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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:7713
Term: Obacunone
Definition: A limonoid that has formula C26H30O7.
Chemical ID: MESH:C067207
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3decreases expressionISOCASP3 (Homo sapiens)6480464CTDobacunone results in decreased expression of CASP3 proteinPMID:21333732
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDobacunone results in increased activity of CASP3 proteinPMID:21333732
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDobacunone results in increased cleavage of and results in increased activity of CASP3 proteinPMID:25592883
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