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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:18243
Term: dopamine
Definition: Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group.
Chemical ID: MESH:D004298
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityEXP 6480464CTDDopamine results in increased activity of CASP3 proteinPMID:18194434
Casp3multiple interactionsEXP 6480464CTDSH-6 compound promotes the reaction [Dopamine results in increased activity of CASP3 protein]; SH-6 compound promotes the reaction [tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]]; tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]PMID:18194434
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDDopamine results in increased activity of CASP3 proteinPMID:19410601 PMID:22987761
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDDopamine results in increased cleavage of CASP3 proteinPMID:15198987
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[Dopamine co-treated with Zinc deficiency] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Dopamine results in increased activity of and results in increased cleavage of CASP3 protein]; Dopamine results in increased activity of and results in increased cleavage of CASP3 protein; Dopamine results in increased cleavage of and results in increased activity of CASP3 protein; PRKN protein inhibits the reaction [Dopamine results in increased cleavage of CASP3 protein]; resveratrol inhibits the reaction [Dopamine results in increased cleavage of and results in increased activity of CASP3 protein]PMID:15198987 PMID:17136323 PMID:17603292 PMID:23377617
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