CASP3 (caspase 3) - Rat Genome Database

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Gene: CASP3 (caspase 3) Chlorocebus sabaeus
Analyze
Symbol: CASP3
Name: caspase 3
RGD ID: 18681775
Description: ENCODES a protein that exhibits cysteine-type peptidase activity (ortholog); death receptor binding (ortholog); phospholipase A2 activator activity (ortholog); INVOLVED IN anterior neural tube closure (ortholog); apoptotic process (ortholog); axonal fasciculation (ortholog); PARTICIPATES IN apoptotic cell death pathway; extrinsic apoptotic pathway; FasL mediated signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Liver Failure (ortholog); Acute Lung Injury (ortholog); FOUND IN cytoplasm (ortholog); death-inducing signaling complex (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: caspase-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17130,589,592 - 130,610,845 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7130,591,166 - 130,610,899 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037110,841,187 - 110,862,527 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute myocardial infarction  (ISO)
acute necrotizing pancreatitis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
atherosclerosis  (ISO)
bacterial infectious disease  (ISO)
Brain Contusion  (ISO)
brain glioma  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
bronchopulmonary dysplasia  (ISO)
Burns  (ISO)
calcinosis  (ISO)
cataract  (ISO)
Cerebral Hemorrhage  (ISO)
cervical cancer  (ISO)
chemical colitis  (ISO)
Chronic Hepatitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon cancer  (ISO)
Colonic Neoplasms  (ISO)
congestive heart failure  (ISO)
Contrast-Induced Nephropathy  (ISO)
Copper-Overload Cirrhosis  (ISO)
cryptorchidism  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Edema  (ISO)
endometritis  (ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
Fetal Growth Retardation  (ISO)
gastric ulcer  (ISO)
heart disease  (ISO)
heart valve disease  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
Hypercholesterolemia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypoxia  (ISO)
impotence  (ISO)
Insulin Resistance  (ISO)
intermittent claudication  (ISO)
intestinal disease  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
middle cerebral artery infarction  (ISO)
Mycoplasma Infections  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatitis  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
pre-malignant neoplasm  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
retinal detachment  (ISO)
retinal disease  (ISO)
salivary gland disease  (ISO)
sciatic neuropathy  (ISO)
scrapie  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
spermatic cord torsion  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
stomach cancer  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
Testis Reperfusion Injury  (ISO)
toxic encephalopathy  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (ISO)
traumatic brain injury  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
Ventricular Remodeling  (ISO)
Viral Myocarditis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior neural tube closure  (IEA,ISO)
apoptotic process  (IEA,ISO)
axonal fasciculation  (ISO)
B cell homeostasis  (IEA,ISO)
cell fate commitment  (IEA,ISO)
cellular response to staurosporine  (IEA)
DNA damage response  (IEA,ISO)
epithelial cell apoptotic process  (IEA,ISO)
erythrocyte differentiation  (IEA)
execution phase of apoptosis  (IEA,ISO)
fibroblast apoptotic process  (IEA,ISO)
glial cell apoptotic process  (IEA,ISO)
heart development  (IEA,ISO)
hippocampus development  (ISO)
intracellular signal transduction  (ISO)
intrinsic apoptotic signaling pathway  (IEA)
intrinsic apoptotic signaling pathway in response to osmotic stress  (IEA)
keratinocyte differentiation  (IEA,ISO)
learning or memory  (ISO)
leukocyte apoptotic process  (ISO)
luteolysis  (ISO)
negative regulation of activated T cell proliferation  (IEA,ISO)
negative regulation of B cell proliferation  (IEA,ISO)
negative regulation of cell cycle  (IEA,ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
negative regulation of cytokine production  (IEA)
neuron apoptotic process  (IEA,ISO)
neuron differentiation  (IEA,ISO)
neurotrophin TRK receptor signaling pathway  (IEA,ISO)
positive regulation of amyloid-beta formation  (IEA)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of neuron apoptotic process  (IEA,ISO)
positive regulation of pyroptotic inflammatory response  (IEA)
protein catabolic process  (IEA,ISO)
protein maturation  (IEA)
protein processing  (IEA,ISO)
proteolysis  (IEA)
pyroptotic inflammatory response  (IEA)
regulation of protein stability  (IEA)
regulation of synaptic vesicle cycle  (IEA)
response to amino acid  (ISO)
response to anesthetic  (ISO)
response to auditory stimulus  (ISO)
response to cobalt ion  (ISO)
response to estradiol  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to lipopolysaccharide  (ISO)
response to metal ion  (ISO)
response to nicotine  (ISO)
response to UV  (IEA,ISO)
response to wounding  (IEA,ISO)
response to X-ray  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of sound  (IEA,ISO)
striated muscle cell differentiation  (ISO)
T cell homeostasis  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CASP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17130,589,592 - 130,610,845 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7130,591,166 - 130,610,899 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037110,841,187 - 110,862,527 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CASP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384184,627,696 - 184,649,447 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4184,627,696 - 184,650,062 (-)EnsemblGRCh38hg38GRCh38
GRCh374185,548,850 - 185,570,601 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364185,785,844 - 185,807,623 (-)NCBINCBI36Build 36hg18NCBI36
