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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:66470
Term: (+)-sesamin
Definition: A lignan that consists of tetrahydro-1H,3H-furo[3,4-c]furan substituted by 1,3-benzodioxole groups at positions 1 and 4 (the 1S,3aR,4S,6aR stereoisomer). Isolated from Cinnamomum camphora, it exhibits cytotoxic activity.
Chemical ID: MESH:C054125
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDsesamin inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]

PMID:22524206
Casp3multiple interactionsISORGD:102896480464CTDsesamin inhibits the reaction [nickel sulfate results in increased cleavage of CASP3 protein]

PMID:23317420
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.