CASP6 (caspase 6) - Rat Genome Database

Name: CASP6
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: CASP6 (caspase 6) Sus scrofa

Analyze

Symbol:

CASP6

Name:

caspase 6

RGD ID:

14075643

Description:

ENCODES a protein that exhibits endopeptidase activity (ortholog); INVOLVED IN acute inflammatory response to non-antigenic stimulus (ortholog); axonal fasciculation (ortholog); lens development in camera-type eye (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); brain ischemia (ortholog); Breast Neoplasms (ortholog); FOUND IN axon (ortholog); neuronal cell body (ortholog); INTERACTS WITH cyclosporin A; lipopolysaccharide; vitamin E

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

caspase-6

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CASP6 (caspase 6)	HGNC	EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Casp6 (caspase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Casp6 (caspase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Casp6 (caspase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CASP6 (caspase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CASP6 (caspase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Casp6 (caspase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CASP6 (caspase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Casp6 (caspase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	112,520,629 - 112,537,045 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	112,519,450 - 112,534,315 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	120,664,346 - 120,678,399 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

brain ischemia (ISO)

Breast Neoplasms (ISO)

chronic myeloid leukemia (ISO)

ductal carcinoma in situ (ISO)

endometritis (ISO)

Experimental Diabetes Mellitus (ISO)

genetic disease (ISO)

lung non-small cell carcinoma (ISO)

middle cerebral artery infarction (ISO)

Osteoarthritis, Experimental (ISO)

ovarian carcinoma (ISO)

prostate carcinoma (ISO)

prostatic hypertrophy (ISO)

Reperfusion Injury (ISO)

Sepsis (ISO)

status epilepticus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

cyclosporin A (EXP)

lipopolysaccharide (EXP)

vitamin E (EXP)

zinc sulfate (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of innate immune response (IEA)

acute inflammatory response to non-antigenic stimulus (ISO)

apoptotic process (IEA)

axonal fasciculation (ISO)

cellular response to staurosporine (IEA)

epithelial cell differentiation (IEA)

execution phase of apoptosis (IEA)

hepatocyte apoptotic process (IEA)

intrinsic apoptotic signaling pathway by p53 class mediator (IEA)

lens development in camera-type eye (ISO)

positive regulation of apoptotic process (IEA,ISO)

positive regulation of necroptotic process (IEA)

positive regulation of neuron apoptotic process (IBA,IEA,ISO)

positive regulation of retinal cell programmed cell death (ISO)

protein autoprocessing (IEA)

proteolysis (IEA)

pyroptosis (IEA)

regulation of inflammatory response (IEA)

regulation of programmed cell death (IEA)

response to cytokine (ISO)

response to estradiol (ISO)

response to gamma radiation (ISO)

response to glucose (ISO)

response to hydrogen peroxide (ISO)

response to iron ion (ISO)

response to metal ion (ISO)

response to organic substance (ISO)

response to organonitrogen compound (ISO)

response to testosterone (ISO)

Cellular Component

AIM2 inflammasome complex (IEA)

axon (ISO)

cytoplasm (IBA,IEA)

cytosol (IEA)

IPAF inflammasome complex (IEA)

neuronal cell body (ISO)

NLRP3 inflammasome complex (IEA)

nucleoplasm (IEA)

nucleus (IEA)

Molecular Function

cysteine-type endopeptidase activity (IEA)

cysteine-type endopeptidase activity involved in apoptotic process (IEA)

cysteine-type endopeptidase activity involved in execution phase of apoptosis (IBA,IEA)

cysteine-type peptidase activity (IEA)

endopeptidase activity (IEA,ISO)

hydrolase activity (IEA)

identical protein binding (IEA)

peptidase activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CASP6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	112,520,629 - 112,537,045 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	112,519,450 - 112,534,315 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	120,664,346 - 120,678,399 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CASP6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	109,664,388 - 109,709,767 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	109,688,622 - 109,703,583 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	110,609,784 - 110,624,601 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	110,829,234 - 110,844,078 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	110,967,388 - 110,982,233	NCBI
Celera	4	107,903,448 - 107,918,292 (-)	NCBI		Celera
Cytogenetic Map	4	q25	NCBI
HuRef	4	106,342,777 - 106,357,627 (-)	NCBI		HuRef
CHM1_1	4	110,586,394 - 110,601,238 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	112,966,324 - 113,010,471 (-)	NCBI		T2T-CHM13v2.0