Build 344185,923,999 - 185,945,750NCBI
Celera4182,877,510 - 182,899,293 (-)NCBICelera
Cytogenetic Map4q35.1NCBI
HuRef4181,303,305 - 181,324,956 (-)NCBIHuRef
CHM1_14185,525,377 - 185,547,156 (-)NCBICHM1_1
T2T-CHM13v2.04187,971,378 - 187,993,131 (-)NCBIT2T-CHM13v2.0
Casp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39847,070,326 - 47,092,733 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl847,070,326 - 47,092,724 (+)EnsemblGRCm39 Ensembl
GRCm38846,617,291 - 46,639,698 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl846,617,291 - 46,639,689 (+)EnsemblGRCm38mm10GRCm38
MGSCv37847,702,803 - 47,724,071 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36848,116,266 - 48,137,534 (+)NCBIMGSCv36mm8
Celera849,300,031 - 49,321,270 (+)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map826.39NCBI
Casp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81652,395,539 - 52,413,794 (-)NCBIGRCr8
mRatBN7.21645,662,910 - 45,681,171 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1645,662,910 - 45,684,648 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1651,061,544 - 51,079,742 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01654,429,112 - 54,447,305 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01649,700,916 - 49,719,114 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01648,845,011 - 48,863,249 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1648,845,012 - 48,863,204 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01648,560,090 - 48,578,325 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41648,944,226 - 48,962,420 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11648,944,301 - 48,962,495 (-)NCBI
Celera1643,665,975 - 43,684,168 (-)NCBICelera
Cytogenetic Map16q11NCBI
Casp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540324,315,712 - 24,326,271 (+)NCBIChiLan1.0ChiLan1.0
CASP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23182,351,669 - 182,373,528 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14182,713,461 - 182,735,319 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04176,793,190 - 176,815,023 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14189,018,422 - 189,040,217 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4189,018,422 - 189,040,185 (-)Ensemblpanpan1.1panPan2
CASP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11645,920,074 - 45,940,507 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1645,920,071 - 45,940,505 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1646,413,238 - 46,434,538 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01648,136,012 - 48,157,278 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1648,135,662 - 48,157,268 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11646,101,180 - 46,122,422 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01646,715,535 - 46,736,806 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01646,848,704 - 46,870,015 (+)NCBIUU_Cfam_GSD_1.0
Casp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494333,516,817 - 33,538,924 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365544,571,072 - 4,593,765 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1545,742,751 - 45,764,213 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11545,744,320 - 45,753,252 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21552,291,074 - 52,299,625 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000001027   ⟹   ENSCSAP00000015040
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl7130,591,166 - 130,610,899 (-)Ensembl
RefSeq Acc Id: XM_008000391   ⟹   XP_007998582
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.17130,589,592 - 130,610,845 (-)NCBI
Vero_WHO_p1.0NW_023666037110,841,187 - 110,862,527 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008000392   ⟹   XP_007998583
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.17130,589,592 - 130,610,094 (-)NCBI
Vero_WHO_p1.0NW_023666037110,841,187 - 110,862,496 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037994154   ⟹   XP_037850082
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037110,841,187 - 110,862,491 (-)NCBI
RefSeq Acc Id: XM_037994162   ⟹   XP_037850090
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037110,841,187 - 110,862,491 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007998582 (Get FASTA)   NCBI Sequence Viewer  
  XP_007998583 (Get FASTA)   NCBI Sequence Viewer  
  XP_037850082 (Get FASTA)   NCBI Sequence Viewer  
  XP_037850090 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000015040
  ENSCSAP00000015040.1
RefSeq Acc Id: XP_007998582   ⟸   XM_008000391
- UniProtKB: A0A0D9S2F1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007998583   ⟸   XM_008000392
- UniProtKB: A0A0D9S2F1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000015040   ⟸   ENSCSAT00000001027
RefSeq Acc Id: XP_037850090   ⟸   XM_037994162
- UniProtKB: A0A0D9S2F1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037850082   ⟸   XM_037994154
- UniProtKB: A0A0D9S2F1 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000003002 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000001027.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1460 UniProtKB/TrEMBL
InterPro Caspase-like_dom_sf UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/TrEMBL
  Caspase_his_AS UniProtKB/TrEMBL
  Pept_C14_caspase UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/TrEMBL
  Pept_C14_p20 UniProtKB/TrEMBL
  Pept_C14A UniProtKB/TrEMBL
KEGG Report csab:103236614 UniProtKB/TrEMBL
NCBI Gene CASP3 ENTREZGENE
PANTHER CASPASE-3 UniProtKB/TrEMBL
  PTHR10454 UniProtKB/TrEMBL
Pfam Peptidase_C14 UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/TrEMBL
PROSITE CASPASE_CYS UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/TrEMBL
SMART CASc UniProtKB/TrEMBL
Superfamily-SCOP SSF52129 UniProtKB/TrEMBL
UniProt A0A0D9S2F1 ENTREZGENE, UniProtKB/TrEMBL