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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:310312
Term: isoliquiritigenin
Definition: A member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'.
Chemical ID: MESH:C040920
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityISORGD:7310026480464CTDisoliquiritigenin results in increased activity of CASP3 protein

PMID:15729620 PMID:16158945
Casp3increases cleavageISORGD:7310026480464CTDisoliquiritigenin results in increased cleavage of CASP3 protein

PMID:23747687 PMID:25094029
Casp3multiple interactionsISORGD:7310026480464CTD20-hydroxyeicosa-5Z 14Z-dienoic acid inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein] AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein] benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein] CAY 10580 inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein] Dinoprostone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein] isoliquiritigenin results in increased cleavage of and results in increased activity of CASP3 protein

PMID:23747687 PMID:25094029
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