Casp6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	129,695,064 - 129,707,761 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	129,695,074 - 129,707,752 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	129,901,415 - 129,914,112 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	129,901,425 - 129,914,103 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	129,604,343 - 129,617,020 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	129,893,486 - 129,905,973 (+)	NCBI		MGSCv36	mm8
Celera	3	136,415,853 - 136,428,433 (+)	NCBI		Celera
Cytogenetic Map	3	G3	NCBI
cM Map	3	59.5	NCBI

Casp6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	221,140,287 - 221,152,727 (+)	NCBI		GRCr8
mRatBN7.2	2	218,466,063 - 218,478,503 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	218,466,076 - 218,478,502 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	226,144,507 - 226,156,834 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	224,044,202 - 224,056,533 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	218,901,851 - 218,914,178 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	235,341,326 - 235,353,715 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	235,341,365 - 235,353,967 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	2	230,186,198 - 230,198,555 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	249,539,649 - 249,552,032 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	227,361,538 - 227,373,844 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	227,348,217 - 227,360,523 (+)	NCBI
Celera	2	210,748,422 - 210,760,763 (+)	NCBI		Celera
Cytogenetic Map	2	q43	NCBI

Casp6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955496	577,832 - 584,287 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955496	575,839 - 584,287 (+)	NCBI	ChiLan1.0	ChiLan1.0

CASP6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	107,781,319 - 107,798,789 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	108,075,317 - 108,092,294 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	102,186,215 - 102,201,992 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	112,753,988 - 112,768,836 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	112,753,988 - 112,768,836 (-)	Ensembl	panpan1.1		panPan2

CASP6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	29,897,706 - 29,910,522 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	29,897,823 - 29,911,469 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	12,119,155 - 12,132,295 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	30,117,004 - 30,130,146 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	30,117,008 - 30,130,778 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	30,111,494 - 30,124,567 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	29,855,989 - 29,869,067 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	9,980,365 - 9,993,491 (+)	NCBI		UU_Cfam_GSD_1.0

Casp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	11,030,886 - 11,038,493 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936563	911,304 - 919,119 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936563	912,502 - 920,025 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CASP6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	57,592,632 - 57,616,094 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	57,593,342 - 57,607,489 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	36,243,873 - 36,268,826 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Casp6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624830	171,427 - 184,814 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624830	170,392 - 179,883 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in CASP6
731 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium	8	2		4				3	1
Low	2	2	3	1	2	23	2		2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005656547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013989349	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000067	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK237197	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK392826	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU694741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBZA01000095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01086245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000010007 ⟹ ENSSSCP00000009745

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	8	112,483,392 - 112,529,597 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000010008 ⟹ ENSSSCP00000009746

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	8	112,520,629 - 112,534,314 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000047809 ⟹ ENSSSCP00000052662

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	8	112,520,861 - 112,534,314 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000073594 ⟹ ENSSSCP00000068855

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	8	112,520,629 - 112,537,045 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000097858 ⟹ ENSSSCP00000080049

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	8	112,529,352 - 112,534,314 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000099257 ⟹ ENSSSCP00000077592

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	8	112,520,629 - 112,529,597 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000105773 ⟹ ENSSSCP00000077536

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	8	112,520,629 - 112,534,314 (+)	Ensembl

RefSeq Acc Id:

XM_005656547 ⟹ XP_005656604

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	8	112,520,164 - 112,534,315 (+)	NCBI

