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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:17579
Term: beta-carotene
Definition: A cyclic carotene obtained by dimerisation of all-trans-retinol. A strongly-coloured red-orange pigment abundant in plants and fruit and the most active and important provitamin A carotenoid.
Chemical ID: MESH:D019207
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDbeta Carotene metabolite results in increased activity of CASP3 protein; beta Carotene results in increased activity of CASP3 proteinPMID:17618090 PMID:26733226
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDalpha-Tocopherol promotes the reaction [beta Carotene metabolite results in decreased activity of CASP3 protein]PMID:17618090
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