GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp3 | increases activity | EXP | | 6480464 | CTD | Arsenic results in increased activity of CASP3 protein | PMID:20114059 PMID:24295472 | Casp3 | increases expression | EXP | | 6480464 | CTD | Arsenic results in increased expression of CASP3 mRNA; Arsenic results in increased expression of CASP3 protein | PMID:32246071 PMID:36813806 PMID:36850985 | Casp3 | multiple interactions | EXP | | 6480464 | CTD | 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP3 protein]; [Lead co-treated with Manganese co-treated with Cadmium co-treated with Arsenic] results in increased expression of CASP3 mRNA; [sodium arsenate results in increased abundance of Arsenic] which results in increased activity of CASP3 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP3 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of and results in increased cleavage of CASP3 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CASP3 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CASP3 protein; [Sodium Fluoride co-treated with [sodium arsenate results in increased abundance of Arsenic]] results in increased activity of CASP3 protein; [Streptozocin co-treated with Arsenic] results in increased expression of CASP3 mRNA; [Streptozocin co-treated with Lead co-treated with Manganese co-treated with Cadmium co-treated with Arsenic] results in increased expression of CASP3 mRNA; Arsenic results in increased cleavage of and results in increased activity of CASP3 protein; Ascorbic Acid inhibits the reaction [Arsenic results in increased activity of CASP3 protein]; BDNF protein inhibits the reaction [Arsenic results in increased cleavage of and results in increased activity of CASP3 protein]; diallyl trisulfide inhibits the reaction [Arsenic results in increased activity of CASP3 protein]; fisetin inhibits the reaction [Arsenic results in increased expression of CASP3 mRNA]; IL1RN protein inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP3 protein]; Lithium Chloride inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of and results in increased cleavage of CASP3 protein]; nobiletin inhibits the reaction [Arsenic results in increased expression of CASP3 protein]; NOG protein inhibits the reaction [Arsenic results in increased cleavage of CASP3 protein]; Sodium Fluoride inhibits the reaction [[sodium arsenate results in increased abundance of Arsenic] which results in increased activity of CASP3 protein]; staurosporine aglycone inhibits the reaction [NOG protein inhibits the reaction [Arsenic results in increased cleavage of CASP3 protein]]; sulforaphane inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CASP3 protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CASP3 mRNA] | PMID:24295472 PMID:28903487 PMID:30835071 PMID:32246071 PMID:35598369 PMID:35993674 PMID:36813806 PMID:36822304 PMID:36850985 PMID:36947368 | Casp3 | increases activity | ISO | Casp3 (Mus musculus) | 6480464 | CTD | Arsenic results in increased activity of CASP3 protein | PMID:10828279 PMID:36117518 | Casp3 | increases cleavage | ISO | Casp3 (Mus musculus) | 6480464 | CTD | Arsenic results in increased cleavage of CASP3 protein | PMID:27289040 | Casp3 | increases expression | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | Arsenic results in increased expression of CASP3 mRNA | PMID:27838757 | Casp3 | multiple interactions | ISO | Casp3 (Mus musculus) | 6480464 | CTD | [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CASP3 protein; [methylmercuric chloride co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CASP3 protein; [sodium arsenite results in increased abundance of Arsenic] promotes the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased expression of CASP3 mRNA]; [sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP3 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CASP3 mRNA; [Sodium Fluoride results in increased abundance of Fluorides] promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CASP3 mRNA]; Glutathione inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP3 protein] | PMID:32179164 PMID:35714946 PMID:36689145 | Casp3 | multiple interactions | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | [[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein; [Palmitic Acid co-treated with Arsenic] affects the expression of CASP3 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP3 protein; AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]]; ATF3 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP3 protein]; MCL1 protein affects the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]; MCL1 protein inhibits the reaction [Sirolimus inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]]; MCL1 protein inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]]; MCL1 protein promotes the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]; NFE2L1 protein alternative form inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]; USP7 protein affects the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]; Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein] | PMID:32188015 PMID:32802178 PMID:33736254 PMID:33921748 | | ||||||||||||||||||||||
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