Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:78510
Term: dorsomorphin
Definition: A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.
Chemical ID: MESH:C516138
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDdorsomorphin inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased cleavage of CASP3 protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]PMID:31433112 PMID:33922211
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDdorsomorphin results in increased cleavage of CASP3 proteinPMID:23274516 PMID:31900833
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD[dorsomorphin inhibits the reaction [ADIPOQ protein results in increased expression of BCL2L1 protein]] which results in increased activity of CASP3 protein; dorsomorphin inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]]; dorsomorphin inhibits the reaction [pseudolaric acid B results in increased cleavage of CASP3 protein]PMID:20709802 PMID:37244295
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDdorsomorphin inhibits the reaction [pachymic acid results in increased activity of CASP3 protein]; dorsomorphin inhibits the reaction [Penfluridol results in increased cleavage of CASP3 protein]; TP53 mutant form inhibits the reaction [dorsomorphin results in increased cleavage of CASP3 protein]PMID:23274516 PMID:35524978 PMID:35530161
Go Back to source page   Continue to Ontology report