Sequence:

show sequence

CACCCAGGGCAAATGGAAGTTCCCTTGCCAGGGATCCAATCCGAGCTGCAGCTGCAGGCCCAGC
CCTTTCAGAGACAACTTGGGATTCTTAACAGCGGGAACTCCCTTAAGCAAGACTTTTCAGCCAC
AAGTATATGCAGGAAGCTATCCAGTTAGATTTTTATTTTTCTCTCCCAATCCGCTCTACAAACA
AAGAGCATTTTAAAGTACTGTAAATCCTTGCAAGTCCTATAACGTAACTCGCACTGGGGAAAAG
ATTCCACGGGAAACAGGAAAACACAACACCCTGTACCTGAGGGCGTGGAGAAGAGCTAACACTT
GGGGCGGAGCTTGAGCGAGCCTTGCTGCCTGCAGGTGCTCTGAAACTGCCTGGGGCCTCCCACC
CGGGGTCCTCCCACCCCGGGACCGCCCCTTGGCCTCGGGATAAGAATTGCGGCGTCCCTTAGGC
TGGGTTCTGCTCTCCAGGCGCCAGGCTAAGAAGACCGCGTCCCCTGCCCTGCTTGGACGCTCTG
GCCCCCGCGAACTCCAGGTGAACGAAACGGACCTTAACTCAGCAGGGGGCACGGCCACCACCAA
CTCCCACCCCCACGCTCGGAGCGGGCGGCGGAGGGGGCCGAGGAGGAAGAGGCGGGGGCTGCGG
CTCCGGCTGCAGGAAGCAGAAGCCGGTCGCGGCGTCGGTGCTGCGCGTTCCGCTGCGATGAGCT
CGGCGCTGGACCTCCGCGGGGCAGGTGAAGAACAAAACATGACGGAAACAGATGCCTTCCCTAA
GAGAGAAGTGTTTGATCCAGCAGAAAAATACAAAATGGACCACAAGAGGAGAGGAGTTGCTTTA
ATCTTCAATCACGAGAGGTTCTTCTGGCACTTAACCCTGCCAGAAAGGCGAGGCACCAGTGCCG
ACAGAGACAACCTTAAGCGCAGGTTTTCAGATCTAGGATTTGAAGTGAAATGCTTTAATGATCT
TAGAGCTGAAGAATTACTGCTCAAAATTCATGAGGCATCAACTGCTAGCCATGTAGATGCCGAC
TGCTTTTTGTGTGTTTTCCTGAGTCACGGCGAAGGCAATCACATCTACGCATATGATGCCAAAA
TTGAAATTCAGACACTGACTGGCTTGTTCAAAGGAGACAAGTGTCAGAGCCTGGTTGGAAAACC
CAAGATATTTATCATTCAGGCGTGTCGGGGAAACCAGCATGATGTGCCAGTCCTGCCTTTGGAT
GTCGTGGATCATCAGACAGACAAGCTGGATGCCAACCTAACCCAGGTGGACGCCGCCTCGGTGT
ACACCCTGCCTGCAGGCGCAGACTTCCTCATGTGTTACTCGGTGGCAGAAGGTTATTATTCTCA
TCGGGAAACTGTGAACGGCTCCTGGTACATTCAGGATTTGTGCGAGATGCTGGGAAAATTCGGC
TCCTCCTTAGAGTTCACAGAACTCCTCACACTGGTGAACAGGAAAGTGTCTCAGCGCCGAGTAG
ACTTCTGCAAAGACCCAGATGCAATTGGAAAGAAGCAGGTTCCTTGCTTTGCCTCAATGCTAAC
TAAAAAGCTGCATTTCTTTCCAAAATCCTAATAAGGCATCCTGGTTTATGTGTCATTCAAAATC
GGTTTTCTCTTTTTACATAAAGTAGTACCACTAGGCTGAAGAATTATGGTGTAGGAATTTAAAA
CATTTTAAGCTTTAATGAGAATTTTTTAAAAAGTTCATATTGGACATGGTGAAGGGGTTTAATA
GACATAGAAAAGAAATCCTCAGGGAGTGCCTATAAATAGAAATTTACAAGCATTTGTAATTGCC
TTTTGTAGTAAATTTCAGGGTTACTCAAAATATCTTATTTAACTTGTATTTTGTGACTTTTTTA
TAAAACTGTTAAGGGTTTTTAAAACCTTAAAAATTACTTGTTTTCCCTTAATATTTGAAATTCA
TGTTTTATTAAATTTTTCTAATTCA

hide sequence

RefSeq Acc Id:

