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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628637
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pycard
Name: PYD and CARD domain containing
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pycardincreases expressionEXP 6480464CTDCadmium Chloride results in increased expression of PYCARD mRNAPMID:25993096
Pycardmultiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PYCARD mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PYCARD protein; galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PYCARD protein]PMID:34510229 PMID:35384154
Pycardincreases expressionISOPYCARD (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of PYCARD mRNAPMID:30796460
Pycardmultiple interactionsISOPycard (Mus musculus)6480464CTD4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of PYCARD mRNA]PMID:30796460
Pycardmultiple interactionsISOPYCARD (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PYCARD mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PYCARD protein; NLRP3 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PYCARD protein]; SIRT1 protein inhibits the reaction [Cadmium Chloride results in increased expression of PYCARD mRNA]; STF 083010 inhibits the reaction [Cadmium Chloride results in increased expression of PYCARD mRNA]; XBP1 protein affects the reaction [Cadmium Chloride results in increased expression of PYCARD mRNA]PMID:30796460 PMID:34510229
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