RGD Reference Report - Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis. - Rat Genome Database

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Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis.

Authors: Allen, JW  Eldadah, BA  Huang, X  Knoblach, SM  Faden, AI 
Citation: Allen JW, etal., J Neurosci Res. 2001 Jul 1;65(1):45-53.
RGD ID: 2301329
Pubmed: PMID:11433428   (View Abstract at PubMed)
DOI: DOI:10.1002/jnr.1126   (Journal Full-text)

beta-amyloid peptide (Abeta) has been implicated in the pathogenesis of Alzheimer disease and has been reported to induce apoptotic death in cell culture. Cysteine proteases, a family of enzymes known as caspases, mediate cell death in many models of apoptosis. Multiple caspases have been implicated in Abeta toxicity; these reports are conflicting. We show that treatment of cerebellar granule cells (CGC) with Abeta25-35 causes apoptosis associated with increased activity of caspases-2, -3 and -6. Selective inhibition of each of these three caspases provides significant protection against Abeta-mediated apoptosis. In contrast, no change in caspase-1 activity was seen after Abeta25-35 application, nor was inhibition of caspase-1 neuroprotective. Similar to CGC, cortical neuronal cultures treated with Abeta25-35 demonstrate increased caspase-3 activity but not caspase-1 activity. Furthermore, significant neuroprotection is elicited by selective inhibition of caspase-3 in cortical neurons administered Abeta25-35, whereas selective caspase-1 inhibition has no effect. Taken together, these findings indicate that multiple executioner caspases may be involved in neuronal apoptosis induced by Abeta.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of neuron apoptotic process  IMP 2301329 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Casp6  (caspase 6)


Additional Information