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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:132267
Term: triptonide
Definition: A diterpene triepoxide that is triptobenzene K in which the acylhydroquinone moiety has undergone oxidation to the corresponding triepoxyketone derivative. It has been isolated from the roots of Tripterygium wilfordii.
Chemical ID: MESH:C084079
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases cleavageISOCasp3 (Mus musculus)6480464CTDtriptonide results in increased cleavage of CASP3 proteinPMID:33045310
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDtriptonide results in increased cleavage of CASP3 proteinPMID:28666825
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDOBOX4-PS35 affects the reaction [triptonide results in increased cleavage of CASP3 protein]PMID:33045310
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