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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:78759
Term: N,N-dimethylsphingosine
Definition: A sphingoid that is sphingosine in which the two amino hydrogens are replaced by amino groups.
Chemical ID: MESH:C061800
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsISORGD:7310026480464CTD[Bortezomib co-treated with N, N-dimethylsphingosine] results in increased cleavage of and results in increased activity of CASP3 protein

PMID:21195056
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.