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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:77986
Term: dibenziodolium
Definition: An organic cation that is fluorene in which the methylene group is replaced by a positively charged iodine.
Chemical ID: MESH:C007517
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTD[diphenyleneiodonium co-treated with mitoquinol co-treated with mitoquinone] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; diphenyleneiodonium inhibits the reaction [TGFB1 protein results in increased activity of CASP3 protein]PMID:14732287 PMID:15799720 PMID:25947082
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDdiphenyleneiodonium inhibits the reaction [AGT protein modified form results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [Ethanol results in increased activity of CASP3 protein]PMID:12606818 PMID:20026259
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDdiphenyleneiodonium inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [Docetaxel results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [ganoderic acid analog results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [ganoderic acid T analog results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [ganoderic acid T results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [Patulin results in increased activity of CASP3 protein]PMID:12754411 PMID:15331178 PMID:26282491 PMID:33577942
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