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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:8772
Term: raloxifene
Definition: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.
Chemical ID: MESH:D020849
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDRaloxifene Hydrochloride inhibits the reaction [Decitabine results in increased activity of CASP3 protein]PMID:23385821
Casp3decreases expressionISOCASP3 (Homo sapiens)6480464CTDRaloxifene Hydrochloride results in decreased expression of CASP3 mRNA; Raloxifene Hydrochloride results in decreased expression of CASP3 proteinPMID:27999800
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDRaloxifene Hydrochloride results in increased cleavage of CASP3 proteinPMID:22965848 PMID:28430601 PMID:28711499
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDRaloxifene Hydrochloride results in increased expression of CASP3 mRNA; Raloxifene Hydrochloride results in increased expression of CASP3 protein modified formPMID:20945400 PMID:29705353
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[Resveratrol co-treated with Raloxifene Hydrochloride] results in decreased expression of CASP3 mRNA; STAT3 protein affects the reaction [Raloxifene Hydrochloride results in increased cleavage of CASP3 protein]PMID:28430601 PMID:29705353
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