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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620692
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Xiap
Name: X-linked inhibitor of apoptosis
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xiapmultiple interactionsISOXIAP (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [[Bortezomib co-treated with Butyrates] results in decreased expression of XIAP protein]; Acetylcysteine inhibits the reaction [[Bortezomib co-treated with vorinostat] results in decreased expression of XIAP protein]; Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of XIAP protein]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in decreased expression of XIAP protein]; Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of XIAP protein]PMID:15173093 PMID:19679660 PMID:21310227 PMID:22578287
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