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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:15866
Term: 2-deoxy-D-glucose
Definition: A deoxyglucose that is D-glucose in which the hydroxy group at position 2 has been replaced by a hydrogen. It is an antimetabolite of glucose with antiviral activity, which acts by inhibiting the glycosylation of glycoproteins and glycolipids. Used as an antiherpes agent.
Chemical ID: MESH:D003847
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityEXP 6480464CTDDeoxyglucose results in increased activity of CASP3 protein

PMID:10506188 PMID:15755911
Casp3multiple interactionsEXP 6480464CTDCorticosterone inhibits the reaction [Deoxyglucose results in increased activity of CASP3 protein] GPX4 protein inhibits the reaction [Deoxyglucose results in increased activity of CASP3 protein]

PMID:10506188 PMID:15755911
Casp3increases cleavageISORGD:7310026480464CTDDeoxyglucose results in increased cleavage of CASP3 protein

PMID:20593179
Casp3multiple interactionsISORGD:102896480464CTDDeoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]]

PMID:29095437
Casp3multiple interactionsISORGD:7310026480464CTDATG7 protein inhibits the reaction [Deoxyglucose results in increased cleavage of CASP3 protein] Deoxyglucose promotes the reaction [Arsenic Trioxide results in increased cleavage of and results in increased activity of CASP3 protein] Deoxyglucose results in increased cleavage of and results in increased activity of CASP3 protein

PMID:20593179 PMID:23041229
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