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Gene: Casp6 (caspase 6) Rattus norvegicus
Symbol: Casp6
Name: caspase 6
Description: Exhibits endopeptidase activity. Involved in several processes, including acute inflammatory response to non-antigenic stimulus; axonal fasciculation; and positive regulation of programmed cell death. Localizes to several cellular components, including axon; cytosol; and neuronal cell body. Used to study status epilepticus. Biomarker of brain ischemia; endometritis; middle cerebral artery infarction; and prostate carcinoma. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CASP6 (caspase 6); PARTICIPATES IN apoptotic cell death pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: apoptotic protease Mch-2; CASP-6; caspase-6; Mch2; MGC93335
Homo sapiens (human) : CASP6 (caspase 6)  HGNC  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Casp6 (caspase 6)
Pan paniscus (bonobo/pygmy chimpanzee) : CASP6 (caspase 6)
Canis lupus familiaris (dog) : CASP6 (caspase 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Casp6 (caspase 6)
Sus scrofa (pig) : CASP6 (caspase 6)
Chlorocebus sabaeus (African green monkey) : CASP6 (caspase 6)
Heterocephalus glaber (naked mole-rat) : Casp6 (caspase 6)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02235,341,326 - 235,353,715 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2235,341,365 - 235,353,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl2230,186,198 - 230,198,555 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02249,539,649 - 249,552,032 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42227,361,538 - 227,373,844 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12227,348,217 - 227,360,523 (+)NCBI
Celera2210,748,422 - 210,760,763 (+)NCBICelera
Cytogenetic Map2q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Casp6
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70967
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.