CASP6 (caspase 6) - Rat Genome Database

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Gene: CASP6 (caspase 6) Sus scrofa
Analyze
Symbol: CASP6
Name: caspase 6
RGD ID: 14075643
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); INVOLVED IN acute inflammatory response to non-antigenic stimulus (ortholog); axonal fasciculation (ortholog); lens development in camera-type eye (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); brain ischemia (ortholog); Breast Neoplasms (ortholog); FOUND IN axon (ortholog); neuronal cell body (ortholog); INTERACTS WITH cyclosporin A; lipopolysaccharide; vitamin E
Type: protein-coding
RefSeq Status: MODEL
Previously known as: caspase-6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8112,520,629 - 112,537,045 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18112,519,450 - 112,534,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28120,664,346 - 120,678,399 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (ISO)
cytoplasm  (IBA,IEA)
cytosol  (IEA)
neuronal cell body  (ISO)
nucleoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CASP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8112,520,629 - 112,537,045 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18112,519,450 - 112,534,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28120,664,346 - 120,678,399 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CASP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384109,664,388 - 109,709,767 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4109,688,622 - 109,703,583 (-)EnsemblGRCh38hg38GRCh38
GRCh374110,609,784 - 110,624,601 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364110,829,234 - 110,844,078 (-)NCBINCBI36Build 36hg18NCBI36
Build 344110,967,388 - 110,982,233NCBI
Celera4107,903,448 - 107,918,292 (-)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4106,342,777 - 106,357,627 (-)NCBIHuRef
CHM1_14110,586,394 - 110,601,238 (-)NCBICHM1_1
T2T-CHM13v2.04112,966,324 - 113,010,471 (-)NCBIT2T-CHM13v2.0
Casp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393129,695,064 - 129,707,761 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3129,695,074 - 129,707,752 (+)EnsemblGRCm39 Ensembl
GRCm383129,901,415 - 129,914,112 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,901,425 - 129,914,103 (+)EnsemblGRCm38mm10GRCm38
MGSCv373129,604,343 - 129,617,020 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363129,893,486 - 129,905,973 (+)NCBIMGSCv36mm8
Celera3136,415,853 - 136,428,433 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map359.5NCBI
Casp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82221,140,287 - 221,152,727 (+)NCBIGRCr8
mRatBN7.22218,466,063 - 218,478,503 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2218,466,076 - 218,478,502 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2226,144,507 - 226,156,834 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02224,044,202 - 224,056,533 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02218,901,851 - 218,914,178 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02235,341,326 - 235,353,715 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2235,341,365 - 235,353,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl2230,186,198 - 230,198,555 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02249,539,649 - 249,552,032 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42227,361,538 - 227,373,844 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12227,348,217 - 227,360,523 (+)NCBI
Celera2210,748,422 - 210,760,763 (+)NCBICelera
Cytogenetic Map2q43NCBI
Casp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955496577,832 - 584,287 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955496575,839 - 584,287 (+)NCBIChiLan1.0ChiLan1.0
CASP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23107,781,319 - 107,798,789 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14108,075,317 - 108,092,294 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04102,186,215 - 102,201,992 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14112,753,988 - 112,768,836 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4112,753,988 - 112,768,836 (-)Ensemblpanpan1.1panPan2
CASP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13229,897,706 - 29,910,522 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3229,897,823 - 29,911,469 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3212,119,155 - 12,132,295 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03230,117,004 - 30,130,146 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3230,117,008 - 30,130,778 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13230,111,494 - 30,124,567 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03229,855,989 - 29,869,067 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,980,365 - 9,993,491 (+)NCBIUU_Cfam_GSD_1.0
Casp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530111,030,886 - 11,038,493 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936563911,304 - 919,119 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936563912,502 - 920,025 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1757,592,632 - 57,616,094 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl757,593,342 - 57,607,489 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603736,243,873 - 36,268,826 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Casp6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624830171,427 - 184,814 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624830170,392 - 179,883 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CASP6
718 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000010007   ⟹   ENSSSCP00000009745
