436   PMID:33181254   PMID:33429941   PMID:33435142   PMID:33454007   PMID:33683342  


Genomics

Comparative Map Data
NLRP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1247,416,156 - 247,449,108 (+)EnsemblGRCh38hg38GRCh38
GRCh381247,416,163 - 247,448,823 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371247,579,475 - 247,612,119 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361245,646,098 - 245,679,033 (+)NCBINCBI36hg18NCBI36
Build 341243,907,391 - 243,938,445NCBI
Celera1220,878,780 - 220,911,159 (+)NCBI
Cytogenetic Map1q44NCBI
HuRef1217,973,841 - 218,006,798 (+)NCBIHuRef
CHM1_11248,851,104 - 248,884,745 (+)NCBICHM1_1
Nlrp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,432,395 - 59,457,781 (+)NCBIGRCm39mm39
GRCm39 Ensembl1159,432,394 - 59,457,782 (+)Ensembl
GRCm381159,541,569 - 59,566,955 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,541,568 - 59,566,956 (+)EnsemblGRCm38mm10GRCm38
MGSCv371159,356,188 - 59,380,458 (+)NCBIGRCm37mm9NCBIm37
MGSCv361160,078,786 - 60,103,056 (+)NCBImm8
MGSCv361159,358,881 - 59,383,151 (+)NCBImm8
Cytogenetic Map11B1.3NCBI
Nlrp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21044,326,770 - 44,353,814 (+)NCBI
Rnor_6.0 Ensembl1045,893,018 - 45,918,254 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01045,884,324 - 45,918,290 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01045,648,191 - 45,674,617 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,850,224 - 45,874,533 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11045,864,282 - 45,887,837 (+)NCBI
Celera1043,590,413 - 43,614,602 (+)NCBICelera
Cytogenetic Map10q22NCBI
Nlrp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955581597,667 - 617,410 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955581597,952 - 616,903 (+)NCBIChiLan1.0ChiLan1.0
NLRP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11228,505,147 - 228,537,216 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1228,505,147 - 228,537,216 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01223,052,307 - 223,084,736 (+)NCBIMhudiblu_PPA_v0panPan3
NLRP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.18251,776 - 313,290 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl8253,407 - 313,059 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha8277,639 - 339,097 (+)NCBI
ROS_Cfam_1.08299,639 - 361,123 (+)NCBI
UMICH_Zoey_3.18242,540 - 300,444 (+)NCBI
UNSW_CanFamBas_1.08204,531 - 262,443 (+)NCBI
UU_Cfam_GSD_1.08337,026 - 389,302 (+)NCBI
Nlrp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721388,366,531 - 88,390,960 (+)NCBI
SpeTri2.0NW_004936864709,693 - 732,119 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLRP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl256,892,242 - 56,977,234 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1256,892,241 - 56,977,412 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2257,789,084 - 57,873,272 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NLRP3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12584,431,436 - 84,463,387 (+)NCBI
ChlSab1.1 Ensembl2584,434,527 - 84,463,249 (+)Ensembl
Nlrp3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624937564,191 - 584,470 (-)NCBI

