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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:6121
Term: ketamine
Definition: A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Chemical ID: MESH:D007649
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases cleavageEXP 6480464CTDKetamine results in increased cleavage of CASP3 proteinPMID:33536391
Casp3increases expressionEXP 6480464CTDKetamine results in increased expression of CASP3 mRNA; Ketamine results in increased expression of CASP3 protein; Ketamine results in increased expression of CASP3 protein modified formPMID:25937004 PMID:33536391 PMID:36305173
Casp3multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Ketamine results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 protein]; TRPV4 protein affects the reaction [Ketamine results in increased cleavage of CASP3 protein]; TRPV4 protein affects the reaction [Ketamine results in increased expression of CASP3 mRNA]PMID:33536391 PMID:36305173
Casp3increases activityISOCasp3 (Mus musculus)6480464CTDKetamine results in increased activity of CASP3 proteinPMID:17920787
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDKetamine results in increased activity of CASP3 proteinPMID:19001360
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDKetamine results in increased cleavage of CASP3 proteinPMID:36907275
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDLEP protein promotes the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased cleavage of CASP3 protein]]; lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased cleavage of CASP3 protein]PMID:36907275
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