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8112,483,392 - 112,529,597 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000010008   ⟹   ENSSSCP00000009746
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8112,520,629 - 112,534,314 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000047809   ⟹   ENSSSCP00000052662
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8112,520,861 - 112,534,314 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000073594   ⟹   ENSSSCP00000068855
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8112,520,629 - 112,537,045 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000097858   ⟹   ENSSSCP00000080049
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8112,529,352 - 112,534,314 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000099257   ⟹   ENSSSCP00000077592
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8112,520,629 - 112,529,597 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000105773   ⟹   ENSSSCP00000077536
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8112,520,629 - 112,534,314 (+)Ensembl
RefSeq Acc Id: XM_005656547   ⟹   XP_005656604
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18112,520,164 - 112,534,315 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013989349   ⟹   XP_013844803
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18112,519,450 - 112,534,315 (+)NCBI
Sequence:
RefSeq Acc Id: XP_013844803   ⟸   XM_013989349
- Peptide Label: isoform X2
- UniProtKB: A0A8D0K1M4 (UniProtKB/TrEMBL),   F1S131 (UniProtKB/TrEMBL),   A0A4X1UW10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005656604   ⟸   XM_005656547
- Peptide Label: isoform X1
- UniProtKB: A0A4X1UXQ4 (UniProtKB/TrEMBL),   A0A0B8S0B0 (UniProtKB/TrEMBL),   A0A8W4FDP3 (UniProtKB/TrEMBL),   A0A8D1XN22 (UniProtKB/TrEMBL),   A0A8D0QWP5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000068855   ⟸   ENSSSCT00000073594
Ensembl Acc Id: ENSSSCP00000009745   ⟸   ENSSSCT00000010007
Ensembl Acc Id: ENSSSCP00000009746   ⟸   ENSSSCT00000010008
Ensembl Acc Id: ENSSSCP00000052662   ⟸   ENSSSCT00000047809
Ensembl Acc Id: ENSSSCP00000077536   ⟸   ENSSSCT00000105773
Ensembl Acc Id: ENSSSCP00000080049   ⟸   ENSSSCT00000097858
Ensembl Acc Id: ENSSSCP00000077592   ⟸   ENSSSCT00000099257
Protein Domains
Caspase family p10   Caspase family p20


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009140 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015029118 UniProtKB/TrEMBL
  ENSSSCG00025007262 UniProtKB/TrEMBL
  ENSSSCG00035076233 UniProtKB/TrEMBL
  ENSSSCG00040067651 UniProtKB/TrEMBL
  ENSSSCG00045028068 UniProtKB/TrEMBL
  ENSSSCG00055008418 UniProtKB/TrEMBL
  ENSSSCG00060074875 UniProtKB/TrEMBL
  ENSSSCG00065011769 UniProtKB/TrEMBL
  ENSSSCG00070020201 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010008 ENTREZGENE
  ENSSSCT00000010008.5 UniProtKB/TrEMBL
  ENSSSCT00000047809.3 UniProtKB/TrEMBL
  ENSSSCT00000073594.2 UniProtKB/TrEMBL
  ENSSSCT00000097858.1 UniProtKB/TrEMBL
  ENSSSCT00000099257.1 UniProtKB/TrEMBL
  ENSSSCT00000105773 ENTREZGENE
  ENSSSCT00000105773.1 UniProtKB/TrEMBL
  ENSSSCT00015039012.1 UniProtKB/TrEMBL
  ENSSSCT00015039197.1 UniProtKB/TrEMBL
  ENSSSCT00025009676.1 UniProtKB/TrEMBL
  ENSSSCT00025009685.1 UniProtKB/TrEMBL
  ENSSSCT00025009690.1 UniProtKB/TrEMBL
  ENSSSCT00035103819.1 UniProtKB/TrEMBL
  ENSSSCT00035103844.1 UniProtKB/TrEMBL
  ENSSSCT00035103883.1 UniProtKB/TrEMBL
  ENSSSCT00040092825.1 UniProtKB/TrEMBL
  ENSSSCT00040092943.1 UniProtKB/TrEMBL
  ENSSSCT00045048237.1 UniProtKB/TrEMBL
  ENSSSCT00045048328.1 UniProtKB/TrEMBL
  ENSSSCT00045048436.1 UniProtKB/TrEMBL
  ENSSSCT00055016723.1 UniProtKB/TrEMBL
  ENSSSCT00055016785.1 UniProtKB/TrEMBL
  ENSSSCT00055016880.1 UniProtKB/TrEMBL
  ENSSSCT00060102662.1 UniProtKB/TrEMBL
  ENSSSCT00060102711.1 UniProtKB/TrEMBL
  ENSSSCT00065015653.1 UniProtKB/TrEMBL
  ENSSSCT00065015669.1 UniProtKB/TrEMBL
  ENSSSCT00065015671.1 UniProtKB/TrEMBL
  ENSSSCT00065015702.1 UniProtKB/TrEMBL
  ENSSSCT00070040104.1 UniProtKB/TrEMBL
  ENSSSCT00070040107.1 UniProtKB/TrEMBL
  ENSSSCT00070040113.1 UniProtKB/TrEMBL
  ENSSSCT00070040115.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1460 UniProtKB/TrEMBL
InterPro Caspase-like_dom_sf UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/TrEMBL
  Caspase_his_AS UniProtKB/TrEMBL
  Pept_C14_caspase UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/TrEMBL
  Pept_C14_p20 UniProtKB/TrEMBL
  Pept_C14A UniProtKB/TrEMBL
KEGG Report ssc:100517293 UniProtKB/TrEMBL
NCBI Gene CASP6 ENTREZGENE
PANTHER CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18 UniProtKB/TrEMBL
  CASPASE-12 UniProtKB/TrEMBL
  CASPASE-3 UniProtKB/TrEMBL
  PTHR10454 UniProtKB/TrEMBL
  PTHR10454:SF206 UniProtKB/TrEMBL
Pfam Peptidase_C14 UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/TrEMBL
PROSITE CASPASE_CYS UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/TrEMBL
SMART CASc UniProtKB/TrEMBL
Superfamily-SCOP SSF52129 UniProtKB/TrEMBL
UniProt A0A0B8S0B0 ENTREZGENE
  A0A287B811_PIG UniProtKB/TrEMBL
  A0A4X1UU59_PIG UniProtKB/TrEMBL
  A0A4X1UW10 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UXQ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QXI3_PIG UniProtKB/TrEMBL
  A0A8D0JZD6_PIG UniProtKB/TrEMBL
  A0A8D0K1M4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0N9Y5_PIG UniProtKB/TrEMBL
  A0A8D0QWP5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1XN22 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FDP3 ENTREZGENE
  A0A8W4FL33_PIG UniProtKB/TrEMBL
  F1S131 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8W4FDP3 UniProtKB/TrEMBL
  A0A8W4FEA9 UniProtKB/TrEMBL
VGNC ID VGNC:86202 ENTREZGENE