XIAP (X-linked inhibitor of apoptosis) - Rat Genome Database

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Gene: XIAP (X-linked inhibitor of apoptosis) Canis lupus familiaris
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Symbol: XIAP
Name: X-linked inhibitor of apoptosis
RGD ID: 12309295
Description: ENCODES a protein that exhibits protease binding (ortholog); scaffold protein binding (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); negative regulation of apoptotic process (ortholog); negative regulation of neuron apoptotic process (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; intrinsic apoptotic pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH adrenocortical carcinoma (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); autistic disorder (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog); protein-containing complex (ortholog); INTERACTS WITH doxorubicin
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: baculoviral IAP repeat-containing 4; baculoviral IAP-repeat containing protein 4; BIRC4; E3 ubiquitin-protein ligase XIAP; X-linked inhibitor of apoptosis protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X95,300,234 - 95,356,103 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX95,331,827 - 95,351,582 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX81,399,414 - 81,419,171 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X97,072,115 - 97,127,995 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX97,072,142 - 97,127,986 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X94,548,275 - 94,568,035 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X96,304,355 - 96,324,070 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X96,093,813 - 96,113,573 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
doxorubicin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
XIAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X95,300,234 - 95,356,103 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX95,331,827 - 95,351,582 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX81,399,414 - 81,419,171 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X97,072,115 - 97,127,995 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX97,072,142 - 97,127,986 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X94,548,275 - 94,568,035 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X96,304,355 - 96,324,070 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X96,093,813 - 96,113,573 (+)NCBIUU_Cfam_GSD_1.0
XIAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X123,859,708 - 123,913,972 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX123,859,712 - 123,913,972 (+)EnsemblGRCh38hg38GRCh38
GRCh37X122,993,558 - 123,047,822 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X122,821,729 - 122,875,503 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X122,719,582 - 122,773,357NCBI
CeleraX123,378,893 - 123,432,624 (+)NCBICelera
Cytogenetic MapXq25NCBI
HuRefX112,377,835 - 112,430,903 (+)NCBIHuRef
CHM1_1X122,904,824 - 122,959,188 (+)NCBICHM1_1
T2T-CHM13v2.0X122,170,108 - 122,224,373 (+)NCBIT2T-CHM13v2.0
Xiap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X41,148,483 - 41,198,541 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX41,148,556 - 41,198,533 (+)EnsemblGRCm39 Ensembl
GRCm38X42,059,613 - 42,109,664 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX42,059,679 - 42,109,656 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X39,421,013 - 39,462,841 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X38,338,355 - 38,350,128 (+)NCBIMGSCv36mm8
CeleraX29,643,660 - 29,685,399 (+)NCBICelera
Cytogenetic MapXA4NCBI
cM MapX23.19NCBI
Xiap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X125,756,107 - 125,803,979 (+)NCBIGRCr8
mRatBN7.2X120,890,537 - 120,938,413 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX120,897,907 - 120,934,700 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX123,009,934 - 123,046,397 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X126,531,344 - 126,567,796 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X124,125,427 - 124,161,835 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X128,409,425 - 128,455,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX128,409,472 - 128,453,000 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X128,500,115 - 128,546,515 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X3,011,520 - 3,047,798 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X3,013,139 - 3,049,418 (-)NCBI
CeleraX120,012,721 - 120,049,014 (+)NCBICelera
Cytogenetic MapXq35NCBI
Xiap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547310,827,435 - 10,840,604 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547310,823,795 - 10,878,256 (-)NCBIChiLan1.0ChiLan1.0
XIAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X123,332,452 - 123,385,525 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X123,336,052 - 123,389,136 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X113,052,164 - 113,105,160 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X123,232,643 - 123,284,912 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX123,232,643 - 123,278,606 (+)Ensemblpanpan1.1panPan2
Xiap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X94,265,438 - 94,309,960 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364796,677,526 - 6,722,116 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364796,677,533 - 6,724,800 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XIAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX101,399,812 - 101,440,013 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X101,399,374 - 101,440,021 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X116,234,274 - 116,253,044 (+)NCBISscrofa10.2Sscrofa10.2susScr3
XIAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606536,593,463 - 36,643,836 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in XIAP
356 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 8 1 3 10
