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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:50729
Term: mitoxantrone
Definition: A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.
Chemical ID: MESH:D008942
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityISOCasp3 (Mus musculus)6480464CTDMitoxantrone results in increased activity of CASP3 proteinPMID:16215684 PMID:32894303
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDMitoxantrone results in increased activity of CASP3 proteinPMID:12948851 PMID:22700542 PMID:8840993
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDacetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]PMID:16215684
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDBCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP3 protein]PMID:22700542 PMID:8840993
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