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Gene: CASP6 (caspase 6) Homo sapiens
Symbol: CASP6
Name: caspase 6
Description: Exhibits cysteine-type endopeptidase activity involved in execution phase of apoptosis and identical protein binding activity. Involved in cellular response to staurosporine; epithelial cell differentiation; and proteolysis. Localizes to the cytosol and nucleoplasm. Implicated in ovarian carcinoma. Biomarker of Alzheimer's disease; ductal carcinoma in situ; lung non-small cell carcinoma; and prostatic hypertrophy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apoptotic protease MCH-2; CASP-6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; caspase-6; MCH2
Mus musculus (house mouse) : Casp6 (caspase 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Casp6 (caspase 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Casp6 (caspase 6)
Pan paniscus (bonobo/pygmy chimpanzee) : CASP6 (caspase 6)
Canis lupus familiaris (dog) : CASP6 (caspase 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Casp6 (caspase 6)
Sus scrofa (pig) : CASP6 (caspase 6)
Chlorocebus sabaeus (green monkey) : CASP6 (caspase 6)
Heterocephalus glaber (naked mole-rat) : Casp6 (caspase 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl4109,688,622 - 109,703,583 (-)Ensembl
GRCh384109,688,628 - 109,703,445 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374110,609,785 - 110,629,814 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364110,829,234 - 110,844,078 (-)NCBINCBI36hg18NCBI36
Build 344110,967,388 - 110,982,233NCBI
Celera4107,903,448 - 107,918,292 (-)NCBI
Cytogenetic Map4q25NCBI
HuRef4106,342,777 - 106,357,627 (-)NCBIHuRef
CHM1_14110,586,394 - 110,601,238 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CASP6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732006
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.