Low 3 5 14 6 6 6 5 6 9 8 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001284458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014111320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014111321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014111323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014111324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022415498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022415499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038448825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038448826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038448827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038448828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038448829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038448830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038448831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_538165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY603038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ225116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000038518   ⟹   ENSCAFP00000034255
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX95,331,827 - 95,351,582 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845045351   ⟹   ENSCAFP00845035569
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 EnsemblX97,072,142 - 97,127,986 (+)Ensembl
RefSeq Acc Id: NM_001284458   ⟹   NP_001271387
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X95,331,827 - 95,351,582 (+)NCBI
Dog10K_Boxer_TashaX81,399,414 - 81,419,171 (+)NCBI
ROS_Cfam_1.0X97,103,716 - 97,123,474 (+)NCBI
UMICH_Zoey_3.1X94,548,275 - 94,568,035 (+)NCBI
UNSW_CanFamBas_1.0X96,304,355 - 96,324,070 (+)NCBI
UU_Cfam_GSD_1.0X96,093,813 - 96,113,573 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038448825   ⟹   XP_038304753
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X97,072,115 - 97,127,995 (+)NCBI
RefSeq Acc Id: XM_038448826   ⟹   XP_038304754
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X97,072,340 - 97,127,995 (+)NCBI
RefSeq Acc Id: XM_038448827   ⟹   XP_038304755
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X97,072,115 - 97,127,995 (+)NCBI
RefSeq Acc Id: XM_038448828   ⟹   XP_038304756
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X97,072,121 - 97,127,995 (+)NCBI
RefSeq Acc Id: XM_038448829   ⟹   XP_038304757
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X97,072,133 - 97,127,995 (+)NCBI
RefSeq Acc Id: XM_038448830   ⟹   XP_038304758
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X97,094,958 - 97,127,995 (+)NCBI
RefSeq Acc Id: XM_038448831   ⟹   XP_038304759
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X97,072,115 - 97,127,995 (+)NCBI
RefSeq Acc Id: NP_001271387   ⟸   NM_001284458
- UniProtKB: Q38IV1 (UniProtKB/TrEMBL),   A0A8C0JL36 (UniProtKB/TrEMBL),   F1PT68 (UniProtKB/TrEMBL),   A0A8C0T2T5 (UniProtKB/TrEMBL),   A0A8C0MJT5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000034255   ⟸   ENSCAFT00000038518
RefSeq Acc Id: XP_038304755   ⟸   XM_038448827
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JL36 (UniProtKB/TrEMBL),   F1PT68 (UniProtKB/TrEMBL),   A0A8C0T2T5 (UniProtKB/TrEMBL),   Q38IV1 (UniProtKB/TrEMBL),   A0A8C0MJT5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038304753   ⟸   XM_038448825
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JL36 (UniProtKB/TrEMBL),   F1PT68 (UniProtKB/TrEMBL),   A0A8C0T2T5 (UniProtKB/TrEMBL),   Q38IV1 (UniProtKB/TrEMBL),   A0A8C0MJT5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038304759   ⟸   XM_038448831
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JL36 (UniProtKB/TrEMBL),   F1PT68 (UniProtKB/TrEMBL),   A0A8C0T2T5 (UniProtKB/TrEMBL),   Q38IV1 (UniProtKB/TrEMBL),   A0A8C0MJT5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038304756   ⟸   XM_038448828
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JL36 (UniProtKB/TrEMBL),   F1PT68 (UniProtKB/TrEMBL),   A0A8C0T2T5 (UniProtKB/TrEMBL),   Q38IV1 (UniProtKB/TrEMBL),   A0A8C0MJT5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038304757   ⟸   XM_038448829
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JL36 (UniProtKB/TrEMBL),   F1PT68 (UniProtKB/TrEMBL),   A0A8C0T2T5 (UniProtKB/TrEMBL),   Q38IV1 (UniProtKB/TrEMBL),   A0A8C0MJT5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038304754   ⟸   XM_038448826
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JL36 (UniProtKB/TrEMBL),   F1PT68 (UniProtKB/TrEMBL),   A0A8C0T2T5 (UniProtKB/TrEMBL),   Q38IV1 (UniProtKB/TrEMBL),   A0A8C0MJT5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038304758   ⟸   XM_038448830
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JL36 (UniProtKB/TrEMBL),   F1PT68 (UniProtKB/TrEMBL),   A0A8C0T2T5 (UniProtKB/TrEMBL),   Q38IV1 (UniProtKB/TrEMBL),   A0A8C0MJT5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845035569   ⟸   ENSCAFT00845045351
Protein Domains
BIRC2/3-like UBA   RING-type

Promoters
RGD ID:13689425
Promoter ID:EPDNEW_C7492
Type:initiation region
Name:XIAP_1
Description:E3 ubiquitin-protein ligase XIAP
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X95,300,697 - 95,300,757EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018577 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030007108 UniProtKB/TrEMBL
  ENSCAFG00040017954 UniProtKB/TrEMBL
  ENSCAFG00845025680 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000038518.4 UniProtKB/TrEMBL
  ENSCAFT00030013039.1 UniProtKB/TrEMBL
  ENSCAFT00040033141.1 UniProtKB/TrEMBL
  ENSCAFT00845045351 ENTREZGENE
  ENSCAFT00845045351.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
InterPro BIR_rpt UniProtKB/TrEMBL
  BIRC2-3-like_UBA UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  XIAP/BIRC8_UBA UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report cfa:442989 UniProtKB/TrEMBL
NCBI Gene XIAP ENTREZGENE
PANTHER DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2 UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE XIAP UniProtKB/TrEMBL
  INHIBITOR OF APOPTOSIS UniProtKB/TrEMBL
Pfam BIR UniProtKB/TrEMBL
  BIRC2-3-like_UBA UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/TrEMBL
PROSITE BIR_REPEAT_1 UniProtKB/TrEMBL
  BIR_REPEAT_2 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART BIR UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
Superfamily-SCOP Inhibitor of apoptosis (IAP) repeat UniProtKB/TrEMBL
  RING/U-box UniProtKB/TrEMBL
UniProt A0A8C0JL36 ENTREZGENE
  A0A8C0MJT5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T2T5 ENTREZGENE, UniProtKB/TrEMBL
  F1PT68 ENTREZGENE
  Q38IV1 ENTREZGENE, UniProtKB/TrEMBL
  Q6J3R0_CANLF UniProtKB/TrEMBL
UniProt Secondary F1PT68 UniProtKB/TrEMBL