Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CASP3 protein]; [Caspase Inhibitors results in decreased activity of CASP8 protein] inhibits the reaction [Estradiol results in increased activity of CASP3 protein]; [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in decreased activity of CASP3 protein; [Methylnitrosourea co-treated with Estradiol] results in decreased expression of CASP3 mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of CASP3 mRNA; [Resveratrol co-treated with Estradiol] results in increased activity of CASP3 protein; ABCC8 protein promotes the reaction [Estradiol results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Estradiol results in increased activity of CASP3 protein]; Eicosapentaenoic Acid inhibits the reaction [Estradiol results in decreased expression of CASP3 protein]; Estradiol inhibits the reaction [Corticosterone results in increased cleavage of CASP3 protein]; Estradiol inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of CASP3 protein modified form]; Estradiol promotes the reaction [Testosterone inhibits the reaction [Corticosterone results in increased cleavage of CASP3 protein]]; Fulvestrant inhibits the reaction [Estradiol results in increased activity of CASP3 protein]; pimagedine inhibits the reaction [Estradiol results in increased activity of CASP3 protein]; Tamoxifen inhibits the reaction [Estradiol results in increased activity of CASP3 protein]; Testosterone promotes the reaction [Estradiol inhibits the reaction [Corticosterone results in increased cleavage of CASP3 protein]]
Estradiol analog results in increased expression of CASP3 mRNA; Estradiol analog results in increased expression of CASP3 protein; Estradiol results in increased expression of CASP3 protein modified form
[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[Estradiol co-treated with LEP protein] results in decreased activity of CASP3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[LEP protein co-treated with Estradiol] results in decreased expression of CASP3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Estradiol results in decreased activity of CASP3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Estradiol results in decreased expression of CASP3 protein]; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with Estradiol] results in decreased activity of CASP3 protein]; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with Estradiol] results in decreased expression of CASP3 protein]; [ESR1 protein results in increased susceptibility to Estradiol] inhibits the reaction [Fenofibrate results in decreased expression of CASP3 protein]; [ESR2 protein results in increased susceptibility to Estradiol] which results in increased cleavage of CASP3 protein; [Estradiol co-treated with LEP protein] results in decreased expression of CASP3 mRNA; [Estradiol co-treated with LEP protein] results in decreased expression of CASP3 protein; allyl sulfide inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein]; ESR1 protein alternative form promotes the reaction [allyl sulfide inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein]]; ESR1 protein alternative form promotes the reaction [MK 2206 inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein]]; ESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein]]; Estradiol affects the reaction [dibenzo(a,l)pyrene results in increased cleavage of CASP3 protein]; Estradiol inhibits the reaction [amyloid beta-protein (1-42) results in increased cleavage of CASP3 protein]; Estradiol inhibits the reaction [APP protein results in increased activity of CASP3 protein]; Estradiol inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]; Estradiol inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]; Estradiol promotes the reaction [LEP protein results in decreased activity of CASP3 protein]; LEP protein promotes the reaction [Estradiol results in decreased activity of CASP3 protein]; MK 2206 inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein]; Okadaic Acid inhibits the reaction [Estradiol inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]]; ORAI1 protein promotes the reaction [Estradiol results in decreased expression of CASP3 mRNA]; RTKI cpd inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [[ESR2 protein results in increased susceptibility to Estradiol] which results in increased cleavage of CASP3 protein]; TXNIP protein inhibits the reaction [Estradiol inhibits the reaction [amyloid beta-protein (1-42) results in increased cleavage of CASP3 protein]]; TXNIP protein inhibits the reaction [Estradiol inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]]
