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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:48765
Term: dimethylarsinic acid
Definition: The organoarsenic compound that is arsenic acid substituted on the central arsenic atom with two methyl groups.
Chemical ID: MESH:D002101
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityEXP 6480464CTDCacodylic Acid results in increased activity of CASP3 proteinPMID:15276415
Casp3increases expressionEXP 6480464CTDCacodylic Acid results in increased expression of CASP3 mRNAPMID:16122865
Casp3increases response to substanceEXP 6480464CTDCASP3 protein results in increased susceptibility to Cacodylic AcidPMID:15276415
Casp3multiple interactionsEXP 6480464CTDbenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [CASP3 protein results in increased susceptibility to Cacodylic Acid]; Buthionine Sulfoximine inhibits the reaction [Cacodylic Acid results in increased activity of CASP3 protein]PMID:15276415
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDCacodylic Acid analog results in increased activity of CASP3 protein; Cacodylic Acid results in increased activity of CASP3 proteinPMID:19465042 PMID:23994116
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of CASP3 mRNAPMID:23192986
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