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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:3423
Term: carmustine
Definition: A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Chemical ID: MESH:D002330
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityEXP 6480464CTDCarmustine results in increased activity of CASP3 proteinPMID:20046642
Casp3multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Carmustine results in increased activity of and results in increased cleavage of CASP3 protein]; [LCN2 protein co-treated with Carmustine] results in increased cleavage of and results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Carmustine results in increased activity of and results in increased cleavage of CASP3 protein]; Carmustine results in increased activity of and results in increased cleavage of CASP3 protein; pyrazolanthrone inhibits the reaction [Carmustine results in increased activity of and results in increased cleavage of CASP3 protein]; Zinc Sulfate inhibits the reaction [Carmustine results in increased activity of CASP3 protein]PMID:19860839 PMID:20046642 PMID:21600974
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDCarmustine results in increased cleavage of CASP3 proteinPMID:24193513
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDCarmustine results in increased expression of CASP3 proteinPMID:20920327
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[Carmustine co-treated with 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid] results in increased activity of CASP3 protein; Disulfiram promotes the reaction [Carmustine results in increased cleavage of CASP3 protein]PMID:18590702 PMID:24193513
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