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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:6052
Term: isorhamnetin
Definition: A monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group.
Chemical ID: MESH:C047368
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTD3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]PMID:19222219
Casp3decreases expressionISOCASP3 (Homo sapiens)6480464CTD3-methylquercetin results in decreased expression of CASP3 proteinPMID:22992727
Casp3increases activityISOCasp3 (Mus musculus)6480464CTD3-methylquercetin results in increased activity of CASP3 proteinPMID:12826665
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