XM_013989349 ⟹ XP_013844803

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	8	112,519,450 - 112,534,315 (+)	NCBI

Sequence:

show sequence

ATTCCTTAGCTATTGCTTTAAAAGGCTAAAATTAAACATTTATAATTGTGAAATAAGTATCCTA
ATGCTTTGTATTTGTACGTCTTAAGGTAGACAGTATCTTACTTTAAAATACATAACCGTATATG
TATAAAAGCAATACAGTATTGTGAGATACTTGAGAAAAAATAAATTTCTTTCGTCTCCTTTCAG
ATAAATGGAGGGTCAGCCAATTGAAATTCCACTTCTATATAAGGACTATTTCTGTATAGAGGAG
ATACCCTGAAAACTAGGCAGAAGGACAGGAAGCTCTGGTGGTCAGAGAAGTCATTCAAACTGGA
TAGAGTCCAGAGTGCAGTTGCAGAAACCTGAATCTTATTCAGGTTAAATATTTGTTGAGCTCCT
CCTACCTTCTAAGCAACTGCTGGGTAATGGGGAAACCGAAAGAAGTCAATTCTGTTTTCAATAA
GCTTAAGATGGTGGCAATAGAAATTCGTTGAGCTCTTCACAAGCCAGGCATTGTTCTGACTACA
GTAGTTTAACTCAATTGTCAAAACCGTATGAGGGAGATAATTGATATTCCATGTCTTCACTGCA
GCATGTTACTAAGATAGTGATTTCTGAAATATTTTATGCATATAATGAAATGAACAGCAAATGG
CAAAGGGTGAGTAAAATCCTTTGATTTCATACTCTATTCAATGACCAAGTAAGACTTTTTTTTT
TTTTTTTGCGCACCCAGGGCAAATGGAAGTTCCCTTGCCAGGGATCCAATCCGAGCTGCAGCTG
CAGGCCCAGCCCTTTCAGAGACAACTTGGGATTCTTAACAGCGGGAACTCCCTTAAGCAAGACT
TTTCAGCCACAAGTATATGCAGGAAGCTATCCAGTTAGATTTTTATTTTTCTCTCCCAATCCGC
TCTACAAACAAAGAGCATTTTAAAGTACTGTAAATCCTTGCAAGTCCTATAACGTAACTCGCAC
TGGGGAAAAGATTCCACGGGAAACAGGAAAACACAACACCCTGTACCTGAGGGCGTGGAGAAGA
GCTAACACTTGGGGCGGAGCTTGAGCGAGCCTTGCTGCCTGCAGGTGCTCTGAAACTGCCTGGG
GCCTCCCACCCGGGGTCCTCCCACCCCGGGACCGCCCCTTGGCCTCGGGATAAGAATTGCGGCG
TCCCTTAGGCTGGGTTCTGCTCTCCAGGCGCCAGGCTAAGAAGACCGCGTCCCCTGCCCTGCTT
GGACGCTCTGGCCCCCGCGAACTCCAGGTGAACGAAACGGACCTTAACTCAGCAGGGGGCACGG
CCACCACCAACTCCCACCCCCACGCTCGGAGCGGGCGGCGGAGGGGGCCGAGGAGGAAGAGGCG
GGGGCTGCGGCTCCGGCTGCAGGAAGCAGAAGCCGGTCGCGGCGTCGGTGCTGCGCGTTCCGCT
GCGATGAGCTCGGCGCTGGACCTCCGCGGGGCAGGTGAAGAACAAAACATGACGGAAACAGATG
CCTTCCCTAAGAGGTTTTCAGATCTAGGATTTGAAGTGAAATGCTTTAATGATCTTAGAGCTGA
AGAATTACTGCTCAAAATTCATGAGGCATCAACTGCTAGCCATGTAGATGCCGACTGCTTTTTG
TGTGTTTTCCTGAGTCACGGCGAAGGCAATCACATCTACGCATATGATGCCAAAATTGAAATTC
AGACACTGACTGGCTTGTTCAAAGGAGACAAGTGTCAGAGCCTGGTTGGAAAACCCAAGATATT
TATCATTCAGGCGTGTCGGGGAAACCAGCATGATGTGCCAGTCCTGCCTTTGGATGTCGTGGAT
CATCAGACAGACAAGCTGGATGCCAACCTAACCCAGGTGGACGCCGCCTCGGTGTACACCCTGC
CTGCAGGCGCAGACTTCCTCATGTGTTACTCGGTGGCAGAAGGTTATTATTCTCATCGGGAAAC
TGTGAACGGCTCCTGGTACATTCAGGATTTGTGCGAGATGCTGGGAAAATTCGGCTCCTCCTTA
GAGTTCACAGAACTCCTCACACTGGTGAACAGGAAAGTGTCTCAGCGCCGAGTAGACTTCTGCA
AAGACCCAGATGCAATTGGAAAGAAGCAGGTTCCTTGCTTTGCCTCAATGCTAACTAAAAAGCT
GCATTTCTTTCCAAAATCCTAATAAGGCATCCTGGTTTATGTGTCATTCAAAATCGGTTTTCTC
TTTTTACATAAAGTAGTACCACTAGGCTGAAGAATTATGGTGTAGGAATTTAAAACATTTTAAG
CTTTAATGAGAATTTTTTAAAAAGTTCATATTGGACATGGTGAAGGGGTTTAATAGACATAGAA
AAGAAATCCTCAGGGAGTGCCTATAAATAGAAATTTACAAGCATTTGTAATTGCCTTTTGTAGT
AAATTTCAGGGTTACTCAAAATATCTTATTTAACTTGTATTTTGTGACTTTTTTATAAAACTGT
TAAGGGTTTTTAAAACCTTAAAAATTACTTGTTTTCCCTTAATATTTGAAATTCATGTTTTATT
AAATTTTTCTAATTCA

