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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:27789
Term: 1,2-dichloroethane
Definition: A member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2.
Chemical ID: MESH:C024565
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3decreases expressionISOCasp3 (Mus musculus)6480464CTDethylene dichloride results in decreased expression of CASP3 mRNAPMID:28189721 PMID:28960355
Casp3increases cleavageISOCasp3 (Mus musculus)6480464CTDethylene dichloride results in increased cleavage of CASP3 proteinPMID:31520740
Casp3increases expressionISOCasp3 (Mus musculus)6480464CTDethylene dichloride results in increased expression of CASP3 mRNA; ethylene dichloride results in increased expression of CASP3 protein; ethylene dichloride results in increased expression of CASP3 protein modified formPMID:28973639 PMID:34560092
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDethylene dichloride results in increased expression of CASP3 mRNA; ethylene dichloride results in increased expression of CASP3 protein; ethylene dichloride results in increased expression of CASP3 protein modified formPMID:34560092
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[Antagomirs results in decreased expression of MIR182 mRNA] inhibits the reaction [ethylene dichloride results in increased expression of CASP3 mRNA]; [Antagomirs results in decreased expression of MIR182 mRNA] inhibits the reaction [ethylene dichloride results in increased expression of CASP3 protein modified form]; [Antagomirs results in decreased expression of MIR182 mRNA] inhibits the reaction [ethylene dichloride results in increased expression of CASP3 protein]PMID:34560092
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