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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628637
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pycard
Name: PYD and CARD domain containing
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pycardincreases expressionISOPycard (Mus musculus)6480464CTDCisplatin results in increased expression of PYCARD proteinPMID:25308879 PMID:34423507 PMID:36341876
Pycardincreases expressionISOPYCARD (Homo sapiens)6480464CTDCisplatin results in increased expression of PYCARD mRNA; Cisplatin results in increased expression of PYCARD proteinPMID:27392435 PMID:34423507
Pycardmultiple interactionsISOPycard (Mus musculus)6480464CTD3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Cisplatin results in increased expression of PYCARD protein]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of PYCARD protein]PMID:25308879 PMID:34423507
Pycardmultiple interactionsISOPYCARD (Homo sapiens)6480464CTD3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of PYCARD protein]]; [Cisplatin co-treated with jinfukang] results in increased expression of PYCARD mRNA; ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of PYCARD protein]PMID:27392435 PMID:34423507
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