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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:4696
Term: donepezil hydrochloride
Definition: A racemate comprising equimolar amounts of (R)- and (S)- donepezil hydrochloride. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
Chemical ID: MESH:C076946
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDDonepezil inhibits the reaction [Hydrogen Peroxide results in decreased expression of CASP3 protein]PMID:19345205
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDDonepezil results in increased activity of CASP3 proteinPMID:20522977
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDDonepezil inhibits the reaction [Scopolamine results in increased activity of CASP3 protein]PMID:34371027
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