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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:8633
Term: puerarin
Definition: A hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 7 and 4' and a beta-D-glucopyranosyl residue at position 8 via a C-glycosidic linkage.
Chemical ID: MESH:C033607
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDpuerarin inhibits the reaction [cadmium acetate results in increased activity of CASP3 protein]; puerarin inhibits the reaction [lead nitrate results in increased activity of CASP3 protein]; puerarin results in decreased expression of and results in decreased activity of CASP3 proteinPMID:16041641 PMID:24505050 PMID:27717697
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDpuerarin results in increased activity of CASP3 proteinPMID:16055262
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDpuerarin results in increased expression of CASP3 proteinPMID:20416161
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDpuerarin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]PMID:27318789
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDarsenic trioxide promotes the reaction [puerarin results in increased expression of CASP3 protein]PMID:20416161
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