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Protein Sequences


Protein RefSeqs	XP_005656604	(Get FASTA)	NCBI Sequence Viewer
	XP_013844803	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000009746
	ENSSSCP00000009746.4
	ENSSSCP00000052662.2
	ENSSSCP00000068855.1
	ENSSSCP00000077536
	ENSSSCP00000077536.1
	ENSSSCP00000077592.1
	ENSSSCP00000080049.1
	ENSSSCP00005036298.1
	ENSSSCP00005036300.1
	ENSSSCP00005036323.1
	ENSSSCP00005036373.1
	ENSSSCP00015015517.1
	ENSSSCP00015015581.1
	ENSSSCP00025003852.1
	ENSSSCP00025003855.1
	ENSSSCP00025003857.1
	ENSSSCP00035044442.1
	ENSSSCP00035044452.1
	ENSSSCP00035044474.1
	ENSSSCP00040040993.1
	ENSSSCP00040041064.1
	ENSSSCP00045033534.1
	ENSSSCP00045033596.1
	ENSSSCP00045033674.1
	ENSSSCP00055013194.1
	ENSSSCP00055013244.1
	ENSSSCP00055013324.1
	ENSSSCP00060044765.1
	ENSSSCP00060044783.1
	ENSSSCP00065006383.1
	ENSSSCP00065006390.1
	ENSSSCP00065006391.1
	ENSSSCP00065006404.1
	ENSSSCP00070033605.1
	ENSSSCP00070033608.1
	ENSSSCP00070033614.1
	ENSSSCP00070033616.1
GenBank Protein	JAG69673	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_013844803 ⟸ XM_013989349
- Peptide Label:	isoform X2
- UniProtKB:	A0A8D0K1M4 (UniProtKB/TrEMBL), F1S131 (UniProtKB/TrEMBL), A0A4X1UW10 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSSALDLRGAGEEQNMTETDAFPKRFSDLGFEVKCFNDLRAEELLLKIHEASTASHVDADCFLC VFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCQSLVGKPKIFIIQACRGNQHDVPVLPLDVVDH QTDKLDANLTQVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKFGSSLE FTELLTLVNRKVSQRRVDFCKDPDAIGKKQVPCFASMLTKKLHFFPKS hide sequence

RefSeq Acc Id:	XP_005656604 ⟸ XM_005656547
- Peptide Label:	isoform X1
- UniProtKB:	A0A4X1UXQ4 (UniProtKB/TrEMBL), A0A0B8S0B0 (UniProtKB/TrEMBL), A0A8W4FDP3 (UniProtKB/TrEMBL), A0A8D1XN22 (UniProtKB/TrEMBL), A0A8D0QWP5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSSALDLRGAGEEQNMTETDAFPKREVFDPAEKYKMDHKRRGVALIFNHERFFWHLTLPERRGT SADRDNLKRRFSDLGFEVKCFNDLRAEELLLKIHEASTASHVDADCFLCVFLSHGEGNHIYAYD AKIEIQTLTGLFKGDKCQSLVGKPKIFIIQACRGNQHDVPVLPLDVVDHQTDKLDANLTQVDAA SVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKFGSSLEFTELLTLVNRKVSQR RVDFCKDPDAIGKKQVPCFASMLTKKLHFFPKS hide sequence

RefSeq Acc Id:

ENSSSCP00000068855 ⟸ ENSSSCT00000073594

RefSeq Acc Id:

ENSSSCP00000009745 ⟸ ENSSSCT00000010007

RefSeq Acc Id:

ENSSSCP00000009746 ⟸ ENSSSCT00000010008

RefSeq Acc Id:

ENSSSCP00000052662 ⟸ ENSSSCT00000047809

RefSeq Acc Id:

ENSSSCP00000077536 ⟸ ENSSSCT00000105773

RefSeq Acc Id:

ENSSSCP00000080049 ⟸ ENSSSCT00000097858

RefSeq Acc Id:

