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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:46979
Term: N-acetylsphingosine
Definition: A N-acylsphingosine that has an acetamido group at position 2.
Chemical ID: MESH:C064769
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityISORGD:102896480464CTDN-acetylsphingosine results in increased activity of CASP3 protein

PMID:10919278
Casp3increases activityISORGD:7310026480464CTDN-acetylsphingosine results in increased activity of CASP3 protein

PMID:21259059
Casp3multiple interactionsISORGD:7310026480464CTDBCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein] N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein

PMID:16215670
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