CASP6 (caspase 6) - Rat Genome Database

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Gene: CASP6 (caspase 6) Pan paniscus
Analyze
Symbol: CASP6
Name: caspase 6
RGD ID: 11959937
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); INVOLVED IN acute inflammatory response to non-antigenic stimulus (ortholog); axonal fasciculation (ortholog); lens development in camera-type eye (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); brain ischemia (ortholog); Breast Neoplasms (ortholog); FOUND IN axon (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: caspase-6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23107,781,319 - 107,798,789 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14108,075,317 - 108,092,294 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04102,186,215 - 102,201,992 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14112,753,988 - 112,768,836 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4112,753,988 - 112,768,836 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (ISO)
cytoplasm  (IEA)
cytosol  (IEA)
neuronal cell body  (ISO)
nucleoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
CASP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23107,781,319 - 107,798,789 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14108,075,317 - 108,092,294 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04102,186,215 - 102,201,992 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14112,753,988 - 112,768,836 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4112,753,988 - 112,768,836 (-)Ensemblpanpan1.1panPan2
CASP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384109,664,388 - 109,709,767 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4109,688,622 - 109,703,583 (-)EnsemblGRCh38hg38GRCh38
GRCh374110,609,784 - 110,624,601 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364110,829,234 - 110,844,078 (-)NCBINCBI36Build 36hg18NCBI36
Build 344110,967,388 - 110,982,233NCBI
Celera4107,903,448 - 107,918,292 (-)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4106,342,777 - 106,357,627 (-)NCBIHuRef
CHM1_14110,586,394 - 110,601,238 (-)NCBICHM1_1
T2T-CHM13v2.04112,966,324 - 113,010,471 (-)NCBIT2T-CHM13v2.0
Casp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393129,695,064 - 129,707,761 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3129,695,074 - 129,707,752 (+)EnsemblGRCm39 Ensembl
GRCm383129,901,415 - 129,914,112 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,901,425 - 129,914,103 (+)EnsemblGRCm38mm10GRCm38
MGSCv373129,604,343 - 129,617,020 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363129,893,486 - 129,905,973 (+)NCBIMGSCv36mm8
Celera3136,415,853 - 136,428,433 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map359.5NCBI
Casp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82221,140,287 - 221,152,727 (+)NCBIGRCr8
mRatBN7.22218,466,063 - 218,478,503 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2218,466,076 - 218,478,502 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2226,144,507 - 226,156,834 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02224,044,202 - 224,056,533 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02218,901,851 - 218,914,178 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02235,341,326 - 235,353,715 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2235,341,365 - 235,353,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl2230,186,198 - 230,198,555 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02249,539,649 - 249,552,032 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42227,361,538 - 227,373,844 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12227,348,217 - 227,360,523 (+)NCBI
Celera2210,748,422 - 210,760,763 (+)NCBICelera
Cytogenetic Map2q43NCBI
Casp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955496577,832 - 584,287 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955496575,839 - 584,287 (+)NCBIChiLan1.0ChiLan1.0
CASP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13229,897,706 - 29,910,522 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3229,897,823 - 29,911,469 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3212,119,155 - 12,132,295 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03230,117,004 - 30,130,146 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3230,117,008 - 30,130,778 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13230,111,494 - 30,124,567 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03229,855,989 - 29,869,067 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,980,365 - 9,993,491 (+)NCBIUU_Cfam_GSD_1.0
Casp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530111,030,886 - 11,038,493 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936563911,304 - 919,119 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936563912,502 - 920,025 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8112,520,629 - 112,537,045 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18112,519,450 - 112,534,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28120,664,346 - 120,678,399 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CASP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1757,592,632 - 57,616,094 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl757,593,342 - 57,607,489 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603736,243,873 - 36,268,826 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Casp6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624830171,427 - 184,814 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624830170,392 - 179,883 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000050625   ⟹   ENSPPAP00000027782
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4112,753,988 - 112,768,836 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000050629   ⟹   ENSPPAP00000027786
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4112,753,988 - 112,768,726 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000050633   ⟹   ENSPPAP00000027790
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4112,759,941 - 112,768,653 (-)Ensembl
RefSeq Acc Id: XM_003830015   ⟹   XP_003830063
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23107,781,319 - 107,798,789 (-)NCBI
NHGRI_mPanPan14108,075,317 - 108,092,294 (-)NCBI
Mhudiblu_PPA_v04102,186,215 - 102,201,990 (-)NCBI
PanPan1.14112,753,988 - 112,768,836 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008955379   ⟹   XP_008953627
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23107,781,319 - 107,796,046 (-)NCBI
NHGRI_mPanPan14108,075,317 - 108,089,551 (-)NCBI
Mhudiblu_PPA_v04102,186,739 - 102,200,951 (-)NCBI
PanPan1.14112,753,988 - 112,768,564 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008955380   ⟹   XP_008953628
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23107,781,319 - 107,798,787 (-)NCBI
NHGRI_mPanPan14108,075,317 - 108,092,292 (-)NCBI
Mhudiblu_PPA_v04102,186,215 - 102,201,992 (-)NCBI
PanPan1.14112,753,988 - 112,768,726 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034958999   ⟹   XP_034814890
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23107,781,319 - 107,795,393 (-)NCBI
NHGRI_mPanPan14108,075,317 - 108,088,903 (-)NCBI
Mhudiblu_PPA_v04102,186,739 - 102,198,689 (-)NCBI
RefSeq Acc Id: XP_003830063   ⟸   XM_003830015
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BHM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008953628   ⟸   XM_008955380
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BMA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008953627   ⟸   XM_008955379
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_034814890   ⟸   XM_034958999
- Peptide Label: isoform X2
Ensembl Acc Id: ENSPPAP00000027790   ⟸   ENSPPAT00000050633
Ensembl Acc Id: ENSPPAP00000027786   ⟸   ENSPPAT00000050629
Ensembl Acc Id: ENSPPAP00000027782   ⟸   ENSPPAT00000050625
Protein Domains
Caspase family p10   Caspase family p20


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036967 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000050625.1 UniProtKB/TrEMBL
  ENSPPAT00000050629.1 UniProtKB/TrEMBL
  ENSPPAT00000050633.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1460 UniProtKB/TrEMBL
InterPro Caspase-like_dom_sf UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/TrEMBL
  Caspase_his_AS UniProtKB/TrEMBL
  Pept_C14_caspase UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/TrEMBL
  Pept_C14_p20 UniProtKB/TrEMBL
  Pept_C14A UniProtKB/TrEMBL
KEGG Report pps:100973393 UniProtKB/TrEMBL
NCBI Gene CASP6 ENTREZGENE
PANTHER PTHR10454 UniProtKB/TrEMBL
  PTHR10454:SF206 UniProtKB/TrEMBL
Pfam Peptidase_C14 UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/TrEMBL
PROSITE CASPASE_CYS UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/TrEMBL
SMART CASc UniProtKB/TrEMBL
Superfamily-SCOP SSF52129 UniProtKB/TrEMBL
UniProt A0A2R9BDU9_PANPA UniProtKB/TrEMBL
  A0A2R9BHM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BMA1 ENTREZGENE, UniProtKB/TrEMBL