Position Markers
D1S2215  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371247,602,189 - 247,602,424UniSTSGRCh37
Build 361245,668,812 - 245,669,047RGDNCBI36
Celera1220,901,365 - 220,901,604RGD
Cytogenetic Map1q44UniSTS
HuRef1217,996,708 - 217,996,951UniSTS
Marshfield Genetic Map1285.74UniSTS
Marshfield Genetic Map1285.74RGD
deCODE Assembly Map1273.18UniSTS
SHGC-76649  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371247,612,047 - 247,612,192UniSTSGRCh37
Build 361245,678,670 - 245,678,815RGDNCBI36
Celera1220,910,795 - 220,910,941RGD
Cytogenetic Map1q44UniSTS
HuRef1218,006,434 - 218,006,580UniSTS
TNG Radiation Hybrid Map1125615.0UniSTS
GeneMap99-GB4 RH Map1767.95UniSTS
NCBI RH Map12001.5UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1690
Count of miRNA genes:532
Interacting mature miRNAs:583
Transcripts:ENST00000336119, ENST00000348069, ENST00000366496, ENST00000366497, ENST00000391827, ENST00000391828, ENST00000474792, ENST00000532083
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 7 649 4 1 689 1 26 5 16 4 33 169 2 83 16
Low 1941 1706 1257 327 855 198 2779 1010 3164 283 1065 1172 136 1106 1779 4
Below cutoff 443 631 448 280 311 252 1494 1167 524 122 325 204 34 1 15 992 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_007509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001079821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001127461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001127462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001243133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_183395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011544048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017000181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017000182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024452862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024452874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB120959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB120960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB120961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB120962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB208891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC104335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF054176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF410477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF418985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF420469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF427617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF468522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH011140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL601856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL606804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY092033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY422168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC117211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA244290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG557564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK697677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000336119   ⟹   ENSP00000337383
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1247,418,049 - 247,448,817 (+)Ensembl
RefSeq Acc Id: ENST00000348069   ⟹   ENSP00000294752
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1247,418,049 - 247,448,817 (+)Ensembl
RefSeq Acc Id: ENST00000366496   ⟹   ENSP00000355452
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1247,418,052 - 247,448,817 (+)Ensembl
RefSeq Acc Id: ENST00000366497   ⟹   ENSP00000355453
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1247,416,156 - 247,449,102 (+)Ensembl
RefSeq Acc Id: ENST00000391827   ⟹   ENSP00000375703
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1247,418,795 - 247,448,504 (+)Ensembl
RefSeq Acc Id: ENST00000391828   ⟹   ENSP00000375704
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1247,416,156 - 247,449,108 (+)Ensembl
RefSeq Acc Id: ENST00000474792   ⟹   ENSP00000493937
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1247,418,620 - 247,425,792 (+)Ensembl
RefSeq Acc Id: ENST00000532083
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1247,443,907 - 247,448,576 (+)Ensembl
RefSeq Acc Id: ENST00000642259   ⟹   ENSP00000494332
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1247,418,936 - 247,448,993 (+)Ensembl
RefSeq Acc Id: ENST00000643234   ⟹   ENSP00000493674
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1247,418,730 - 247,448,595 (+)Ensembl
RefSeq Acc Id: NM_001079821   ⟹   NP_001073289
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381247,416,173 - 247,448,817 (+)NCBI
GRCh371247,579,247 - 247,612,410 (+)NCBI
Build 361245,646,098 - 245,679,033 (+)NCBI Archive
HuRef1217,973,841 - 218,006,798 (+)ENTREZGENE
CHM1_11248,851,104 - 248,884,745 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001127461   ⟹   NP_001120933
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381247,416,173 - 247,448,817 (+)NCBI
GRCh371247,579,247 - 247,612,410 (+)NCBI
HuRef1217,973,841 - 218,006,798 (+)ENTREZGENE
CHM1_11248,851,104 - 248,884,745 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001127462   ⟹   NP_001120934
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381247,416,173 - 247,448,817 (+)NCBI
GRCh371247,579,247 - 247,612,410 (+)NCBI
HuRef1217,973,841 - 218,006,798 (+)ENTREZGENE
CHM1_11248,852,934 - 248,884,745 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001243133   ⟹   NP_001230062
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381247,416,173 - 247,448,817 (+)NCBI
GRCh371247,579,247 - 247,612,410 (+)NCBI
HuRef1217,973,841 - 218,006,798 (+)NCBI
CHM1_11248,852,934 - 248,884,745 (+)NCBI
Sequence:
RefSeq Acc Id: NM_004895   ⟹   NP_004886
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381247,416,173 - 247,448,817 (+)NCBI
GRCh371247,579,247 - 247,612,410 (+)NCBI
Build 361245,647,974 - 245,679,033 (+)NCBI Archive
HuRef1217,973,841 - 218,006,798 (+)ENTREZGENE
CHM1_11248,852,934 - 248,884,745 (+)NCBI
Sequence:
RefSeq Acc Id: NM_183395   ⟹   NP_899632
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381247,416,173 - 247,448,817 (+)NCBI
GRCh371247,579,247 - 247,612,410 (+)NCBI
Build 361245,647,974 - 245,679,033 (+)NCBI Archive
HuRef1217,973,841 - 218,006,798 (+)ENTREZGENE
CHM1_11248,852,934 - 248,884,745 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011544048   ⟹   XP_011542350
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381247,416,173 - 247,448,823 (+)NCBI
Sequence: