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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:28812
Term: (aminomethyl)phosphonic acid
Definition: A member of the class of phosphonic acids that is phosphonic acid substituted by an aminomethyl group. It is a metabolite of the herbicide glyphosate.
Chemical ID: MESH:C036423
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityISORGD:7310026480464CTD1-aminomethylphosphonic acid results in increased activity of CASP3 protein

PMID:23983455
Casp3multiple interactionsISORGD:7310026480464CTD[1-aminomethylphosphonic acid co-treated with methoxyacetic acid] results in increased cleavage of and results in increased activity of CASP3 protein

PMID:26006246
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