ENSSSCP00000077592 ⟸ ENSSSCT00000099257

Protein Domains

Caspase family p10 Caspase family p20

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000009140	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00005036682	UniProtKB/TrEMBL
	ENSSSCG00015029118	UniProtKB/TrEMBL
	ENSSSCG00025007262	UniProtKB/TrEMBL
	ENSSSCG00035076233	UniProtKB/TrEMBL
	ENSSSCG00040067651	UniProtKB/TrEMBL
	ENSSSCG00045028068	UniProtKB/TrEMBL
	ENSSSCG00055008418	UniProtKB/TrEMBL
	ENSSSCG00060074875	UniProtKB/TrEMBL
	ENSSSCG00065011769	UniProtKB/TrEMBL
	ENSSSCG00070020201	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000010008	ENTREZGENE
	ENSSSCT00000010008.5	UniProtKB/TrEMBL
	ENSSSCT00000047809.3	UniProtKB/TrEMBL
	ENSSSCT00000073594.2	UniProtKB/TrEMBL
	ENSSSCT00000097858.1	UniProtKB/TrEMBL
	ENSSSCT00000099257.1	UniProtKB/TrEMBL
	ENSSSCT00000105773	ENTREZGENE
	ENSSSCT00000105773.1	UniProtKB/TrEMBL
	ENSSSCT00005058757.1	UniProtKB/TrEMBL
	ENSSSCT00005058763.1	UniProtKB/TrEMBL
	ENSSSCT00005058805.1	UniProtKB/TrEMBL
	ENSSSCT00005058909.1	UniProtKB/TrEMBL
	ENSSSCT00015039012.1	UniProtKB/TrEMBL
	ENSSSCT00015039197.1	UniProtKB/TrEMBL
	ENSSSCT00025009676.1	UniProtKB/TrEMBL
	ENSSSCT00025009685.1	UniProtKB/TrEMBL
	ENSSSCT00025009690.1	UniProtKB/TrEMBL
	ENSSSCT00035103819.1	UniProtKB/TrEMBL
	ENSSSCT00035103844.1	UniProtKB/TrEMBL
	ENSSSCT00035103883.1	UniProtKB/TrEMBL
	ENSSSCT00040092825.1	UniProtKB/TrEMBL
	ENSSSCT00040092943.1	UniProtKB/TrEMBL
	ENSSSCT00045048237.1	UniProtKB/TrEMBL
	ENSSSCT00045048328.1	UniProtKB/TrEMBL
	ENSSSCT00045048436.1	UniProtKB/TrEMBL
	ENSSSCT00055016723.1	UniProtKB/TrEMBL
	ENSSSCT00055016785.1	UniProtKB/TrEMBL
	ENSSSCT00055016880.1	UniProtKB/TrEMBL
	ENSSSCT00060102662.1	UniProtKB/TrEMBL
	ENSSSCT00060102711.1	UniProtKB/TrEMBL
	ENSSSCT00065015653.1	UniProtKB/TrEMBL
	ENSSSCT00065015669.1	UniProtKB/TrEMBL
	ENSSSCT00065015671.1	UniProtKB/TrEMBL
	ENSSSCT00065015702.1	UniProtKB/TrEMBL
	ENSSSCT00070040104.1	UniProtKB/TrEMBL
	ENSSSCT00070040107.1	UniProtKB/TrEMBL
	ENSSSCT00070040113.1	UniProtKB/TrEMBL
	ENSSSCT00070040115.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1460	UniProtKB/TrEMBL
InterPro	Caspase-like_dom_sf	UniProtKB/TrEMBL
	Caspase_cys_AS	UniProtKB/TrEMBL
	Caspase_his_AS	UniProtKB/TrEMBL
	Pept_C14_caspase	UniProtKB/TrEMBL
	Pept_C14_p10	UniProtKB/TrEMBL
	Pept_C14_p20	UniProtKB/TrEMBL
	Pept_C14A	UniProtKB/TrEMBL
KEGG Report	ssc:100517293	UniProtKB/TrEMBL
NCBI Gene	CASP6	ENTREZGENE
PANTHER	CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18	UniProtKB/TrEMBL
	CASPASE-12	UniProtKB/TrEMBL
	CASPASE-3	UniProtKB/TrEMBL
	PTHR10454	UniProtKB/TrEMBL
	PTHR10454:SF206	UniProtKB/TrEMBL
Pfam	Peptidase_C14	UniProtKB/TrEMBL
PRINTS	IL1BCENZYME	UniProtKB/TrEMBL
PROSITE	CASPASE_CYS	UniProtKB/TrEMBL
	CASPASE_HIS	UniProtKB/TrEMBL
	CASPASE_P10	UniProtKB/TrEMBL
	CASPASE_P20	UniProtKB/TrEMBL
SMART	CASc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52129	UniProtKB/TrEMBL
UniProt	A0A0B8S0B0	ENTREZGENE
	A0A287B811_PIG	UniProtKB/TrEMBL
	A0A4X1UU59_PIG	UniProtKB/TrEMBL
	A0A4X1UW10	ENTREZGENE, UniProtKB/TrEMBL
	A0A4X1UXQ4	ENTREZGENE, UniProtKB/TrEMBL
	A0A5G2QXI3_PIG	UniProtKB/TrEMBL
	A0A8D0JZD6_PIG	UniProtKB/TrEMBL
	A0A8D0K1M4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D0N9Y5_PIG	UniProtKB/TrEMBL
	A0A8D0QWP5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1XN22	ENTREZGENE, UniProtKB/TrEMBL
	A0A8W4FDP3	ENTREZGENE
	A0A8W4FL33_PIG	UniProtKB/TrEMBL
	F1S131	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	A0A8W4FDP3	UniProtKB/TrEMBL
	A0A8W4FEA9	UniProtKB/TrEMBL
VGNC ID	VGNC:86202	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar