RGD Reference Report - Survivin and caspase-3 expression in breast cancer: correlation with prognostic parameters, proliferation, angiogenesis, and outcome. - Rat Genome Database

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Survivin and caspase-3 expression in breast cancer: correlation with prognostic parameters, proliferation, angiogenesis, and outcome.

Authors: Nassar, A  Lawson, D  Cotsonis, G  Cohen, C 
Citation: Nassar A, etal., Appl Immunohistochem Mol Morphol. 2008 Mar;16(2):113-20.
RGD ID: 2293092
Pubmed: PMID:18227733   (View Abstract at PubMed)
DOI: DOI:10.1097/PAI.0b013e318032ea73   (Journal Full-text)

BACKGROUND: Survivin is an inhibitor of apoptosis protein that is overexpressed in most human cancers, including breast, but is not expressed in normal tissue. Survivin is associated with more aggressive behavior and decreased survival in a variety of tumor types. It regulates the G2/M phase of the cell cycle by associating with mitotic spindle microtubules, and it directly inhibits caspase-3 and caspase-7 activity. We used a breast cancer tissue microarray to assess survivin and caspase-3 expression in breast cancer and to correlate both markers with proliferation (MIB-1), angiogenesis (CD31), and prognosis. DESIGN: A breast cancer tissue microarray with a total of 190 1-mm tissue samples (2 from each specimen) were immunostained for survivin, caspase-3, MIB-1, and CD31. The microarray contains 91 cases of breast carcinoma diagnosed at Emory University Hospital between 1992 and 2000, and 4 normal breast tissue controls. Follow-up information was obtained from hospital records and the Winship Cancer Center database. RESULTS: Eighty-four percent of breast carcinoma showed nuclear survivin expression. Normal breast tissue was immunonegative. Fifty-seven percent and 43% of breast cancer showed reduced and absent caspase-3 expression, respectively. Survivin (nuclear) and caspase (nuclear/cytoplasmic) expression showed significant correlation with histologic grade (P=0.008 and 0.041) and MIB-1 expression (P=0.033 and 0.012). Survivin nuclear expression also correlated significantly with tumor stage (P=0.012) and tended to correlate with estrogen receptor (P=0.050). There was no significant correlation between survivin and caspase expression. Furthermore, there was no correlation of both markers with other clinicopathologic parameters (age, tumor size, histologic type, progesterone receptor, Her-2 neu status, lymph node status), angiogenesis (CD31), or outcome (overall and disease-free survival). CONCLUSIONS: Survivin and caspase-3 expression correlate with poor prognostic parameters (higher histologic grade and high proliferation), but not with outcome, in breast carcinoma patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
breast cancer severityIEP 2293092protein:decreased expression:breastRGD 
breast cancer severityISOCASP3 (Homo sapiens)2293092; 2293092protein:decreased expression:breastRGD 
Breast Neoplasms disease_progressionIEP 2293092protein:increased expression:breastRGD 
Breast Neoplasms disease_progressionISOBIRC5 (Homo sapiens)2293092; 2293092protein:increased expression:breastRGD 

Objects Annotated

Genes (Rattus norvegicus)
Birc5  (baculoviral IAP repeat-containing 5)
Casp3  (caspase 3)

Genes (Mus musculus)
Birc5  (baculoviral IAP repeat-containing 5)
Casp3  (caspase 3)

Genes (Homo sapiens)
BIRC5  (baculoviral IAP repeat containing 5)
CASP3  (caspase 3)


Additional Information